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Öğe ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats(Pergamon-Elsevier Science Ltd, 2017) Cakir, Murat; Duzova, Halil; Tekin, Suat; Taslidere, Elif; Kaya, Gul Busra; Cigremis, Yilmaz; Ozgocer, TubaAim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA). Main methods: OKA (200 ng/10 mu l) was administered bilateral intracerebroventricularly as a single injection. Key findings: OKA-treated rats showed significant impairments of spatial memory in Morris Water Maze Test. OKA-induced memory-impaired rats showed increased numbers of degenerated neurons and Caspase-3, tau phosphorylated ser396, beta-amyloid positive cells in the hippocampus and cerebral cortex. Furthermore, OKA-treated rats exhibited significantly increased MDA, TNF-alpha levels, and decreased SOD, GSH-PX enzyme activates and GSH levels of the tissues. ACA administration ameliorated OKA-induced memory impairment in rats. The ACA treatment also increased SOD and GSH-PX enzyme activation and GSH levels, and conversely decreased the levels of MDA, TNF-alpha. It was found that the numbers of the degenerated neurons and Caspase-3 positive cells of cortex and hippocampus regions were significantly reduced. Significance: ACA administration attenuates the oxidative stress and neuroinflammation of OKA-induced neurodegeneration; and ameliorates the cognitive decline and neurodegeneration. (C) 2017 Elsevier Inc. All rights reserved.Öğe The acute effects of single football match on whole blood viscosity and hematological variables in female soccer players(Scientific Publishers India, 2016) Duzova, Halil; Karakoc, Y.; Gullu, E.; Gullu, A.; Koksal, B.; Esen, B.In this study, we aimed to investigate the acute effects of single 90-minute football match on whole blood viscosity and hematological variables in amateur female soccer players. Ten subjects were selected from the female footballers of an amateur regional football club in Turkey, at the last week of football season. Prior to last seasonal football match venous blood samples were drawn. After 90 minute football match, the researchers stopped the match timely and blood samples were redrawn from subjects. From the samples, pre- and post-match hematological parameters, lactate level, blood viscosity, plasma Na+ and K+ levels were determined. The results showed that mean corpuscular volume (MCV), Na+ and K+ levels were all decreased significantly whereas numbers of white blood cell (WBC) and platelet (PLT) were both increased after the match. We didn't find statistically significant difference in whole blood viscosity after the match. Blood lactate levels were also significantly increased after the match. Our results showed that blood viscosity of female footballers tends to increase by this type of training due to decrease in body waters and increase in WBC and PLT numbers of amateur female footballers. Increase in blood lactate levels is remarkable and may have adverse effect on blood viscosity of these subjects because some protective mechanisms might not have adequately developed with regular training throughout the season.Öğe Effect of ACA on Ischemia/Reperfusion Injury in Rats (A Histological Study)(Wiley, 2018) Cakir, Murat; Taslidere, Asli; Tekin, Suat; Duzova, Halil[Abstract Not Available]Öğe Effect of ACA on Ischemia/Reperfusion Injury in Rats (A Histological Study)(Acta physıologıca, 2018) Çakır, Murat; Taşlıdere, Aslı; Tekin, Suat; Duzova, HalilÖğe The Effect of Apricot Added Sports Drink on Cardiac Mitochondrial Dysfunction in High Intensity Exercising Rats(Wiley, 2023) Ozer, Muhammed Yusuf; Duzova, Halil; Gul, Mehmet; Arslan, Ozge; Elmas, Furkan; Koc, Ahmet; Durmaz, Gokhan[Abstract Not Available]Öğe The effect of exercise induced weight-loss on myokines and adipokines in overweight sedentary females: steps-aerobics vs. jogging-walking exercises(Edizioni Minerva Medica, 2018) Duzova, Halil; Gullu, Esin; Cicek, Guner; Koksal, Burcu K.; Kayhaayhan, Basak; Gullu, Abdullah; Sahin, IbrahimBACKGROUND: The objectives of this study were to verify effects of step-aerobic exercise (SAE) and jogging-walking exercise (JWE) program on myokines and adipokines levels in overweight sedentary females. METHODS: Volunteer subjects (N.=25) were assigned to two exercise groups: steps aerobics and jogging-walking. The exercise program given to them was for five days a week and for twelve weeks period. Serum samples were collected from venous blood before and immediately after Cardio-Respiratory Fitness Test (CRF) by Bruce protocol and stored at -80 degrees C until they were assayed before 12 weeks exercise program. After 12-weeks training program this procedure was repeated. Serum TNF-alpha, IL-6, IL-15, IL-17, IL-18, leptin, resistin and adiponectin levels were assayed by ELISA. RESULTS: Leptin and IL-15 levels were increased whereas resistin levels were decreased after CRF Test in JWE training group following 12-weeks exercise program. TNF-alpha, IL-15 and IL-18 levels were higher and leptin levels were lower in SAE group than JWE group after 12-weeks exercise period. However, both SAE and JWE did not lead to significant change in serum levels of IL-17, IL-6 and adiponectin levels. CONCLUSIONS: This study has added to existing knowledge that both SAE and JWE may cause weight loss especially in fat mass. But, the effect of SAE and JWE on myokines and adipokines levels may be the different. Further studies are needed to find out clinical importance of these findings.Öğe The effect of hypericum perforatum on kidney ischemia/reperfusion damage(Taylor & Francis Ltd, 2017) Cakir, Murat; Duzova, Halil; Baysal, Isil; Gul, Cemile Ceren; Kuscu, Gulbahar; Kutluk, Fatma; Cakin, HilalIt has been revealed in recent studies that Hypericum Perforatum (HP) is influential on cancer, inflammatory diseases, bacterial and viral diseases, and has neuroprotective and antioxidant properties. In this study, we investigated the effect of HP, which is known to have antioxidant and anti-inflammatory effects, on kidney I/R damage. Male Sprague-Dawley rats were divided into three groups, and each of the groups had eight rats: The Control Group; the Ischemia/Reperfusion (I/R) Group; and the IR+HP Group which was treated with 50mg/kg of HP. The right kidneys of the rats were removed, and the left kidney developed ischemia during the 45th min, and reperfusion occurred in the following 3rd h. The histopathological findings and also the level of Malondialdehyde (MDA), Glutathione (GSH) and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) enzyme activations in the renal tissues were measured. Blood Urea Nitrogen (BUN), Creatinin (Cre) from serum samples were determined. The levels of BUN, Cre, and kidney tissue MDA increased at a significant level, and the SOD, CAT, and GSH-PX enzyme activity decreased at a significant level in the I/R group, compared with the Control Group (p < 0.05). In the I/R vertical bar HP group, the levels of MDA decreased at a significant level compared to the I/R group, while the SOD, CAT, and GSH-PX activity increased (p < 0.05). In histopathological examinations, it was observed that the tubular dilatation and epithelial desquamation regressed in the IR vertical bar HP Group when compared with the I/R Group. It has been shown with the histological and biochemical results in this study that HP is protective against acute renal I/R.Öğe Effect of Salusin-? and Salusin-? on Heart Damage Following the Renal Ischemia/Reperfusion(Wiley-Blackwell, 2016) Cakir, Murat; Taslidere, Asli; Duzova, Halil; Orhan, Guler[Abstract Not Available]Öğe Effect of Salusin-? and Salusin-? on Liver Damage Following the Renal Ischemia/Reperfusion(Wiley, 2017) Cakir, Murat; Taslidere, Asli; Duzova, Halil; Orhan, Guler[Abstract Not Available]Öğe Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats(Journal Sports Science & Medicine, 2009) Duzova, Halil; Karakoc, Yunus; Emre, Memet Hanifi; Dogan, Zumrut Yilmaz; Kilinc, EvrenIn this study, we aimed to compare the effects of a single bout of acute moderate and strenuous running exercise on the production of interleukin-17 (IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and inflammatory response of skeletal muscles in regularly trained rats. Eight week old rats were trained by treadmill running 5 days per week for 13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two days after the last training session, the animals were subjected to a single bout of moderate or strenuous exercise and serum samples were analyzed for IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius muscle were determined. IL-17 level significantly increased in strenuous exercise group when compared to that of sedentary controls (p < 0.01), On the other hand, only in the moderate exercise group, there was a negative correlation between IL-6 and IL-17 levels (r = 0.857 and p = 0.014). In conclusion, acute single bout of strenuous exercise increased IL-17 production in trained rats and, this cytokine may be involved in inflammatory process of skeletal muscles.Öğe Effects of Hypericum perforatum on Renal Ischemia-Reperfusion Injury in the Rat(Wiley-Blackwell, 2016) Cakir, Murat; Duzova, Halil[Abstract Not Available]Öğe Effects of noopept on cognitive functions and pubertal process in rats with diabetes(Pergamon-Elsevier Science Ltd, 2019) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Cakan, Pinar; Kaya, Gul Busra; Bag, Harika Gozde Gozukara; Durhan, MerveAim: Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties. We tried to determine the effects of noopept on pubertal diabetes. Main method: The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats. The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept. T1DM model was induced by streptozotocin on postnatal 28th day. 0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days. Blood glucose and body weight measurements, puberty follow-up and MWM tests were performed. Hippocampus, hypothalamus and testis were evaluated histologically. Hypothalamic GnRH and kisspeptin were studied immunohistochemically. Serum LH, FSH and insulin, hippocampal homogenate NGF and BDNF levels were determined by ELISA. Key findings: Delayed puberty was normalized by noopept (p < 0.05). Blood glucose levels were lower in noopept-administered diabetic groups (p < 0.05). Noopept decreased HOMA-IR in insulin administered diabetic group (p < 0.05). Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05). GnRH immunoreactivity in Diabetes + Noopept group was increased when compared to insulin + noopept group (p = 0.018). There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05). Significance: Noopept may have positive effect in treatment of pubertal diabetes.Öğe Effects of Noopept on Eye and Kidney in Prepubertal Rats with Streptozotocin-induced Diabetes(Wiley, 2018) Gurbuz, Perihan; Duzova, Halil; Gul, Cemile Ceren; Taslidere, Asli Cetin[Abstract Not Available]Öğe Effects of Noopept on Hippocampal NGF and BDNF Levels and Cognitive Functions of Prepubertal Rats with Streptozotocin-Induced Diabetes(Karger, 2018) Gurbuz, Perihan; Duzova, Halil; Kaya, Gul Busra; Cakan, Pinar; Durhan, Merve[Abstract Not Available]Öğe Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats(Taylor & Francis Ltd, 2023) Gurbuz, Perihan; Duzova, Halil; Taslidere, Asli Cetin; Gul, Cemile CerenDiabetes mellitus (DM) is a chronic disease at all ages including childhood and puberty. Failure to treat DM can cause retinopathy, nephropathy and neuropathy. Endocrine and metabolic changes during the pubertal period complicate management of DM. Noopept is a cognitive enhancer that exhibits antidiabetic properties. We investigated the effect of noopept on the histopathology of the cornea, retina, kidney and pancreas in pubertal diabetic rats. We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N). DM was induced by streptozotocin in the DC, D + N, D + I and D + I + N groups. Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days. On day 18 of the experiment, animals were sacrificed and eyes, kidneys and pancreata were excised for histological investigation. Renal tubule diameter and corneal and retinal thickness were increased significantly in DC groups compared to the control group. The D + I, D + N and D + I + N groups exhibited fewer DM induced pathological changes than the DC group. The D + I + N group exhibited no significant differences in renal tubule diameter and corneal and retinal thickness compared to the DC group. Our findings suggest that noopept is protective against DM end organ complications in streptozotocin induced diabetic pubertal rats.Öğe Effects of Noopept on Oxidative Stress Related Parameters in the Streptozotocin-Induced Diabetes Model(Wiley, 2022) Gurbuz, Perihan; Duzova, Halil; Kayhan, Basak; Cig, Bilal; Naziroglu, Mustafa; Akatli, Ayse Nur[Abstract Not Available]Öğe Effects of Noopept on Pubertal Process in Streptozosin-induced Diabetic Prepubertal Rats(Wiley, 2017) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Kaya, Gul Busra; Bag, Harika Gozukara; Taslidere, Asli Cetin; Gul, Ceren[Abstract Not Available]Öğe Effects of Salusin-? on Various Cytokines and Lipid Peroxidations in Rats Subjected to an Expermental Renal Ischemia/Reperfusion of Rats(Wiley, 2015) Cakir, Murat; Duzova, Halil; Orhan, Guler; Cetin, Asli; Ozyalin, Fatma[Abstract Not Available]Öğe Effects of Severe Aerobic Exercise on Endoplasmic Reticulum Stress and Cellular Damage(Wiley, 2022) Korkmaz, Kubranur; Duzova, Halil; Durmus, Kubra; Koc, Ahmet; Taslidere, Asli Cetin[Abstract Not Available]Öğe Investigation of the Neuroprotective Effect of N-(p-amylcinnamoyl) Anthranilic Acid on Hippocampal Endoplasmic Reticulum Stress in WAG/Rij Rats with Absence Epilepsy(Wiley, 2022) Kaya, Gul Busra; Duzova, Halil; Kaya, Mehmet; Dundar, Muhammed; Koc, Ahmet[Abstract Not Available]
