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Öğe The aging kidney: A 10-year renal biopsy study of geriatric population(2019) Sahinturk, Yasin; Sarikaya, Metin; Dolu, Suleyman; Kok, Mehmet; Inci, Ayca; Caliskan, Ali RizaAim: To report our experience with the renal biopsy/complications and histopathologic patterns of renal diseases according to their clinical presentation and to make the best disease management in the elderly patients. Material and Methods: Totally 136 patients were analyzed according to their renal biopsy histopathology, clinical diagnosis and biopsy related complications between 2006 and 2016.Results: Nephrotic syndrome (NS) and acute kidney injury (AKI) were the leading indications for renal biopsy. Totally 65 patients (47%) were diagnosed as NS and 60 patients (44%) were AKI. The most frequent histopathologic diagnosis was amyloidosis (30%). Membranous nephropathy (22%) was the second frequent histopathologic diagnosis. Amyloidosis (18.3%) was the leading cause of nephrotic syndrome and membranous nephropathy (17.6%) was the second most seen cause. Amyloidosis (11%) was the mostly seen histopathologic diagnosis of AKI. Back pain longer than 12 hours (10%) was the most common complication.Conclusion: According to our findings, renal disease of elderly differs from other age groups according to histopathologic distribution, early renal function loss and rapid progression to end stage renal disease. For an accurate early diagnosis and initiating specific treatment, renal biopsy should be performed on an individual basis without an increased risk for renal biopsy related complications.Keywords: Acute kidney injury; nephrotic syndrome; renal biopsy; elderly; renal histopathology.Öğe The aging kidney: A 10-year renal biopsy study of geriatric population(2019) Şahintürk, Yasin; Sarıkaya, Metin; Dolu, Suleyman; Kök, Mehmet; İnci, Ayça; Çalışkan, Ali RızaAim: To report our experience with the renal biopsy/complications and histopathologic patterns of renal diseases according to theirclinical presentation and to make the best disease management in the elderly patients.Material and Methods: Totally 136 patients were analyzed according to their renal biopsy histopathology, clinical diagnosis andbiopsy related complications between 2006 and 2016.Results: Nephrotic syndrome (NS) and acute kidney injury (AKI) were the leading indications for renal biopsy. Totally 65 patients(47%) were diagnosed as NS and 60 patients (44%) were AKI. The most frequent histopathologic diagnosis was amyloidosis (30%).Membranous nephropathy (22%) was the second frequent histopathologic diagnosis. Amyloidosis (18.3%) was the leading causeof nephrotic syndrome and membranous nephropathy (17.6%) was the second most seen cause. Amyloidosis (11%) was the mostlyseen histopathologic diagnosis of AKI. Back pain longer than 12 hours (10%) was the most common complication.Conclusion: According to our findings, renal disease of elderly differs from other age groups according to histopathologic distribution,early renal function loss and rapid progression to end stage renal disease. For an accurate early diagnosis and initiating specifictreatment, renal biopsy should be performed on an individual basis without an increased risk for renal biopsy related complications.Öğe The association of urotensin II with arterial stiffness and atherosclerosis in patients with autosomal dominant polycystic kidney disease(2019) Dolu, Suleyman; Coban, Melahat; Kilar Sozer, Yildiz; Erol, Bekir; Asilturk, Emre; Ellidag, Hamit YasarAim: Cardiovascular events are associated with increased mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Urotensin II (UT II) is the most potent vasoconstrictor peptide. The aim of the study was to investigate the relationship between UT II and arterial stiffness (AS) and atherosclerosis in ADPKD patients.Material and Methods: This cross-sectional study was conducted on 55 ADPKD patients with a mean age of 50 ± 14.4years. The presence of AS was determined with brachial-ankle pulse wave velocity (baPWV) and the presence of atherosclerosis was determined with carotid artery intima-media thickness (CA-IMT). Plasma UT II levels were determined by enzyme-linked immunosorbent assay.Results: Mean log10 UT II was 0.92±0.16 ng/mL. Mean baPWV and CA-IMT were 7.65±1.5 m/sec and 0.63±0.13 mm, respectively. Log10 UT II (p=0.009), baPWV (p 0.001) and CA-IMT (p=0.001) were high in patients compared to healthy individuals. There was an independent relationship between log10 UT II and creatinine (p=0.044) and spot urine protein-creatinine ratio (UPCR) (p=0.026) in multiple regression analysis. There was no relationship between log10 UT II and baPWV and CA-IMT.Conclusion: High plasma UT II levels were observed in ADPKD patients compared to healthy individuals. There was a relationship between UT II and kidney dysfunction and proteinuria. There was no relationship between UT II and AS and atherosclerosis.Keywords: Autosomal dominant polycystic kidney disease; arterial stiffness; atherosclerosis; urotensin ΙΙ.Öğe Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study(Kare Publ, 2024) Akarsu, Mesut; Dolu, Suleyman; Harputluoglu, Murat; Yilmaz, Sezai; Akyildiz, Murat; Gencdal, Genco; Polat, Kamil YalcinBackground and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.Öğe Covid-19 in Liver Transplant Recipients: A National Cohort(Elsevier, 2021) Kabacam, Gokhan; Turan, Ilker; Kiyici, Murat; Ellik, Zeynep Melekoglu; Dolu, Suleyman; Dayangac, Murat; Ari, Derya[Abstract Not Available]Öğe Fluctuation of liver transaminases with gluten-free diet compliance of a patient with celiac disease and autoimmune hepatitis; a case report(2017) Uyar, Seyit; Harmandar, Ferda; Gulenay, Suheyla Ayca; Zorlu Gorgulugil, Gizem; Koker, Gokhan; Cekin, Ayhan Hilmi; Dolu, SuleymanAlthough the association of celiac disease with autoimmune hepatitis is well-known, the effect of gluten-free diet on autoimmune hepatitis progression is poorly deafined. We described a patient with celiac disease coexisting with autoimmune hepatitis and effectiveness of gluten-free diet on both diseases. A young patient with eleveted serum liver transaminases was diagnosed as celiac disease and autoimmune hepatitis according to clinical, laboratory and pathological findings. Clinical complaints and laboratory findings of patients resolved exactly after glutenfree diet. However, liver transaminases eleveted and clinical manifestations re-emerged when he left the diet. Clinicians should consider that other autoimmune diseases may occur in the course celiac disease and gluten-free diet may improve also extra-intestinal manifestations of celiac disease.
