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    Determination of maternal serum pro-inflammatory cytokine changes in intrauterine growth restriction
    (Verduci Publisher, 2023) Kirici, P.; Cagiran, F. T.; Kali, Z.; Tanriverdi, E. F.; Mavral, N.; Ecin, S. M.
    OBJECTIVE: To evaluate ma-ternal serum inflammatory marker changes in intrauterine growth restriction (IUGR) preg-nancies.PATIENTS AND METHODS: 50 healthy preg-nant women and 50 patients diagnosed with IU-GR were enrolled. Maternal serum high sensi-tivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), tumor necrosis fac-tor-alpha (TNF-alpha), interleukin (IL)-6, and IL-10 levels were measured before delivery and neonatal outcomes were evaluated.RESULTS: Birth weight, Apgar scores, and cord blood gas pH were lower in the IUGR group (p<0.001, p<0.001, p<0.001 and p=0.006, respectively). While the levels of ESR, hsCRP, IL-6, and TNF-alpha were higher, the IL-10 level was found to be lower in the IUGR group (p<0.001, p=0.033, p<0.001, p=0.004 and p<0.001, re-spectively). As ESR, hsCRP, and IL-6 levels in-creased, birth weight, Apgar scores, and cord blood gas pH decreased (p<0.001, p<0.001, p<0.001, p<0.001, p=0.02, p=0.002, p=0.001, p=0.03, p<0.001, p<0.001, p<0.001 and p=0.02, respectively). As TNF-alpha level increased, only birth weight and Apgar score at the 1st minute decreased (p=0.006 and p=0.048, respective-ly). As IL-10 level decreased, birth weight, Ap-gar scores, and cord blood gas pH decreased (p<0.001 for all). IL-6 (>3.2 pg/ml) had a sensi-tivity of 100%, specificity of 100%, PPV of 100% and NPV of 100%.CONCLUSIONS: While birth weight, Apgar score and cord blood pH decreased in IUGR cas-es, ESR, hsCRP, IL-6 and TNF-alpha levels increased. Combined measurement of these markers can be used for the diagnosis of IUGR.