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Öğe Autonomic nervous system function in childhood migraine(Blackwell Science Asia, 1999) Yakinci, C; Mungen, B; Er, H; Durmaz, Y; Karabiber, HBackground: Although the pathogenesis of migraine is controversial, autonomic nervous system (ANS) dysfunction has been reported in patients with adult migraine in recent years. The present study was planned to investigate ANS function in childhood migraine. Methods: The migraine and control groups consisted of 25 migraineur and 30 healthy children, respectively. Orthostatic test, sustained handgrip, Valsalva ratio, 30/15 ratio and heart rate responses to deep breathing were used as non-invasive ANS function tests in both groups. Results: In the orthostatic test, systolic (SBP) and diastolic blood pressures (DBP) were higher in the upright than the supine position in the migraine group, but were higher in the supine than upright position in the control group. In the sustained handgrip test, the mean difference in SEP was higher in the migraine than the control group (P = 0.0278), but there was no significant difference in DBP between migraine and control groups (P = 0.107). The Valsalva ratio was higher in the migraine than the control group (P = 0.0002), as was the 30/15 ratio (P = 0.0108). Heart rate responses to deep breathing were not different between the migraine and control groups (P = 0.749). Conclusions: Our results demonstrate ANS dysfunction, with hyperactivity of both the sympathetic and parasympathetic nervous system, in children with migraine.Öğe Autonomic nervous system functions in children with nocturnal enuresis(Elsevier Science Bv, 1997) Yakinci, C; Mungen, B; Durmaz, Y; Balbay, D; Karabiber, HNocturnal enuresis is involuntary urination during night sleep, The pathogenesis of nocturnal enuresis is controversial. Developmental delay, genetic factors, stress and psychological factors, and sleep abnormalities are considered to be the etiologic factors. Various urodynamic studies showed bladder hyperactivity in enuretic children. Since the cause of vesical hyperactivity is not clear, we investigated the possible role of autonomic nervous system dysfunction in these children. The study groups consisted of 41 enuretic (25 boys and 16 girls) and 30 healthy children (18 boys and 12 girls). Four non-invasive autonomic nervous system function tests (orthostatic test, Valsalva ratio, 30:15 ratio, heart rate responses to deep breathing) were carried out in both groups. The differences between the enuretic and control groups were statistically significant in the Valsalva and 30:15 ratios (P < 0.0005 and P < 0.005, respectively). The results of these two tests demonstrated parasympathetic nervous system hyperactivity. No abnormality of the sympathetic nervous system was found. We suggest that the parasympathetic nervous system hyperactivity shown in our study may be a cause of vesical hyperactivity in enuretic children. (C) 1997 Elsevier Science B.V.Öğe Cavernous hemangioma in a child presenting with hemichorea(B C Decker Inc, 2001) Yakinci, C; Durmaz, Y; Korkut, M; Aladag, A; Önal, C; Aydinli, MThe case of a 9-year-old boy with hemichorea due to cavernous hemangioma in the left caudate nucleus is presented. To our knowledge, only two children have been reported with hemichorea associated with cavernous hemangioma. Hemichorea in our patient responded to pimozide, a neuroleptic that blocks central nervous system dopaminergic receptors.Öğe Head circumference measurement of urban children aged between 6 and 12 in Malatya, Turkey(Elsevier Science Bv, 2001) Karabiber, H; Durmaz, Y; Yakinci, C; Kutlu, O; Gumusalan, Y; Yologlu, S; Yalaz, KHead circumference (HQ is one of the most significant findings in physical examination, especially in the evaluation of the development and early diagnosis of neurological disorders in children. In the standard charts for developmental evaluation of Turkish children, there is no HC reference values for children over 6 years of age. Since the HC standards show differences among races and generations, many researchers have obtained normal values for their own populations, and recommend periodic reevaluation of these standards. In this study, the HC of 1826 healthy children (945 male, 881 female) aged between 6 and 12 years was measured in order to establish the Turkish standards. The sample represented various socioeconomic levels in the city of Malatya, Turkey. The study was conducted in ten schools and measurements were done twice by a pediatrician and the mean was recorded. Charts and graphs for boys and girls were prepared separately. Results were compared to the values of other populations. HC values of Turkish children were similar to that of Irish children. The data obtained in this study may replace the Nelhaus criteria to be used in clinics. However, a more widespread study should be carried out by including children from different regions of Turkey. (C) 2001 Elsevier Science B.V. All rights reserved.Öğe Hypomelanosis of Ito with trisomy 13 mosaicism [46, XY, der (13;13) (q10;q10),+13/46,XY](Turkish J Pediatrics, 2002) Yakinci, C; Kutlu, NO; Alp, MN; Senol, M; Durmaz, Y; Budak, TThe term hypomelanosis of Ito (HI) has been used as a diagnosis for individuals with swirly hypopigmentation or depigmentation distributed along the lines of Blaschko. HI should be appropriately evaluated for a possible association with chromosomal or genetic mosaicism or chimerism. We report a six-month-old severely motor and mental retarded boy with these typical cutaneous lesions associated with extracutaneous features, including facial dysmorphism, polydactyly, and inguinal. hernia. The cytogenetic examination of lymphocytes kdemonstrated a mosaicism of 46, XY, der (13;13) (q10;q10), +13/46, XY. This is the first case reported in the literature showing an association between phylloid pigmentary pattern of hypomelanosis of Ito and trisomy 13 mosaicism.Öğe Intranasal midazolam for prolonged convulsive seizures(Elsevier Science Bv, 2000) Kutlu, NO; Yakinci, C; Dogrul, M; Durmaz, YIn order to determine the efficiency of intranasal midazolam in prolonged convulsive episodes, we conducted a prospective study in children with various types of seizures. Nine patients (six buys, three girls; age range 6 months to 9 years) with prolonged convulsions lasting more than 10 min were treated with intranasal midazolam, 0.3 mg/kg. The success rate was 100% with only one case requiring a second dose. Estimated duration of seizures was 12-30 min (mean 18.6) while mean time elapsed until cessation of seizures was 139.6 s (range 60-480). No significant adverse effects were noted except fur one patient who had seizures secondary to serious CNS infection and respiratory depression after intranasal midazolam. (C) 2000 Elsevier Science B.V. All rights reserved.Öğe Midazolam in treatment of various types of seizures in children(Elsevier Science Bv, 1997) Yakinci, C; Müngen, B; Sahin, S; Karabiber, H; Durmaz, YMidazolam is a recently developed water-soluble benzodiazepine that shares anxiolytic, muscle relaxant, hypnotic and anticonvulsant actions with other members of this class. There are limited studies that midazolam can be used successfully to treat seizures in adults and children. In this study, 0.2 mg/kg intramuscular (IM) midazolam was administered to 11 children (eight boys and three girls), aged 3 days to 4 years (mean age 1.8 +/- 1.4 years), with seizures of various types. In all but one child, seizures stopped in 15 s-5 min after injection. No side effects were observed. These results suggest that IM administration of midazolam may be useful in a variety of seizures during childhood, especially in case of intravenous (IV) line problem. (C) 1997 Elsevier Science B.V.Öğe Normative values of craniofacial measurements in idiopathic benign macrocephalic children(Alliance Communications Group Division Allen Press, 2001) Evereklioglu, C; Yakinci, C; Er, H; Doganay, S; Durmaz, YObjective: To determine normal standard values at each age for head circumference; inner canthal distance; outer canthal distance; near interpupillary distance; distant Cfar] interpupillary distance; canthal index; and circumference-interorbital index specific for the age, sex, and race in 7- to 16-year-old idiopathic benign macrocephalic male and female children, Methods: The measurements of head circumference were obtained in 8736 children (4591 boys and 4145 girls) in the city center of Malatya. From these, macrocephalic children (boys = 103, girls = 93) were chosen and invited to our clinic for detailed examination. Mean values for each parameter were obtained at each age from 7 to 16 years. Results: The mean age for male and female children were 11.87 +/- 2.87 and 11.72 +/- 2.75 years, respectively. The overall mean values for head circumference, inner canthal distance, outer canthal distance, near interpupillary distance, distant interpupillary distance, canthal index and circumference-interorbital index in boys were found to be 57.43 +/- 1.46 cm, 31.90 +/- 2.41 mm, 89.29 +/- 4.34 mm, 58.79 +/- 2.97 mm, 62.10 +/- 3.23 mm, 35.73 +/- 2.24, and 5.56 +/- 0.44, respectively. In girls, these values were 56.57 +/- 1.24 cm, 31.45 +/- 2.65 mm, 87.71 +/- 4.11 mm, 58.16 +/- 3.46 mm, 61.26 +/- 3.66 mm, 35.84 +/- 2.31, and 5.56 +/- 0.43, respectively, Conclusion: Normal values of craniofacial measurements for idiopathic benign macrocephalic healthy children are useful in early identification of some craniofacial syndromes, congenital or posttraumatic telecanthus, epicanthus, and hypo-hypertelorism and of planning surgical intervention, We suggest that the comparison of craniofacial dimensions of macrocephalic healthy children must be performed with normal standards specific for age as well as sex and race.Öğe Prevalence of epilepsy in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2001) Karabiber, H; Yakinci, C; Durmaz, Y; Kutlu, O; Soylu, H[Abstract Not Available]Öğe Prevalence of epilepsy in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2001) Karabiber, H; Yakinci, C; Durmaz, Y; Kutlu, O; Soylu, H[Abstract Not Available]Öğe Prevalence of febrile convulsion in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2000) Yakinci, C; Kutlu, NO; Durmaz, Y; Karabiber, H; Egri, M[Abstract Not Available]Öğe Serum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepine(Elsevier Science Bv, 2004) Karabiber, H; Yakinci, C; Durmaz, Y; Temel, I; Mehmet, NIn experimental epilepsy studies, nitric oxide was found to act as both proconvulsant and anticonvulsant. The objective. of this study was to investigate the effects of valproic acid and carbamazepine on serum levels of nitrite and nitrate, which are the metabolites of nitric oxide. To achieve this goal, serum nitrite and nitrate levels were determined in active epileptic 34 children using valproic acid and 23 children using carbamazepine and in non-active epileptic 38 children (control group) not using any antiepileptic drug. In the valproic acid group serum nitrite and nitrate levels were 2.66 +/- 2.11 mumol/l and 69.35 +/- 23.20 mumol/l, 1.89 +/- 1.01 mumol/l and 49.39 +/- 10.61 mumol/l in the carbamazepine group, and 1.22 +/- 0.55 mumol/l, 29.53 +/- 10.05 mumol in the control group, respectively. Nitrite and nitrate levels were significantly high in both valproic acid and carbamazepine groups compared to the control group (P < 0.01). When valproic acid and carbamazepine groups were compared to each other, level of nitrate was found statistically higher in the valproic acid group in relation to the carbamazepine group (P < 0.01), however, there was no statistically significant difference in the levels of nitrite (P > 0.05). No relation could be found between serum drug levels and nitrite and nitrate levels. According to these results, it can be suggested that valproic acid and carbamazepine might have antiepileptic effects through nitric oxide. (C) 2003 Elsevier B.V. All fights reserved.Öğe Serum vitamin A and beta-carotene Levels in children with giardiasis before and after treatment(Oxford Univ Press, 1998) Yakinci, C; Küçükbay, FZ; Durmaz, Y; Küçükbay, H; Rafig, M[Abstract Not Available]
