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    Prevention of Fertility due to Chemotherapy-Induced Ovarian Failure: Role of Therapeutic Antioxidants
    (Springer Singapore, 2022) Melekoglu R.; Dogan U.K.; Celik N.Z.; Yilmaz E.
    Advancements in chemotherapy treatments are leading to increased survival rates for cancer sufferers. Advances in anticancer therapy have contributed to higher survival rates, but ovarian failure that leads to infertility is one of the long-term adverse effects due to primordial follicle loss caused by gonadotoxic chemotherapy. Therefore, prevention of premature ovarian failure and protection of the ovarian follicle pool has gained increasing attention to improve the quality of life of female cancer patients receiving chemotherapy. A non-invasive medical approach (including administration of antioxidant therapy to conventional chemotherapy regimens) to prevent chemotherapy-induced ovarian damage may be preferred, although there are successful invasive fertility preservation options. Most of the chemotherapeutic agents act by producing free radicals that cause cellular damage and necrosis of malignant cells as part of their mode of action in cancer treatment. Despite nearly three decades of research that sought to determine the effectiveness and safety of dietary antioxidant supplementation while undergoing conventional chemotherapy, some controversy remains about efficacy and safety. This claim has been backed up by numerous clinical trials which have demonstrated that certain antioxidants help to restore the body’s natural antioxidants, which are often depleted after chemotherapy treatment, and reduce side effects of cytotoxic agents, including prevention of chemotherapy-induced ovarian failure as well as increase in overall survival of patients receiving chemotherapy. Further randomized controlled clinical researches should be designed to evaluate the use of a specific combination of antioxidants in chemotherapy and determine optimal doses of antioxidants for specific cancer setting to prevent chemotherapy-induced ovarian failure. © Springer Nature Singapore Pte Ltd. 2022.