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Öğe Mortality predictors in earthquake victims admitted to intensive care unit in Kahramanmaraş earthquakes(Elsevier Ltd, 2024) Bicakcioglu M.; Gok A.; Cicek I.B.; Dogan Z.; Ozer A.B.Background: The purpose of this study is to report the data for patients followed-up in our intensive care unit due to the 6th February 2023, earthquake in Kahramanmaraş, Türkiye, and to investigate parameters affecting mortality. Methods: The demographic characteristics of patients followed-up in intensive care due to trauma following the earthquake, the treatments administered, developing complications, lengths of stay in the hospital and intensive care, and laboratory data were scanned retrospectively and recorded. These data were then compared between the surviving and non-surviving patients. Results: Twenty-six patients, 13 (50 %) male, were followed-up in our intensive care, 24 (92 %) due to being buried under earthquake debris, and 2 (8 %) due to falling from heights. Increased Sequential Organ Failure Assessment (SOFA) (p = 0.027), higher initial serum potassium (p = 0.043), higher initial serum phosphorus (p = 0.035), higher initial and peak serum magnesium (p = 0.004 and p = 0.001), lower initial and peak bicarbonate (p = 0.021 and p = 0.012) and higher initial and peak serum base deficit values (p = 0.012 and p = 0.009) were associated with mortality. In the subgroup with crush injuries, higher initial and peak serum potassium (p = 0.001 and p = 0.025), higher initial and peak serum magnesium (p = 0.005 and p = 0.004), lower initial and peak bicarbonate (p = 0.019 and p = 0.021) and higher initial and peak serum base deficit values (p = 0.017 and p = 0.025) were associated with mortality. Multiorgan dysfunction failure developed in nine patients, sepsis in seven, dissemine intravascular coagulation in four, and acute respiratory distress syndrome in two. Fasciotomy was performed on 2 (8 %) patients and amputation on 8 (31 %). Extremity injuries were most frequently observed. 10 (38.5 %) of the 12 (46 %) patients developing acute kidney injury required renal replacement therapy. 7 (27 %) patients died during follow-up. In logistic regression analysis, higher SOFA scores, lower initial bicarbonate and BE levels, higher serum initial potassium and magnesium levels were a risk factor for mortality. Higher SOFA scores, lower initial bicarbonate and base deficit and higher initial phosphorus values affected mortality in patients with crush syndrome. Conclusion: Not only increased SOFA, serum potassium, serum phosphorus, and serum magnesium, but also decreased bicarbonate, and base deficit were associated with mortality in earthquake victims with crush syndrome in ICU. © 2024Öğe Protective effect of quercetin against oxidative stress-induced toxicity associated with doxorubicin and cyclophosphamide in rat kidney and liver tissue(Iranian Society of Nephrology, 2017) Kocahan S.; Dogan Z.; Erdemli E.; Taskin E.Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy. Materials and Methods. Cyclophosphamide, 27 mg/kg, and doxorubicin, 1.8 mg/kg, were administered to rats as intraperitoneal doses once every 3 weeks for a total of 10 weeks with or without concurrent treatment with quercetin, 10 mg/kg/d. Oxidative stress parameters were evaluated in maternal kidney and liver tissues after gestation. Results. Doxorubicin was associated with elevated kidney tissue malondialdehyde relative to the controls and quercetin only treatment (P <.05). Both cyclophosphamide and doxorubicin were associated with elevated malondialdehyde levels in the liver tissue (P <.05). Doxorubicin treatment was associated with decreased liver glutathione peroxidase (P <.05). Quercetin treatment suppressed the accumulation of malondialdehyde and increased glutathione peroxidase levels during doxorubicin and cyclophosphamide treatment (P <.05) Conclusions. Treatment with quercetin in patients receiving doxorubicin and cyclophosphamide results in therapeutic restoration of homeostatic expression of the antioxidant parameters, reducing oxidative damage to the liver and kidney. © 2017, Iranian Society of Nephrology. All rights reserved.Öğe Quercetin protection against ciprofloxacin induced liver damage in rats(Taylor and Francis Ltd, 2016) Taslidere E.; Dogan Z.; Elbe H.; Vardi N.; Cetin A.; Turkoz Y.Ciprofloxacin is a common, broad spectrum antibacterial agent; however, evidence is accumulating that ciprofloxacin may cause liver damage. Quercetin is a free radical scavenger and antioxidant. We investigated histological changes in hepatic tissue of rats caused by ciprofloxacin and the effects of quercetin on these changes using histochemical and biochemical methods. We divided 28 adult female Wistar albino rats into four equal groups: control, quercetin treated, ciprofloxacin treated, and ciprofloxacin + quercetin treated. At the end of the experiment, liver samples were processed for light microscopic examination and biochemical measurements. Sections were prepared and stained with hematoxylin and eosin, and a histopathologic damage score was calculated. The sections from the control group appeared normal. Hemorrhage, inflammatory cell infiltration and intracellular vacuolization were observed in the ciprofloxacin group. The histopathological findings were reduced in the group treated with quercetin. Significant differences were found between the control and ciprofloxacin groups, and between the ciprofloxacin and ciprofloxacin + quercetin groups. Quercetin administration reduced liver injury caused by ciprofloxacin in rats. We suggest that quercetin may be useful for preventing ciprofloxacin induced liver damage. © 2015 The Biological Stain Commission.Öğe Volume comparison of caudal bupivacaine for inguinal hernia repair in children(2010) Dogan Z.; Yucel A.; Senoglu N.; Oksuz H.; Yildiz H.; Bakan V.; Ozkan K.U.Background: The efficacy of two different volumes of 0.25% bupivacaine for caudal blockade, in children undergoing inguinal hernia repair surgery regarding hernia pouch traction, was evaluated. Patients & Methods: Forty children aged between 1 to 5 years, undergoing elective inguinal herniorrhaphy or hydrocele repair were enrolled in the study. Patients received a caudal blockade either with bupivacaine 0.25% at 1.0 ml kg-1 (n=20), or bupivacaine 0.25% at 1.1 ml kg-1 (n=20). After caudal blockade inhalation Anaesthesia was stopped and Anaesthesia was maintained with a propofol infusion. Results: There were no significant differences between the groups with respect to sex distribution, age, weight, type of surgery, duration of Anaesthesia and surgery, and recovery time. None of patients developed a hemodynamic or respiratory problem. No nausea or vomiting was observed and no urinary retention was noted. The Anaesthesia onset time was shorter, the reached peak sensory level was higher, and duration of analgesia was longer in children receiving 1.1 ml kg-1. Total propofol consumption was statistically higher in children receiving 1.0 ml kg-1. Caudal Anaesthesia has been adequate to block the hernia pouch traction response during surgery in children receiving 1.1 ml kg-1. There were no significant differences between groups in the incidence of residual motor blockade. Conclusions: This study indicates that in children undergoing inguinal hernia repair surgery bupivacaine 0.25% at 1.1 ml kg-1 is more reliable.
