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Öğe Comparison of fluconazole and ketoconazole in the treatment of superficial dermatophyte infections(1996) Dogan G.; Sasmaz S.; Ozcan A.; Senol M.; Yologlu S.Background and design.- In this study, we compared the efficacy of fluconazole and ketoconazole in dermatophytosis. Fifty six patients with superficial dermatophyte infection, were randomly given either once-weekly of oral fluconazole 150 mg, or oral ketoconazole 200 mg/d for four weeks. The efficacy of the treatment was evaluated clinically cure and direct microscopic examination at 30th, 60th and 90th day after cessation of the drug. Side effect profile was decided with patients' complaints and laboratory examination. Results.- At the end of study, 85.71% on the 30th day, 92.86% on the 60th day and 85.71% on the 90th day in the fluconazole group showed mycologic eradication; in the ketoconazole group were found 89.28%, 85.71% and 82.14%, respectively. But there was no statistical difference between the two agents. None of the patients described any subjective side effects and all laboratory examination results were normal. Conclusion.- Finally, fluconazole and ketoconazole were found to be equally effective in superficial dermatophyte infections.Öğe Syringocystadenoma papilliferum(1997) Ozcan A.; Senol M.; Dogan G.; Aydin A.; Atik E.Syringocystadenoma papilliferum is a rare adnexal benign tumur which commonly develops from apocrine sweat glands. It is mostly seen in women. The majority of the lesions are located on the scalp and neck. They are rarely found on the trunk and the extremities. The lesion is generally found as an asymptomatic solitary plaque. A basal cell epithelioma can rarely arise in this lesion especially when exists with a nevus sebaceus. A 33-year-old woman with a syringocystadenoma papilliferum was presented and the current literature on this issue was reviewed.Öğe Three cases of verrucous carcinoma(Blackwell Publishing, 1998) Dogan G.; Oram Y.; Hazneci E.; Özen S.; Karincao?lu Y.; Çiralik H.Verrucous carcinoma of the skin and mucosa is an uncommon clinicopathological variant of low grade squamous cell carcinoma. Here, we present three different clinical types of verrucous carcinoma. The first patient presented with an anogenital verrucous carcinoma, also known as Buschke-Loewenstein tumour. The second patient had verrucous carcinoma of the heel with endophytic growth (i.e. epithelioma cuniculatum) and the third patient had gluteal verrucous carcinoma with a cauliflower-like appearance. Clinically, the lesion of the first patient best resembled giant condyloma accuminatum without any prominent verrucous component, whereas the second patient showed a big deep ulcer on the heel. None of the patients had metastasis. The diagnosis was confirmed with biopsy and total excision was performed in all cases. Although the cases have different clinical presentations in different locations, we think that they should be considered as a single entity; that is, verrucous carcinoma.Öğe The treatment of melasma with hydroquinone and hydroquinone, retinoic acid and corticosteroid combination(1995) Senol M.; Ozcan A.; Hazneci E.; Dogan G.Background and design. - For the purpose of comparing the efficacy of hydroquinone alone or a combination (with retinoic acid and corticosteroid) in the treatment of melasma, two groups of patients were studied. Results. - Hydroquinone and combination therapy were used for three months in each group (20 patients). There was no significant difference between the efficacy and the side effects of the two therapy schedule. Conclusion. - We concluded that hydroquinone alone is sufficient in the treatment of melasma because of its economic and practical properties.Öğe Two cases of acrokeratoelastoidosis: Failure of acitretin treatment(1996) Dogan G.; Oram Y.; Hazneci E.; Muezzinoglu B.; Aydin A.Acrokeratoelastoidosis (AKE) is a rare distinguished clinical entity among other papular acrokeratodermas. It is characterized by smooth shiny papules on the hands and feet. We present two unrelated cases of AKE with typical clinical and histologic findings. The clinical diagnosis was confirmed with histopathologic findings, particularly, fragmentation and rarefaction of elastic fibers in the dermis. In the treatment of AKE, 3 months of acitretin administration (0.5 mg/kg/d) was found ineffective. Its treatment is still unsatisfactory and needs further therapeutic trials.