Yazar "Durak, Akif" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Acute Subdural Hematomas Caused by Ruptured Aneurysms: Experience from a Single Turkish Center
    (Turkish Neurosurgical Soc, 2009) Kocak, Ayhan; Ates, Ozkan; Durak, Akif; Alkan, Alpay; Cayli, Suleyman; Sarac, Kaya
    AIM: Although an aneurysmal rupture typically presents on computed tomography (CT) imaging as only a subarachnoid hemorrhage (SAH), it may be associated with spontaneous (nontraumatic) subdural hemorrhage (sSDH). The purpose of this paper is to discuss the clinical and radiological characteristics, as well as a potentially dangerous situation in the diagnosis and the management of this life-threatening condition. MATERIAL and METHODS: The Department of Neurosurgery at Inonu University (Turgut Ozal Medical Center) (TOMC) maintains a prospective database of all patients treated for intracranial aneurysms since 1999. Using this database, we obtained patients with ruptured aneurysms who presented with sSDH on CT imaging. RESULTS: 687 patients with radiographically documented ruptured aneurysms were admitted from January 2000 through January 2009. Of these, eleven patients presented with sSDH. The incidence of aneurysmal rupture with sSDH is 1.6% in our series. CONCLUSION: Acute sSDH on cranial CT should be considered for an urgent workup of a ruptured aneurysm, even in the absence or presence of SAH finding. CT angiography has advantages over cerebral digital substraction angiography (DSA) and may be a reasonable alternative to latter modality in the diagnosis, triage, and treatment planning in patients with sSDH.
  • Küçük Resim
    Öğe
    Kafa tabanı tümörlerinde helikal tomoterapi ile uygulanan yoğunluk ayarlı ve görüntü eşliğinde radyoterapi: iki olgu sunumu
    (İnönü Üniversitesi Tıp Fakültesi Dergisi, 2015) Ekici, Kemal; Temelli, Öztun; Ekici, Cemal; Durak, Akif
    Kafa tabanı tümörlerinde cerrahi uygulanmazsa prognoz kötüdür ve tedavi çoğunlukla primer hastalığı kontrol altına alıp hasta için tatminkar yaşam kalitesi sağlamayı amaçlar. Kliniğimize başvuran 2 kafa tabanı tümörüne helikal tomoterapi ile uygulanan yoğunluk ayarlı radyoterapi sonuçları tartışılmıştır. Her iki hastamızda da subjektif yakınmalarda azalma görülmüştür. Hastalarımıza ortalama 54 Gy radyoterapi uygulanmıştır Bu makalede kafa tabanı tümörü nedeniyle cerrahi rezeksiyon uygulanamayan 2 hastada helikal tomoterapinin etkinliği tartışılmaya çalışılmıştır.
  • Küçük Resim Yok
    Öğe
    Neuroprotective effect of mexiletine in the central nervous system of diabetic rats
    (Springer, 2006) Ates, Ozkan; Cayli, Suleyman R.; Altinoz, Eyup; Yucel, Neslihan; Kocak, Ayhan; Tarim, Ozcan; Durak, Akif
    Both experimental and clinical studies suggests that oxidative stress plays an important role in the pathogenesis of diabetes mellitus type I and type 2. Hyperglycaemia leads to free radical generation and causes neural degeneration. In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord. 30 adult male Wistar rats were divided into three groups: control, diabetic, and diabetic-mexiletine treated group. Diabetes mellitus was induced by a single injection of streptozotocin (60 mg/kg body weight). Mexiletine (50 mg/kg) was injected intraperitoneally every day for six weeks. After 6 weeks the brain, brain stem and cervical spinal cord of the rats were removed and the hippocampus, cortex, cerebellum, brain stem and spinal cord were dissected for biochemical analysis (the level of Malondialdehide [MDA], Nitric Oxide [NO], Reduced Glutathione [GSH], and Xanthine Oxidase [XO] activity). MDA, XO and NO levels in the hippocampus, cortex, cerebellum, brain stem and spinal cord of the diabetic group increased significantly, when compared with control and mexiletine groups (P < 0.05). GSH levels in the hippocampus, cortex, cerebellum, brain stem and spinal cord of the diabetic group decreased significantly when compared with control and mexiletine groups (P < 0.05). This study demonstrates that mexiletine protects the neuronal tissue against the diabetic oxidative damage.