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Öğe The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats(Taylor & Francis Ltd, 2015) Cakir, Murat; Polat, Alaadin; Tekin, Suat; Vardi, Nigar; Taslidere, Elif; Duran, Zeynep Rumeysa; Tanbek, KevserDexmedetomidine (dex) is a potent, highly selective and specific alpha 2-adrenoreceptor agonist. This experimental study was designed to investigate protective and therapeutic effect of two different doses of dex, on kidney damage induced by ischemia-reperfusion (I/R) in rats. Male Sprague - Dawley rats were divided into four groups, each including 10 animals: control group, ischemia-reperfusion (I/R) group; treated groups with 10 mu g/kg of dex and 100 mu g/kg of dex. After removing right kidney of the rats, the left kidney has performed ischemia during 40 min and reperfusion in the following 3 h. The histopathological findings, and also tissue superoxide dismutase (SOD) and catalase (CAT) enzyme activity, malondialdehyde (MDA), glutathione (GSH), serum blood urea nitrogen (BUN), creatinine (Cre) and tumor necrosis factor-alpha (TNF-alpha) levels were determined. In the I/R group, compared to the control group, levels of BUN, Cre and kidney tissue MDA have increased significantly, SOD, CAT enzyme activity and glutathione levels have decreased significantly. In the dex10 group, compared to the I/R group, levels of Cre and TNF-alpha have decreased significantly, while the SOD activity has increased significantly. In the dex100 group, compared to the I/R group, levels of BUN, Cre have decreased significantly, while the SOD activity has increased significantly. In the I/R group, there was also extensive tubular necrosis, glomerular damage in the histological evaluation. Dex ameliorated these histological damages in different amounts in two treatment groups. In this study, the protective effects of dex against renal I/R injury have been evaluated by two different amount of doses.Öğe Effects of ?- Glucan Liver Ischemia/Reperfusion Injury in Rats(Wiley-Blackwell, 2012) Aydogan, Mustafa Said; Yucel, Aytac; Erdogan, Mehmet Ali; Polat, Alaadin; Cetin, Asli; Ucar, Muharrem; Duran, Zeynep Rumeysa[Abstract Not Available]Öğe Effects of Melatonin and ?-Glucan Combination Hepatic Ischemia and Reperfusion in Rats(Wiley-Blackwell, 2012) Aydogan, Mustafa Said; Erdogan, Mehmet Ali; Polat, Alaadin; Yucel, Aytac; Ozgul, Ulku; Parlakpinar, Hakan; Duran, Zeynep Rumeysa[Abstract Not Available]Öğe The Protective Effect of Apocynin on Testicular Ischemia-Reperfusion Injury(Lippincott Williams & Wilkins, 2015) Ozbek, Ozkan; Altintas, Ramazan; Polat, Alaaddin; Vardi, Nigar; Parlakpinar, Hakan; Sagir, Mustafa; Duran, Zeynep RumeysaPurpose: We investigated the protective effect of the NADPH oxidase inhibitor apocynin on testicular damage induced by ischemia-reperfusion injury in rats. Materials and Methods: A total of 32 rats were randomly divided into 4 groups. Controls underwent left scrotal exploration only. The 3 groups with ischemia-reperfusion underwent 4-hour torsion followed by 1-hour detorsion. The ischemia-reperfusion only group underwent left testicular torsion and detorsion. The ischemia-reperfusion plus saline group underwent left testicular torsion, received 10 ml/kg saline intraperitoneally at minute 210 of ischemia and then underwent detorsion. The ischemia-reperfusion plus apocynin group underwent left testicular torsion, received 20 mg/kg apocynin intraperitoneally at minute 210 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. Results: In the ischemia-reperfusion only and the ischemia-reperfusion plus saline groups malondialdehyde, total oxidative capacity and the oxidative stress index were significantly higher. Superoxide dismutase, catalase, glutathione peroxidase and glutathione were significantly lower. Apocynin significantly decreased malondialdehyde, total oxidative capacity and the oxidative stress index, and significantly increased superoxide dismutase and catalase. There was a significantly increase in the number of giant, degenerated and desquamated cells in the ischemia-reperfusion group. Apocynin significantly improved these histological alterations. Conclusions: These histopathological and biochemical findings show the beneficial effects of apocynin on testicular ischemia-reperfusion injury.Öğe Protective Effects of Melatonin and ?-D-Glucan Against Liver Injury in Rats - a Comparative Study(Wroclaw Medical Univ, 2013) Aydogan, Mustafa Said; Erdogan, Mehmet Ali; Polat, Aladdin; Yucel, Aytac; Ozgul, Ulku; Parlakpinar, Hakan; Duran, Zeynep RumeysaObjectives. The aim of this study was to investigate the possible protective effects of melatonin and beta-D-glucan against ischemia-reperfusion (IR) injury in rats. Materials and Methods. Forty rats were randomly divided into 5 groups, each consisting of 8 animals, as follows. Sham group [S], IR group [C], IR + beta-Glucan group [beta], IR + melatonin group [MLT], IR + melatonin + beta-Glucan group [MLT + beta]. The rats in the C, beta, MLT and MLT + beta groups were subjected to IR for 60 min each. Melatonin (10 mg.kg(-1)) was intraperitoneally injected for a single dose 30 min before IR. beta-Glucan (50 mg.kg(-1).day(-1)) was orally administered for 10 days to rats. All of the rats were killed on day 11, and histological changes in the liver and tissue levels of oxidants and antioxidants were evaluated. Results. Malondialdehyde [MDA] level were significantly higher in the C group compared to the S group (p = 0.007). MDA level were significantly higher in the beta group compared to the MLT and MLT + beta groups (p = 0.007). Tissue antioxidant markers (superoxide dismut ase [SOD], glutathione-peroxidase [GPx], and catalase [CAT]) were significantly lower in the C group than the S group (p < 0.05). SOD levels were simply not significant in the beta group compared to the MLT and MLT + beta groups. CAT and GPx activities were significantly higher in the beta group compared to the MLT and MLT + beta groups (p = 0.004). The histological damage ameliorated in beta, MLT and MLT + beta groups compared to C group. Conclusion. Our results suggest that melatonin and beta-glucan combination pretreatment suppressed oxidative stress and increased antioxidant levels in an experimental rat model of liver IR injury
