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Öğe Adrenomedullin: Possible predictor of insulin resistance in women with polycystic ovary syndrome(Springer, 2012) Sahin, I.; Celik, O.; Celik, N.; Keskin, L.; Dogru, A.; Dogru, I.; Yurekli, M.The aim of the study was to investigate adrenomedullin (ADM) levels and its relation with insulin resistance in women with polycystic ovary syndrome (PCOS). Twenty-nine women with PCOS and 29 age- and body mass index (BMI)-matched control subjects were included in the study. PCOS was defined according to criteria by the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)-sponsored PCOS consensus workshop group. A full clinical and biochemical examination including basal hormones and metabolic profile was performed. Insulin resistance was calculated by using the homeostasis model assessment of insulin resistance index (HOMA-IR). Plasma ADM levels were measured by high performance liquid chromatographic (HPLC) method. Plasma ADM, fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS than the control group. ADM levels were positively correlated with insulin levels and HOMA-IR index. The best cut-off value of ADM levels to identify the presence of insulin resistance (HOMA-IR >= 2.7) was 30.44 ng/ml. Calculated odds ratio of insulin resistance by using logistic regression analysis, as predicted by ADM, was 0.15 (95% confidence interval, 0.037-0.628; p=0.009). In multiple regression analysis, ADM level was an independent predictor of HOMA-IR index. Our finding indicated that ADM levels increased in women with PCOS in accordance with HOMA-IR. ADM could be a significant independent determinant of insulin resistance in women with PCOS. (J. Endocrinol. Invest. 35: 553-556, 2012) (C) 2012, Editrice KurtisÖğe STIMULATED SUPEROXIDE DISMUTASE (SOD) ACTIVITY AND ENHANCED NITRIC OXIDE (NO) IN BEAN PLANT: THE EFFECT OF CADMIUM(Springer Heidelberg, 2004) Yurekli, F.; Porgali, Z. B.; Dogru, A.; Dogru, M., I; Yurekli, M.[Abstract Not Available]
