Yazar "Duran, Ali" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Is phenytoin a safe agent for staple line recovery after gastric sleeve surgery in rats?
    (Turkish Assoc Trauma Emergency Surgery, 2023) Gay, Ferhat; Duran, Ali; Tokay, Esra; Hacioglu, Nelin; Kockar, Feray; Altun, Eren; Kanat, Burhan Hakan
    BACKGROUND: The most challenging and mortal complication of gastric sleeve surgery (SG) is staple line leakage. Although many agents have been used for increasing tissue healing on the stapler line, there is still no consensus on its effectiveness and efficacy. The aim of study is to determine the effect of phenytoin on the healing process of gastric sleeve surgery in rats. METHODS: On the 10th post-operative day, the effects of phenytoin on bursting pressure in the stapler line were evaluated alongside pathohistological examinations. To investigate the molecular impact of phenytoin on the expression of TGF-8, VEGF, FGF2, and p53 genes, quantitative real-time polymerase chain reaction was utilized. In addition, gene expressions at the protein level were determined by immunohistochemical analysis. RESULTS: No signs of intra-abdominal leakage were observed in the resected samples. A statistically essential extend in stable bursting pressure measure was observed between the control group and the group treated with phenytoin application. Pathohistological results indicate that the mean score of collagens of the study group (3.2 +/- 0.42) was significantly higher than the control group (2.3 +/- 0.48) (P=0.003). In addition, the mean epithelization score of the study group (3.4 +/- 0.52) was significantly higher than the control group (2.1 +/- 0.57) (P=0.001). mRNA of TGF8, FGF2, VEGF, and p53 genes drastically increased phenytoin treated group. High FGF2 protein expression levels were determined from phenytoin use compared to the control group. CONCLUSION: Molecular studies suggest that phenytoin may increase the healing process of Gastric sleeve following SG in rats and may become a new agent for the prevention of human gastric leaks.
  • Küçük Resim
    Öğe
    Sentinel lymph node dissection in colorectal cancers: A single-center, prospective study
    (2019) Iflazoglu, Nidal; Eren Erdogan, Kivilcim; Duran, Ali; Parsak, Cem Kaan; Doran, Figen
    Aim: In this study, we aimed to investigate the feasibility of ex vivosentinel lymph node (SLN) mapping and to evaluate efficacy of this technique on staging in patients with colorectal cancer.Material and Methods: : This single-center, prospective study included a total of 35 patients (25 males, 10 females; mean age: 55 years; range, 35 to 85 years) who were diagnosed with Stage 2 colorectal cancer between May 2015 and August 2017. All patients underwent curative surgery and SLN dissection.Results: Tumor was located in rectum in 17, in sigmoid colon in six, in right colon in seven, and in left colon in five patients. Total abdominal colectomy was performed in six, left hemicolectomy in three, right hemicolectomy in six, low anterior resection in 14, anterior resection in two, and abdominoperineal resection in four patients. Of 17 patients with clinical Stage 2 rectal cancer, 15 underwent neoadjuvant chemoradiotherapy (CRT). All patients were histopathologically diagnosed with an adenocarcinoma. Median total number of SLNs dissected was 13 with 16.9 per patient. In two patients receiving neoadjuvant CRT due to rectal cancer, a pathological complete response was achieved. The failure rate of SLNs detection was statistically significantly higher for rectal tumors than the other tumors (p=0.041) and in the patients in whom ≤7 lymph nodes dissected (p=0.023). Conclusion: Our study results suggest that SLN mapping is a useful technique with high success ratesas well as further immunohistochemical examination of the SLNs doesn’t cause stage migration. However, the success rate is lower in rectal tumors than the other tumors and in the patients with ≤7 lymph nodes dissected.