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Öğe Brain diffusion-weighted imaging in diabetic patients with retinopathy(Verduci Publisher, 2012) Dogan, M.; Ozsoy, E.; Doganay, S.; Burulday, V.; Firat, P. G.; Ozer, A.; Alkan, A.Objective: Our aim was to detect whether there is any change in apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the vision, in diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI). Materials and Methods: Conventional magnetic resonance imaging (MRI) and DWI of the brain were obtained from 45 diabetic patients (15 patients with proliferative diabetic retinopathy (group 1), 15 patients with nonproliferative diabetic retinopathy (group 2), 15 diabetic patients without retinopathy (group 3) and from 15 age-matched healthy volunteers (group 4). ADC values of visual cortex, cingulate gyrus, orbitofrontal, dorsomedial and dorsolateral frontal, corona radiate, and thalamus were obtained. Results: The ADC values of visual cortex, cingulate gyrus and orbitofrontal cortex significantly increased in groups 1 and 2 compared to groups 3 and 4 (p < 0.001). The ADC values of visual cortex significantly increased in group 1 compared to group 2 (p < 0.001). The duration of disease and value of HbA1c positively correlated with ADC values of the visual and orbitofrontal cortexes, and cingulate gyrus. Conclusions: We found an increase in ADC values supporting the neuronal loss in some regions, especially in visual center by DWI in the diabetic patients with retinopathy. This result supports the association between diabetic retinopathy and brain injury.Öğe Comparison of preoperative and postoperative anterior segment measurements with Pentacam in horizontal muscle surgery(Wichtig Editore, 2008) Emre, S.; Cankaya, C.; Demirel, S.; Doganay, S.PURPOSE. To evaluate the effect of horizontal muscle surgery (recession or recession plus resection) on the anterior chamber parameters in patients after strabismus surgery. METHODS. The Scheimpflug of 18 eyes of 12 patients with horizontal deviations were recorded just before surgery and 1 month after surgery. The power of anterior surface of cornea in horizontal and vertical axis, thinnest corneal thickness, anterior chamber depth, anterior chamber volume, and cornea volume were analyzed. The clinical characteristics of patients, the size of the deviations, the surgical doses, and observed responses to surgery were reviewed. RESULTS. There were six male and six female patients with an average age of 11.4 years (range, 4 to 22 years). Mean preoperative deviation was 47.91 PD (range, 20 to 75 PD), eight patients had esotropia with 57.5 PD average deviation (range, 40 to 75 PD), and four patients had exotropia with 28.75 PD average deviation (range, 20 to 35 PD). Of these 18 eyes, 12 eyes had horizontal muscle recession and 6 eyes had recession plus resection surgery. At the end of 1 month, three patients were orthophoric and eight patients had residual deviations varying between 16 and 35 PD. Preoperative and postoperative comparison of the whole study group documented insignificant changes in anterior chamber parameters and in keratometer readings. However, after dividing patients into two groups-recession or recession plus resection group-only one parameter, anterior chamber volume, was significantly reduced in recession plus resection group. CONCLUSIONS. Patients with strabismus who undergo recession plus resection procedure are prone to change in anterior chamber volume. Study with larger groups and long follow-up is necessary for clearer documentation of alterations at anterior chamber parameters.Öğe Corneal hysteresis in patients with dry eye(Nature Publishing Group, 2011) Firat, P. G.; Doganay, S.Purpose To measure corneal hysteresis and intraocular pressure (IOP) in patients with dry eye and to compare with normal subjects. Methods This cross-sectional study consists of 70 eyes of 40 patients with dry eye (group 1) and 75 eyes of 40 normal subjects (group 2). Eyes were diagnosed as dry eye or normal according to the clinical symptoms, biomicroscopical evaluation, and Schirmer test. Corneal hysteresis (CH), corneal resistance factor (CRF), and cornea-compensated intraocular pressure (IOPcc) were measured by the Ocular Response Analyser (ORA). Results Mean CH values were 10.56 +/- 0.25 mm Hg and 10.34 +/- 0.26 mm Hg, mean CRF values were 10.75 +/- 0.28 mm Hg and 10.70 +/- 0.28 mm Hg, mean CCT values were 542 +/- 3.20 mu m and 543 +/- 3.89 mu m in group 1 and group 2, respectively. There was no statistically significant difference between the groups for these three parameters. IOPcc values measured with ORA were 15.73 +/- 0.36 mm Hg in group 1 and 16.60 +/- 0.33 mm Hg in group 2, and there was no statistically significant difference between the two groups. Conclusions Corneal biomechanical parameters such as CH and CRF are not influenced in dry eye. Also statistical difference was not found between the two groups according to CCT and IOPcc values. Eye (2011) 25, 1570-1574; doi:10.1038/eye.2011.211; published online 9 September 2011Öğe Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study(Nature Publishing Group, 2012) Doganay, S.; Cankaya, C.; Alkan, A.Purpose To determine whether metabolite changes at cellular level occur in vitreous and lateral geniculate body (LGB) in patients with glaucoma by magnetic resonance spectroscopy (MRS). Methods A total of 29 eyes of 29 patients with glaucoma, no existing ocular pathology and systemic disease (group 1), and 13 eyes of 13 healthy individuals whose routine ophthalmological examinations were normal (group 2) were included in the study. Single-voxel MRS examination was performed by placing region of interest in vitreous and LGB. Glutamate-glutamine (Glx)/creatin (Cr) ratios and lactate peaks in the vitreous, and the Glx/Cr, N-acetyl aspartate (NAA)/Cr, choline (Cho)/Cr ratios in the ipsilateral area of LGB were evaluated. Results A statistically significant difference was found between the two groups for the Glx/Cr ratio in both the vitreous and LGB (P = 0.0001). There was no statistically significant difference between the two groups for the NAA/Cr, and Cho/Cr ratios in the LGB (P = 0.108). A lactate peak was established in the vitreous of 11 glaucoma patients. Conclusion Determining increased Glx/Cr ratios in both the vitreous and LGB of glaucoma patients, supports the theory of apoptosis in the etiopathogenesis of glaucoma. The MRS method, which can measure biochemical structures and metabolites of tissues, and also shows on a single spectrum, may be a new and non-invasive method for confirming the diagnosis of glaucoma and the role of apoptosis in the etiopathogenesis of glaucoma. Eye (2012) 26, 1044-1051; doi:10.1038/eye.2012.84; published online 25 May 2012Öğe The influence of soft contact lenses on the intraocular pressure measurement(Nature Publishing Group, 2012) Firat, P. G.; Cankaya, C.; Doganay, S.; Cavdar, M.; Duman, S.; Ozsoy, E.; Koc, B.Purpose To evaluate the influence of silicone hydrogel contact lenses on the intraocular pressure (IOP) measurement using Goldmann applanation tonometry (GAT), non-contact tonometry (NCT), and Pascal dynamic contour tonometry (DCT). Methods We included in the study 40 eyes of 40 patients who did not have any ocular or systemic diseases or contraindications to contact lens use. We measured and recorded the IOP values of each patient using NCT without and with contact lenses (groups 1 and 2, respectively), using DCT without and with contact lenses (groups 3 and 4, respectively), and using GAT without contact lenses (group 5). Results The mean IOP value of group 1 was 14.55 +/- 2.95 mmHg and 13.92 +/- 2.58 mmHg in group 2. We detected no statistically significant difference between group 1 and group 2 (P = 0.053). The mean IOP values for group 3 and group 4 were 16.26 +/- 2.33 mmHg and 15.19 +/- 2.40 mmHg, respectively. We detected a statistically significant difference between groups 3 and 4 (P = 0.005). Group 5's mean IOP value was 12.97 +/- 2.65 mmHg. IOP values measured with DCT were statistically significantly higher compared with IOP values measured with NCT and GAT (P < 0.0001 and P < 0.0001, respectively). Additionally, IOP values measured with NCT were statistically significantly higher compared with IOP values measured with GAT (P < 0.0001). Conclusion According to the results of our study, silicone hydrogel soft contact lens use does not significantly affect IOP values measured with NCT, but it affects IOP values measured with DCT. Eye (2012) 26, 278-282; doi:10.1038/eye.2011.271; published online 11 November 2011Öğe Polyurethane stent obstruction as a cause of recurrent epiphora - Case report(Edizioni Centauro, 2006) Doganay, S.; Sarac, K.; Miman, M. C.; Karadag, N.; Cokkeser, Y.A Song's nasolacrimal duct stent was placed in a patient with epiphora due to primary nasolacrimal duct obstruction and the stent was kept for 32 months. Mitomycin C 0.02% eye drops four times a day were prescribed for four weeks following polyurethane stent placement procedure. No epiphora-related complaints occurred for thirty months after then the epiphora started. Nasolacrimal stent was removed from nasal cavity endoscopially and the tissues within the extruded stent were examined histopathologically. The patient's complaints were relieved following stent removal. Dacryocystogram revealed normal passage and a filling defect within the lacrimal sac. Macroscopic evaluation of the stent revealed a firm mass in the stent mushroom, causing complete obstruction. Pathological examination of the mass revealed chronic inflammation, increased connective tissue and vascular proliferation. Nasolacrimal polyurethane stents can be removed easily by nasal approach. Nasolacrimal passage may be left open temporarily after stent removal. The use of Mitomycin C drop is a novel approach in nasolacrimal stent placement cases. However, when the long-term results of endoscopic and external dacryocystorhinostomy are considered, further research is needed on the biocompatibility of stent material.Öğe Silent Sinus Syndrome(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2009) Miman, M. C.; Akarcay, M.; Doganay, S.; Erdem, T.; Firat, Y.We present a case of silent sinus syndrome (SSS) who underwent unilateral surgical endoscopic maxillary meatotomy. Orbital floor reconstruction is delayed after follow up. Enophthalmos recovered 8 months after the surgery and radiologic findings improved. SSS is a clinical entity that should be kept in mind in the differential diagnosis of enophthalmos and can be treated successfully via endoscopic approach.Öğe Sub-Tenon's steroid irrigation for treatment of intraorbital capillary hemangioma(Sage Publications Inc, 2007) Firat, P. G.; Doganay, S.; Bilak, S.; Alkan, A.A four-month-old male infant underwent sub-Tenon's steroid irrigation for treatment of orbital capilary hemangioma that was causing exposure keratopathy risk to the left eye from progressive proptosis. The temporal inferior sub-Tenon's space was irrigated with a mixture of triamcinolone acetonide (40 mg/ml) and betamethasone sodium phosphate (6 mg/ml) by a blunt-tipped sub-Tenon's cannula. We describe this procedure as irrigation because reflux of the mixture from the incision was permitted. Two weeks after treatment, a marked reduction of proptosis was noted. One month after treatment, the volume of the intraorbital hemangioma resolved significantly in MRI examination. Steroid treatment can be applied local or systemically to treat orbital capillary hemangioma but side effects must be considered carefully. Sub-Tenon's steroid irrigation may be a benefical, effective, pratical and safe application route in the treatment of orbital capillary hemangiomas.
