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    The Effects of COVID-19 Infection Control Measures on the Frequency of Rotavirus and Enteric Adenovirus in Children
    (Aves Yayincilik, Ibrahim Kara, 2022) Duman, Yuecel; Yakupogullari, Yusuf; Gunduz, Ayten
    Objective: The coronavirus disease 2019 pandemic has caused many changes in our lifestyle, such as the flow of our daily lives, communica-tion between individuals, traveling, eating, and drinking habits. These changes have reduced the risk of viral infections. In this study, it was aimed to examine the changes in the frequency of rotavirus and enteric adenovirus in children due to changes in lifestyle such as hand hygiene, physical distance and eating habits in individuals before and during the COVID-19 pandemic.Material and Methods: We analyzed data obtained from the labora-tory electronic records of hospitals in our region to assess the changes of rotavirus and adenovirus frequency and number of patients admit-ted to the hospital during the COVID-19 pandemic period compared to pre-pandemic years. Rotavirus and enteric adenovirus antigens were studied using a qualitative immunochromatographic method.Results: Between January 2018 and July 2021, a total of 68.504 patient samples were tested, 60.513 (88.3%) before the COVID-19 pandemic and 7991 (11.7%) during the pandemic. Mean age of the patients was deter-mined as 4.7 years. Before the pandemic, a total of 6.815 (11.3%) sam-ples for rotavirus and 1.873 (3.1%) samples for adenovirus were found positive. During the pandemic period, a total the 598 (7.5%) samples for rotavirus and 164 (2%) samples for adenovirus were found positive. Monthly median test numbers for rotavirus and adenovirus significant-ly fell about 75% (1.926 vs 493, p< 0.001). In addition, monthly median positivity rates of rotavirus (10.9% vs 7.1%, p= 0.002) and adenovirus (2.9% vs 1.8%, p< 0.001) reduced about 35% and 38%, respectively, after the onset of the pandemic as compared to the pre-pandemic years. The decrease in mean monthly test numbers and the reduction in the frequency of positive samples collectively indicated that the frequencies of both pathogens substantially reduced during the pandemic because of infection control measures.Conclusion: The fact that the COVID-19 pandemic forces us to comply with infection control rules and change our lifestyle shows us that these rules are very important not only in controlling the pandemic, but also in controlling other viral infections.
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    Retrospective Review of Patients with Staphylococcus aureus Bacteremia
    (Bilimsel Tip Yayinevi, 2024) Yilmaz, Zeynep Burcin; Duman, Yuecel; Altunisik Toplu, Sibel; Memisoglu, Funda; Kose, Adem; Ozden, Mehmet; Bayindir, Yasar
    Introduction: Staphylococcus aureus causes community-acquired and healthcare-associated infections with high morbidity and mortality. It is critical to initiate appropriate and effective treatment considering the risk factors for S. aureus bacteremia. There is insufficient data available regarding this patient group in our region. This study aimed to assess the focus of infection, resistance status, and clinical course in patients with S. aureus bacteremia detected in blood culture. Materials and Methods: Patients with healthcare-associated or community-acquired S. aureus bacteremia who were hospitalized in a tertiary hospital during the one year between January 2020 and December 2020, and microbiological data were retrospectively analyzed. The distribution of Staphylococcus aureus bacteremia was evaluated based on the organ involved, the clinics where it was observed, and its resistance status. Results: OStaphylococcus aureus isolate growth was detected in the blood cultures of 66 adult patients within one year. The mean age of the patients was 56.5 +/- 16.8 (18-84) years, and 76% were male. While bacteremia was community-acquired in 12 (18.2%) of the patients, it was healthcare-related in 54 (81.8%) and methicillin resistance rates were 8.3% and 25.9%, respectively. The most common focus of infection was catheter-related bloodstream infection in 21.2% and pneumonia in 21.2% of patients. No focus was detected in 34.8% of the bacteremias. In terms of methicillin-resistant S. aureus (MRSA) distribution, the difference between intensive care and wards was 20% and 80%, respectively. No statistically significant difference was found (p> 0.05). While the 14-day mortality in MRSA bacteremia was 33.6%, the 14-day mortality in methicillin-susceptible S. aureus was 27.5% (p= 0.731). Conclusion: It was found that Staphylococcus aureus bacteremia was predominantly nosocomial, with pneumonia and catheter infections being the most common causes. The conclusion drawn suggests a need for heightened infection control measures, particularly focusing on improving hand hygiene practices. To guide empirical treatment effectively, it is crucial to monitor resistance changes that may have occurred over the years, consider risk factors for MRSA, and elucidate the resistance profiles specific to individual healthcare facilities.