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Öğe Accidental Displacement of Dental Implants Into Both Maxillary Sinuses During Surgery(Allen Press Inc, 2015) Eltas, Abubekir; Dundar, Serkan; Eltas, Seydanur Dengizek; Altun, Oguzhan; Yolcu, Umit; Saybak, Arif[Abstract Not Available]Öğe Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants(Springer Japan Kk, 2021) Tekin, Samet; Dundar, Serkan; Demirci, Fatih; Bozoglan, Alihan; Yildirim, Tuba Talo; Gunes, Nedim; Acikan, IzzetBackground This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants. Material and methods After surgical insertion of titanium implants into the metaphyseal part of rats' both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation. Results One-way analysis of variance and Tukey's honestly significant difference test and Student's t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05). Conclusions Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.Öğe Biomechanical Evaluation of Implant Osseointegration After Guided Bone Regeneration With Different Bone Grafts(Lippincott Williams & Wilkins, 2021) Gunes, Nedim; Gul, Mehmet; Dundar, Serkan; Tekin, Samet; Bozoglan, Alihan; Ozcan, Erhan Cahit; Karasu, NecmettinThe aim of this study was to compare the biomechanical osseointegration of titanium implants after guided bone regeneration (GBR) with a hydroxyapatite graft, deproteinized bovine bone graft, human-derived allograft, and calcium sulfate bone graft. Thirty-two female Sprague Dawley rats were divided into four groups, each containing eight (n = 8) rats: hydroxyapatide (HA), deproteinized bovine bone graft (DPBB), allograft (ALG), and calcium sulfate. Bone defects were created in the tibia of the rats, which were grafted with HA, DPBB, ALG, or CP bone grafts for the purpose of GBR. Ninety days after surgery, machine-surfaced titanium implants were inserted into the area where GBR had been undertaken. After 90 days of the surgical insertion of the implants, the rats were sacrificed, the implants with surrounding bone tissue were removed, and biomechanical osseointegration (N/cm) analysis was performed. No statistically significant differences were found among the groups in osseointegration (N/cm) three months after the GBR procedures (P > 0.05). According to the biomechanical results, none of the grafts used in this study was distinctly superior to any of the others.Öğe Comparison of the Effects of Local and Systemic Zoledronic Acid Application on Mandibular Distraction Osteogenesis(Lippincott Williams & Wilkins, 2017) Dundar, Serkan; Artas, Gokhan; Acikan, Izzet; Yaman, Ferhan; Kirtay, Mustafa; Ozupek, Muhammed Fatih; Asutay, FatihBisphosphonates are antibone resorptive drugs that are used to prevent bone tissue resorption in several skeletal diseases. The aim of this study was to examine the effects of systemic and local applications of zoledronic acid (ZA) on newly regenerated bone in a model of experimental distraction osteogenesis (DO). To do this mandibular DO was applied to 30 adult female Sprague Dawley rats, which were randomly divided into 3 groups: control, DO only, systemic zoledronic acid (SZA), and local zoledronic acid (LZA). In the LZA group, the gap between the bone fragments was filled with a gelatin sponge soaked in 2mg of ZA and 0.1 mL of sterile saline. In the SZA group, a single dose of 0.1 mg/kg ZA was administered systemically. After the surgery, there was a 5-day latent waiting period and 10-day distraction phase. Following a 28-day consolidation period, the rats were euthanized and theirmandibles were collected. The distracted bone area was seen to be filled with newly regenerated bone tissue in all 3 groups, both histologically and histomorphometrically. In addition, amounts of new bone formation, osteoblast cella, osteoclast (OC) cells, osteopontin, and vascular endothelial growth factor in the SZA and LZA groups were found to be higher when compared with the controls. Furthermore, in the SZA group, new bone formation, osteoblast, OC, osteopontin, and vascular endothelial growth factor were detected in significant amounts compared with the LZA group. Osteoclast numbers did not differ in a statistically significant manner in the SZA group with respect to the LZA group. Based on the results of this study, systemic and local applications of ZA could increase the formation of new bone in patients of DO, and systemic application is a more effective method compared with local application.Öğe Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis(Dove Medical Press Ltd, 2016) Dundar, Serkan; Eltas, Abubekir; Hakki, Ema S.; Malkoc, Siddik; Uslu, M. Ozay; Tuzcu, Mehmet; Komorowski, JamesThe purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects. Fifty two 8-week-old female Sprague Dawley rats were equally divided into four groups. The control group included those fed a standard rat diet with no operation performed during the experiment. The periodontitis, ASI I, and ASI II groups were subjected to experimental periodontitis induction for 11 days after being fed a standard rat diet alone, a diet containing 1.81 g/kg ASI complex, or a diet containing 3.62 g/kg ASI complex, respectively, for 8 weeks. Throughout the 11-day duration of periodontitis induction, all rats were fed standard feed. The rats were euthanized on the eleventh day, and their tissue and blood samples were collected. In the periodontitis group, elevated tissue destruction parameters and reduced tissue formation parameters were found, as compared to the ASI groups. Levels of enzymes, cytokines, and mediators associated with periodontal tissue destruction were lower in rats fed a diet containing ASI complex after experimental periodontitis. These results indicate that ASI complex could be an alternative agent for host modulation.Öğe Displacement of Dental Implant Into the Submental Space After Surgical Integration(Lippincott Williams & Wilkins, 2017) Kirtay, Mustafa; Yolcu, Umit; Dundar, SerkanOsseointegrated dental implants are common and widely used to treat edentulism. Implant displacement into the maxillofacial spaces during surgery or after a period of use is a complication recognized in the literature. Foreign objects such as titanium dental implants in the maxillofacial region must be removed because they cause infection due to tissue reaction. In this report, the authors present the case of a patient whose dental implant slipped into the submental space after surgical integration and describe the surgical removal of the implant via an extraoral approach.Öğe Effect of micro-arc oxidation coatings with graphene oxide and graphite on osseointegration of titanium implants-an in vivo study(Elsevier, 2024) Tekin, Bahar; Dundar, Serkan; Tekin, Samet; Sukuroglu, Ebru Emine; Khurshid, Zohaib; Ezgi, Yusuf; Demirci, FatihBackground: This in vivo study evaluated the effect of graphene oxide and graphite coatings, coupled with the micro-arc oxidation (MAO) surface roughening technique, known for their mechanical strength, chemical stability, and antibacterial properties. The main objective was to assess the degree of improvement in osseointegration of titanium implants resulting from these interventions. Materials and methods: In this study, 32 female rats were utilized and randomly allocated into four groups (n = 8 each): machined surface titanium implants (control), those roughened by the MAO method, those coated with graphene oxide-doped MAO, and those with a graphite-doped MAO coating. Titanium implants were surgically placed in the right tibia of the rats. Rats undergoing no additional procedures during the 4-week experimental period were sacrificed at the end. Then, the implants and surrounding bone tissues were separated and embedded in acrylic blocks for reverse torque analysis. Using a digital torque device, the rotational force was applied to all samples using a hex driver and racquet until implant separation from the bone occurred, with the corresponding values recorded on the digital display. Then, statistical analysis was performed to analyze the data. Results: No statistically significant difference between the groups was observed in the biomechanical bone-implant connection levels (N/cm) (P = 0.268). Post-hoc tests were not required because no discernible differences were identified between the groups. Conclusion: Within the scope of this study, implants treated with the MAO method, along with those coated with graphene oxide- and graphite-doped MAO method, did not exhibit significant superiority in terms of osseointegration compared to machined surface titanium implants.Öğe Effects of Different Levels of Restraint Stress on Bone-Implant Contact(Lippincott Williams & Wilkins, 2019) Bozoglan, Alihan; Dundar, Serkan; Yildirim, Tuba T.; Bulmus, Ozgur; Ertugrul, Abdullah Seckin; Bozoglan, Merve Y.; Tekin, SametThis study examined the effects of different levels of chronic restraint stress on bone-titanium implant contact in rats. This study included 32 adult female Sprague-Dawley rats. The machined surface titanium implants were surgically placed into the metaphyseal region of the rat tibias. Next, the rats were divided randomly into 4 groups, namely, control (CNT) (n = 8), low-restraint stress (LRS) (n = 8), medium-restraint stress (MRS) (n = 8), and high-restraint stress (HRS) (n = 8) groups. The rats in the CNT group received only the titanium implants surgically but did not receive any further treatment during the experimental period of 30 days. The rats in the LRS, MRS, and HRS groups were applied restraint stress for 1, 2, and 4 hours, respectively, daily for 28 days starting from day 2 after the surgery. At the end of the study period, the rats were sacrificed and their implants and the surrounding bone tissues were harvested for performing non-decalcified histological analysis. Moreover, blood samples were collected from the rats and were centrifuged for analyzing serum cortisol levels. Serum cortisol levels of the rats in the LRS, MRS, and HRS groups were higher than those of the rats in the CNT group (P<0.05). Moreover, serum cortisol levels of the rats in the HRS group were higher than those of the rats in the MRS and LRS groups (P<0.05). The extent of bone-implant contact was lower in the rats in the HRS group than in the rats in the CNT and LRS groups (P<0.05). These data suggest that the application of 4-hour chronic restraint stress during the 28-day experimental period impaired the bone-implant contact.Öğe Effects of diode laser application on inflammation and mpo in periodontal tissues in a rat model(Univ Sao Paulo Fac Odontologia Bauru, 2018) Uslu, Mustafa Ozay; Eltas, Abubekir; Marakoglu, Ismail; Dundar, Serkan; Sahin, Kazim; Ozercan, Ibrahim HanifiObjective: In this study, we aimed to histologically and immunologically evaluate the effect of diode laser treatment when applied adjunctive to scaling and root planing (SRP) in an experimental periodontitis model. Materials and methods: We used Wistar-Albino rats (n=60) with average weight of 230 g. Experimental periodontitis was induced by ligature at the right and left first mandibular molar teeth in all rats. After 11 days, the ligature was removed and rats were divided into two groups. The control group (n=30) received only SRP treatment, while the laser group (n=30) received a diode laser (GaAlAs, 810 nm, 1 W, 10 J, 20 s) treatment adjunctive to SRP. Ten rats in each group were sacrificed after 7, 15, and 30 days. Histopathological examination was performed in the left mandible of rats. Myeloperoxidase (MPO) was evaluated by western blot in the gingival specimens from the right mandible. Results: MPO levels in the laser group were statistically significantly lower compared with the control group (p <= 0.05). There was no statistically significance at any time between MPO levels in the control group (p>0.05). MPO levels in the laser group at the 7th day were statistically significantly higher compared to the 15th (p <= 0.05) and the 30th day (p <= 0.05). Inflammatory cell infiltration decreased over time in both groups and was statistically significantly lower in the laser group than in the control group at all times (p <= 0.01). Conclusions: Within the limits of this study, we suggest that diode laser application is an adjunctive treatment because it reduced inflammation and MPO when applied in addition to SRP. On the other hand, more studies are needed for the assessment of the effects of diode laser application to periodontal tissues.Öğe The effects of high-fat diet on implant osseointegration: an experimental study(Korean Acad Oral & Maxillofacial Surgery, 2016) Dundar, Serkan; Yaman, Ferhan; Ozupek, Muhammed Fatih; Saybak, Arif; Gul, Mehmet; Asutay, Fatih; Kirtay, MustafaObjectives: In this study, we investigated whether a high-fat diet (HFD) affected the bone implant connection (BIC) in peri-implant bone. Materials and Methods: Four male rabbits were used in this study. Dental implant surgery was introduced into each tibia, and four implants were integrated into each animal. In both the normal diet (ND) group (n=2) and HFD group (n=2), 8 implants were integrated, for a total of 16 integrated implants. The animals continued with their respective diets for 12 weeks post-surgery. Afterward, the rabbits were sacrificed, and the BIC was assessed histomorphometrically. Results: Histologic and histomorphometric analyses demonstrated that BIC was not impaired in the HFD group compared to the ND group. Conclusion: Within the limitations of this study, we found that HFD did not decrease the BIC in rabbit tibias.Öğe Effects of Local and Systemic Zoledronic Acid Application on Titanium Implant Osseointegration: An Experimental Study Conducted on Two Surface Types(Lippincott Williams & Wilkins, 2017) Dundar, Serkan; Yaman, Ferhan; Gecor, Orhan; Cakmak, Omer; Kirtay, Mustafa; Yildirim, Tuba Talo; Karaman, TahirThe aim of this study was to evaluate the effects of local and systemic zoledronic acid (ZA) applications on titaniumoksit ceramic blasted (TiO-CB)- and sandblasted large acid-grit (SLA)-surfaced titanium implant osseointegration. Twelve New Zealand White rabbits were used in the study, divided into 6 groups: the TiO-CB (TiO-CB-CNT) (n = 2) and SLA (SLA-CNT) (n = 2) control groups in which TiO-CB- and SLA-surfaced titanium implants were surgically inserted into rabbit tibias but no treatment was applied; the TiO-CB (TiO-CB-LZA) (n = 2) and SLA (SLA-LZA) (n = 2) local ZA groups in which 1 mL of normal saline solution containing 2 mg of ZA was injected into sockets and after this the implants were integrated; and the TiO-CB (TiO-CB-SZA) (n = 2) and SLA (SLA-SZA) (n = 2) systemic ZA groups in which a single infusion of 0.1 mg/kg of ZA was administered during surgical implant insertion. Following a period of osseointegration, bone implant contact (BIC) was recorded as a proportion of the total implant surface length in direct contact with the bone. Results of this study indicate that BIC was greater in the systemic ZA application groups than in the local ZA application groups, and BIC was greater in the local ZA groups than in the controls. Statistically significant differences in BIC were not detected between the TiO-CB- and SLA-surfaced implants in all the groups. Furthermore, this study did not reveal significant differences between the 2 types of surfaces due to similar average roughness values. Overall, systemic ZA application was found to be more effective in increasing BIC than local ZA application based on the results obtained by testing 2 implant surfaces.Öğe Effects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental study(Sociedade Brasileira De Pesquisa Odontologica, 2020) Dundar, Serkan; Bozoglan, Alihan; Bulmus, Ozgur; Tekin, Samet; Yildirim, Tuba Talo; Kirtay, Mustafa; Toy, Vesile ElifThis study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.Öğe Evaluation of Effects of Topical Melatonin Application on Osseointegration of Dental Implant: An Experimental Study(Allen Press Inc, 2016) Dundar, Serkan; Yaman, Ferhan; Saybak, Arif; Ozupek, M. Fatih; Toy, Vesile Elif; Gul, Mehmet; Ozercan, I. HanifiThe aim of the present study was to evaluate the effect of local melatonin application during surgery on bone implant connection (BIC) in rabbit tibiae. Six 0.8- to 1-year-old male New Zealand rabbits were divided into 3 groups: (1) a control group (CG) in which rabbits were not treated with additive materials and only implant integration was executed; (2) a melatonin dose 1 (MLT D-1) group in which rabbits were treated with 1.2 mg of melatonin locally before implant placement into the rabbits' tibiae; and (3) a melatonin dose 2 (MLT D-2) group in which rabbits were treated with 3 mg melatonin locally before implant placement into the rabbits' tibiae. Four weeks after the procedure, the rabbits were euthanized; their tibiae were dissected from muscles and soft tissues, fixed with formaldehyde, and later embedded in methacrylate. Histologic and histomorphometric analyses were then performed under light microscopy. Following this, BIC was detected histomorphometrically, and P<.05 was considered statistically significant. Results showed that the highest BIC percentage was detected in MLT D-2, with a mean value of 39.46% +/- 0.78, as compared with a mean value of 33.89% +/- 0.92 in group MLT D-1 and 27.42% +/- 0.89 in CG. Similarly, the mean BIC percentage of the MLT D-2 group was the highest among the three, with the mean BIC percentage of the MLT D-1 still registering as higher than CG. Within the limitations of this rabbit study, it appears that local melatonin application during implant surgery may improve BIC.Öğe Guided bone regeneration with polyethylene membrane, zoledronic acid and hydroxiapatide bone graft in peri-implant bone defect: An experimental study(Allied Acad, 2017) Yaman, Ferhan; Dundar, Serkan; Cakmak, Omer; Saybak, Arif; Kirtay, Mustafa; Kaya, Beyza; Kom, MustafaThis study aimed to determine the guided bone regeneration (GBR) capacity of peri-implant bone defect treatment, either with only a hydroxyapatite bone graft or with a hydroxyapatite bone graft mixed with zoledronic acid (ZA) and employing polyethylene glycol (PEG) barrier membranes. In this study, four male New Zealand rabbits were used. First, the rabbits were randomly divided into two groups, the hydroxyapatite graft group (HA) (n=2) and the HA graft + zoledronic acid group (HA+ZA) (n=2). For the HA group, peri-implant GBR was performed with only an HA bone graft, and a resorbable PEG barrier membrane was placed over each surgical defect to cover the peri-implant bone defects. For the HA+ZA group, peri-implant GBR was performed with an HA bone graft that had previously been mixed with ZA. A resorbable PEG barrier membrane was placed over each surgical defect to cover the peri-implant bone defects. Experiments were performed using a standardised peri-implant bone tissue defect model in rabbit tibia for 60 days. Circumferential defects were surgically induced around the dental implants on the tibias of four rabbits. Sixty days after the surgical procedures, the rabbits were sacrificed, and their tibias with the graft sites were harvested for histologic evaluation. In the HA+ZA group, significantly more new bone formation was detected as compared with the HA group (P<0.05). Within the limitations of this study, locally administered ZA with an HA synthetic graft and PEG membrane was a more effective method as compared to using only a graft in a peri-implant GBR procedure. Additionally, a PEG membrane should be useful in GBR as a barrier membrane. Further studies are needed to confirm these results.Öğe Is there a relation between dental anxiety, fear and general psychological status?(Peerj Inc, 2017) Yildirim, Tuba Talo; Dundar, Serkan; Bozoglan, Alihan; Karaman, Tahir; Dildes, Neval; Kaya, Filiz Acun; Altintas, EyyupBackground. Dental anxiety is a widespread problem in many populations. This problem can be a barrier to dental care and may lead to poor oral health. Dental anxiety may be related to psychological status. Aims. The aim of the present study was to assess the levels of dental anxiety, dental fear, Beck Depression, and state-trait anxiety according to age, gender and education level in patients at the periodontology clinic in the Diyarbak?r Mouth and Dental Health Center. Study Design. A total of 231 patients (115 males, 116 females) filled out dental fear scale (DFS), dental anxiety scale (DAS), Beck Depression Inventory (BDI), state-trait anxiety inventory-state (STAI-S), and state-trait anxiety inventory-trait (STAI-T) questionnaires, and evaluations of DFS, DAS, BDI, STAI-S, and STAI-T were conducted according to age, gender, and education level. Results. The mean DFS, DAS, BDI, STAI-T, and STAI -S were 45.64, 9.15, 13.16, 38.90, and 40.18, respectively. There was a significant association among DFS, DAS, BDI, STAI-S, and STAI-T (p < 0.05). These surveys scores were significantly higher in females than males (p < 0.05). The results of this study indicated that gender age and education level have important effects on DFS, DAS, BDI, STAI-S, and STAI-T (p < 0.05). Conclusion. Dental anxiety and dental fear were found to be related to psychological status (BDI, STAI-S, and STAI-T) over time. There are some patients with unaddressed psychological distress.Öğe Theoretical and experimental characterization of Pr/Ce co-doped hydroxyapatites(Elsevier, 2021) Ibrahimzade, Lala; Kaygili, Omer; Dundar, Serkan; Ates, Tankut; Dorozhkin, Sergey V.; Bulut, Niyazi; Koytepe, SuleymanThis study presents a more extensive report on the experimental and theoretical characterization of the Ce-doped hydroxyapatite (HAp) samples additionally doped with Pr at varying amounts. To achieve this goal, four Ce-containing (a constant amount of 0.35 at.%) HAps additionally doped with Pr at various amounts (0.35, 0.70, 1.05, and 1.40 at.%) were synthesized via a combustion method. Besides, all these samples were modeled theoretically by using a density functional theory (DFT). Theoretical results showed that the bandgap energy decreased continuously from 4.5156 to 4.3097 eV. For all samples, the linear attenuation (or absorption) coefficient increased with the increasing amount of Pr and this parameter had a decreasing trend with the increase in the photon energy. An increase in the theoretical density and the lattice parameter c and a decrease of both the lattice parameter a and the unit cell volume were found. After analyzing the experimental data, the following results were observed: X-ray diffraction (XRD) and Fourier transform infrared (FTIR) data verified the formation of HAp phase (above 94% for all the samples) as the major phase and beta-tricalcium phosphate (beta-TCP) as the minor one. The amount of beta-TCP phase was found to increase from 3.4 to 5.9% with the addition of Pr. Similar to the theoretical findings, an increasing trend for the density and decreasing one for the unit cell volume were detected. Both a decrease in the crystallinity and an increase in the anisotropic energy density were found. The results of the thermal analysis supported the thermal stability of all the samples. The cell viability was found to be affected by Pr-content. (C) 2021 Elsevier B.V. All rights reserved.
