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Öğe The burden of scoliosis: a nationwide database study on demographics, incidence, and surgical rates(Springer, 2024) Saglam, Yavuz; Bingol, Izzet; Yasar, Niyazi Erdem; Dumlupinar, Ebru; Ata, Naim; Ulgu, M. Mahir; Birinci, SuayipIntroduction Scoliosis is characterized as a three-dimensional deformity of the spine, affected by variety of factors, including biological, mechanical, hormonal, and genetics.Methods Our study's primary objective was to delineate the demographics, incidence, and prevalence of scoliosis from a nationwide perspective, analyze the surgical intervention rates, with the aim of offering more insightful guidance to orthopedic physicians. This nationwide cohort study was conducted from digital database for healthcare information management. Relevant population data, for children under 18 years old, was extracted from the official government census within the period of January 2015 to December 2022. Utilizing diagnostic code of M41 [Scoliosis] was used to define the patient pool from ICD-10. Demographic variables, type of operations (posterior only, anterior only, or combined), and complications were documented. Incidence and prevalence values were calculated using population figures and case numbers.Result There were 276,521 patients with an average incidence of 129 per 100,000. Frequency of females was 1.45 times greater than that of males (p < 0.001). A total of 10,417 surgeries were performed in 10,311 patients during the inspection period (3.8% of all cases). Posterior fusion was by far the most common surgical approach (n = 10.111; 97%) followed by anterior fusion (n = 200; 1,9%).Conclusions Our findings reveal a significant increase in the average incidence of scoliosis diagnosis, rising from 107 per 100,000 individuals in 2015 to 161 per 100,000 in 2022. Scoliosis now impacts an estimated 1.2% of children and adolescents in Turkey. The risk is 1.45 times higher in females than in males.Öğe Epidemiology and demographics of pediatric proximal femur fractures in Türkiye: results from a government-based health registry(Lippincott Williams & Wilkins, 2024) Soylemez, Mehmet Salih; Bingol, Izzet; Yasar, Niyazi Erdem; Dumlupinar, Ebru; Ayvali, Mustafa Okan; Ata, Naim; Ulgu, M. MahirWe evaluate the epidemiology and incidence of pediatric proximal femur fractures, treatment trends among different hospital levels, and complication rates among different treatment modalities by examining a national health registry in T & uuml;rkiye. The health records of individuals aged <= 16 years admitted to public, private, and university hospitals were collected via the e-health database of the Turkish Ministry of Health. A total of 2388 children treated for proximal femur fractures from 2016 to 2021 with at least 2 years of follow-up were included in the study. While 2033 (85.1%) patients were treated with closed reduction and spica casts, 355 (14.8%) were operated on. Mean age was 8.603 +/- 5.11 years. Male incidence was 2-fold greater compared to female patients (36.4% female and 63.6% male patients; P < 0.001). The frequency of cases was significantly increased in the age groups of 3-4 and 13-16 years. Comorbidities causing limited ambulation were detected in 6.5% of all cases, and 163 (8.0%) patients in the conservative group and 98 (27.6%) patients in the surgery group had at least one complication. The incidence was 0.45 per 100 000 children aged <= 16 years. This study reports the largest patient cohort to date, providing evidence on the epidemiology and incidence of pediatric proximal femur fractures using health registry data. We have found that the most common treatment modality for proximal femur fractures is closed reduction with spica casts. The rate of avascular necrosis is similar among patients treated surgically and those treated conservatively.Öğe Protective Effect of Curcumin Against the Toxic Effect of Acrylamide on the Rat Hippocampus(Springernature, 2025) Cetin, Seda; Ozbag, Davut; Ogeturk, Murat; Dogan, Zumrut; Annac, Ebru; Dumlupinar, Ebru; Erdemli, Mehmet ErmanBackgroundThis study aimed to investigate the neurotoxic effects of acrylamide (AA) on the hippocampus and the potential protective effects of curcumin (CUR), a potent antioxidant, to attenuate these effects. Despite the lack of information in the literature regarding the volumetric effects of AA on the hippocampus, our study aimed to clarify this issue through stereological measurements, alongside histological and biochemical analyses.MethodsSprague-Dawley rats (similar to 250 g) were allocated into four groups: Control, AA, CUR, and AA + CUR. Both AA (50 mg/kg, intraperitoneally) and CUR (300 mg/kg, orally via gavage) were administered daily for 12 consecutive days. Following the treatment period, tissue samples were collected. Stereological, histological, and biochemical analyses were performed on the hippocampal tissue.ResultComparison of AA experimental groups data and control group data revealed that while the malondialdehyde (MDA) levels in the hippocampus increased significantly, Brain-derived neurotrophic factor (BDNF) and Glutathione (GSH) levels decreased. The results showed that CUR was effective on these levels. Histopathologically, neurons exhibited degeneration and hemorrhagic damages. According to the Cavalieri calculation, a stereological method applied to the experimental groups, no significant variation was found between the groups.ConclusionsWe determined that CUR minimizes the possible toxic effects of AA on the rat hippocampus. When the hippocampus areas were examined stereologically, we determined that it wasn't affected from this relation. We think that this was due to the short duration of our study.Öğe Protective Effect of Curcumin Against the Toxic Effect of Acrylamide on the Rat Hippocampus (may, 10.1007/s44411-025-00171-z, 2025)(Springernature, 2025) Cetin, Seda; Ozbag, Davut; Ogeturk, Murat; Dogan, Zumrut; Annac, Ebru; Dumlupinar, Ebru; Erdemli, Mehmet Erman[No abstract available]
