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Öğe Adrenomedullin Reduces Antioxidant Defense System and Enhances Kidney Tissue Damage in Cadmium and Lead Exposed Rats(Wiley, 2009) Yurekli, Muhittin; Esrefoglu, M.; Dogru, M. Ilker; Dogru, Arzu; Gul, M.; Whidden, M.Adrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found widely in the environment and they have important biological functions. Lead (Pb) and cadmium (Cd) can accumulate in the lungs, liver, bone, and kidneys and cause serious organ damage. In the present study, we investigated the effect of AdM, Pb + AdM, and Cd + AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney. Heavy metal accumulation was determined in kidney with and without AdM infusion and kidney damage was evaluated by light and electron microscopy. Increased heavy metal accumulation was observed in the heavy metal and AdM treated groups. SOD, CAT, GSH-Px activities, and MDA levels were significantly different in the treatment groups when compared with the control group. Tubular degeneration, necrosis, cell swelling, mononuclear cell infiltration, and degenerated organelles were observed in the kidney following treatment. Therefore, AdM infusion has no beneficial and/or compensatory role in cadmium and lead toxicity in the kidney. We conclude that heavy metal accumulation in the kidney in conjunction with AdM infusion is cytotoxic despite the known beneficial effects of adrenomedullin. (C) 2008 Wiley Periodicals, Inc. Environ Toxicol 24: 279-286, 2009.Öğe Circulating adrenomedullin levels in ankylosing spondylitis and Familial Mediterranean Fever(Elsevier France-Editions Scientifiques Medicales Elsevier, 2008) Ureten, Kemal; Ozbek, Mustafa; Ozturk, Mehmet Akif; Dogru, Ilker; Dogru, Arzu; Yurekli, Muhittin; Karakurt, FeridunIntroduction: Adrenomedullin (AM) is a 52-amino acid peptide with vasorelaxant properties. Apart from its roles on vascular tonus, AM can also contribute to inflammatory events. Plasma AM levels were elevated in connective tissue diseases and vasculitic disorders. Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine initiating in the sacroiliac joints. Familial Mediterranean Fever (FMF) is a hereditary disorder characterized by self-limiting acute attacks of fever and the presence of sustained subclinical inflammation in the attack-free periods. In this study, we investigated plasma AM levels in patients with AS and patients with FMF. Methods: Twenty AS patients with active disease manifestations (mean age: 41.6 +/- 10.9 years, female/male: 7/13), 28 FMF patients with acute attack (mean age: 27.4 +/- 10.7 years, female/male: 17/11), and 26 healthy controls (mean age: 39.9 +/- 5.5 years, female/male: 16/10) were enrolled in this study. AM levels were also measured in 11 FMF patients 2 months after the cessation of their attacks. AM levels of those 11 patients during their FMF attacks and attack-free periods were also compared. Results: Median plasma AM levels were 23.86 (17.24-40.09) pmol/mL, 27.33 (17.24-38.52) pmol/mL, and 26.11 (17.05-37.42) pmol/mL in AS patients, FMF patients with acute attack, and healthy controls, respectively (p > 0.05). AM levels were also similar in the attack-free periods of FMF patients [26.35 (24.35-34.14) pmol/mL]. There was no correlation between plasma AM levels and C-reactive protein, or between plasma AM levels and erythrocyte sedimentation rate. Conclusions: AM does not seem to have any role in the pathogenesis of AS and FMF. Previous reports of elevated levels of AM in connective tissue disorders and vasculitic diseases are probably disease specific, and AM does not seem to be a common component of inflammatory rheumatic disorders. (C) 2008 Elsevier Masson SAS. All rights reserved.Öğe The effects of adrenomedullin and methylated-adrenomedullin treatments on some antioxidative enzyme activities and malondialdehyde levels in rat liver(Federation Amer Soc Exp Biol, 2009) Yurekli, Muhittin; Esrefoglu, Mukaddes; Tumer, Nihal; Dogru, Ilker Mehmet; Gul, Mehmet; Dogru, Arzu; Yyldyrym, Nuran[Abstract Not Available]
