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Öğe Ankilozan spondilit’li erkek hastaların omurga deformitelerinin ve günlük yaşam kalitesinin değerlendirilmesi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Canbay, Özden; Köse, Evren; Öner, Zülal; Altay, Zuhal; Ekinci, NihatAmaç: Postür, vücudun her hareketinde eklemlerin aldığı pozisyonların birleşimidir. Çalışmamızın amacı; Ankilozan Spondilit’li (AS) hastalarda postür analizine bakılarak omurga deformitelerinin belirlenmesi ve bunların AS’li hastaların günlük yaşam aktiviteleri ve kalitesi üzerine nasıl bir etkide bulunduğunun araştırılmasıdır. Gereç ve Yöntem: Çalışmaya 30 AS’li ve 30 sağlıklı birey alındı. Tüm bireylere postür analizi, SF-36 yaşam kalitesi değerlendirme anketi ve Beck Depresyon ölçeği uygulandı. Kaslarda kısalık ve kas kuvveti değerlendirildi. Bulgular: Postür analizi değerlendirmesi sonucunda hasta bireylerin torakal kifoz artışı, lumbal lordozda azalma, yuvarlak omuz, genu valgum ve pes planus deformitelerinin anlamlı oranda arttığı gözlendi. Vücut kitle indeksi ortalamaları ile postür analizi sonuçlarından servikal lordozda artış, düşük omuz ve genu varum açısından anlamlı bir fark bulunmadı. Belirli kas gruplarında ise kas kuvvetinde azalma ve kas kısalığı tespit edildi. Ankilozan spondilit’li hastalarda yaşam kalitesinin postüre bağlı olarak olumsuz etkilendiği belirlendi. Sonuç: Ankilozan spondilit’li hastalarda postürün bozulduğu, kaslardaki kısalığın hareketleri sınırlandırdığı ve buna bağlı olarak ortaya çıkan kas zayıflamasından dolayı yaşam kalitesinin düştüğü düşünülmektedir. Ayrıca eğitim seviyesi düşük olan bireylerin, hastalık hakkında yeterli bilgiye sahip olmadığı ve gereken önemi göstermedikleri görülmektedir.Öğe Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study(Hindawi Ltd, 2012) Kose, Evren; Sapmaz, Hilal Irmak; Sarihan, Ediz; Vardi, Nigar; Turkoz, Yusuf; Ekinci, NihatThe effects of montelukast against methotrexate-induced liver damage were investigated. 35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx). At the end of the experiment, the liver tissues of rats were removed. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues. In addition, the liver tissues were examined histologically. MDA and MPO levels of Mtx group were significantly increased when compared to control group. In Mtx + ML group, these parameters were decreased as compared to Mtx group. Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes. The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls. ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present. It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.Öğe Effect of angiostatin on 1,2-dimethylhydrazine-induced colon cancer in mice(Sage Publications Inc, 2013) Ertekin, Tolga; Ekinci, Nihat; Karaca, Omur; Nisari, Mehtap; Canoz, Ozlem; Ulger, HarunAntiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. Human plasminogen-derived angiostatin K1-3 is one of the most potent antiangiogenic agents known currently. However, it is unclear whether angiostatin has got protective effects on colon cancer. So we investigated the protective effects of angiostatin on 1,2-dimethylhydrazine (DMH)-induced colon cancer in mice. Thirty Balb/C male mice, weighing 25-30g and 8 weeks of age, were used. Twenty of the mice were treated with DMH subcutaneously (20mg/kg) once a week for 12 weeks. Six mice died during the DMH injection and surviving mice were divided into two groups (7 mice in DMH and 7 mice in DMH+angiostatin groups). In the angiostatin group, 6 weeks after the last DMH injection the animals were first treated with angiostatin (20g/mouse) intraperitoneally and then subcutaneously every 48h (5g/mouse) throughout a period of 12 weeks. The animals were killed after 30 weeks for histopathological examination. When we look at the distribution of lesions in the colon, they mainly occurred in the distal colon. The incidence of mean colonic lesions in a tumor-bearing mouse was 9.85 +/- 4.91 in those treated with DMH and 8.71 +/- 3.49 in those treated with angiostatin. The incidence of colon tumors was not significantly affected by low dose of angiostatin, and we noticed that the number of lesions decreased by 12% in DMH+angiostatin group compared to the number of the lesions in DMH group, but this decrease was not statistically significant (p>0.05). The administration period of angiostatin corresponds to the precancerous period and the reduction in the number of lesions could be important for the protective function of angiostatin in DMH+angiostain group. We assume that therapeutic effects of angiostatin are related to its doses, route of administration, frequency and administration period. In addition, we believe that combination of high doses of angiostatin with radiation, gene therapy or chemotherapy might be successful in proper tumor model.Öğe Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus(W B Saunders Co Ltd, 2011) Soysal, Handan; Unur, Erdogan; Duzler, Ayhan; Karaca, Omur; Ekinci, NihatThis study was conducted on determining the effects of phenytoin on the skeletal system of the fetuses of 13 Wistar Albino rats. The female rats were divided into two groups after the vaginal smear test: the group 1 (control group) included 6 individuals, whereas the group 2 (phenytoin group) comprised 7 animals. A dose of 25 mg/kg/day phenytoin was administered intraperitoneally to pregnant rats on the 8th-10th days of pregnancy and fetuses were obtained by C-section on the 20th day. A number of 82 fetuses were observed by double staining technique. Their lengths and weights were measured, revealing the statistically significant differences between the two groups (p < 0.001). The lengths of the fetuses in the group 2 were determined as to be 14% shorter and the weights 13% lower compared to those in the group 1. Similarly, number of the fetuses obtained in one gestation decreased 9% in the group 2. Ossification of the skull bones in the fetuses of the group 2 was observed eminently to be deteriorated through using dissection microscope and inspection. Costal separation anomaly was observed in the 10 fetuses of the group 2. The separated-laterally located costal components were not attached to the costal arch. Shape malformations in the last two ribs and wide angularity, particularly in the last six ribs, were also determined. This study has documented that intraperitoneal usage of the pheytoin during pregnancy may cause to different skeletal malformations, even with lower doses, in rat fetuses. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.Öğe An Evaluation of Spinal Deformities and Quality of Life in Male Patients with Ankylosing Spondylitis(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Canbay, Özden; Köse, Evren; Öner, Zülal; Altay, Zühal; Ekinci, NihatObjective: Posture is a combination of the positions which is taken by the joints in every movement of the body. The aim of this study is to determine the spine deformities by posture analysis in patients with ankylosing spondylitis, and, additionally, to evaluate the effects of these deformities on daily life activities and patients’ quality of life. Material and Methods: Thirty patients with ankylosing spondylitis and thirty healthy subjects were included in the study. Posture analysis, through SF-36, and Beck Depression Inventory were applied to all individuals. Shortening of muscles and muscle strength were evaluated. Results: An increase in thoracic kyphosis, a decrease in lumbar lordosis, deformities of round shoulder, genu valgum and pes planus were significantly prominent in the AS group compared to the healthy group. In both groups, no significant differences were found between means of their body mass index, increased cervical lordosis, low shoulder, and genu varum. There was a decrease of muscle strength and an increase of shortening of muscle in certain muscle groups. It was determined that quality of life in AS patients was negatively affected by posture. Conclusion: The physiologic and psychological status of patients with ankylosing spondylitis affects their quality of life because of the abnormal posture and weakness of the muscles resulting from the limitation of movement. The patients did not have enough information on their disorders and did not take care of the importance of the disease.Öğe Metotreksat’ın Neden Olduğu Akut Böbrek Hasarına Karşı Montelukast’ın Etkileri(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Köse, Evren; Beytur, Ali; Vardı, Nigar; Türköz, Yusuf; Ekinci, Nihat; Ekincioğlu, ZülalMetotreksat’ın neden olduğu böbrek hasarına karşı montelukast’ın etkileri araştırıldı. Gereç-Yöntem: 35 adet Wistar albino dişi sıçan 5 gruba ayrıldı: Grup I: Kontrol (K); Grup II: Montelukast (ML); Grup III: Metotreksat (Mtx); Grup IV: Önce metotreksat sonra montelukast verilen grup (Mtx+ML); Grup V: Önce montelukast sonra metotreksat uygulanan grup (ML+Mtx) olacak şekilde ayarlandı. Son uygulamalardan 24 saat sonra hayvanlar sakrifiye edilerek böbrek dokuları ve kanları alındı. Böbrek dokuları hem histolojik incelemeler hem de MDA analizi için kullanıldı. Kandan elde edilen serumlarda ise BUN ve Cr seviyeleri değerlendirildi. Bulgular: Sadece metotreksat uygulanan grupta kontrol grubuna gore MDA, BUN ve Cr seviyelerinde anlamlı bir artış tespit edildi. Bunun yanı sıra metotreksat enjeksiyonundan sonra montelukast verilen grupta bu parametreler düşmüştü. Histolojik olarak sadece metotreksat verilen grupta belirgin tübül hasarı varken montelukastın her iki uygulaması ise bu hasarları geriletmişti. Sonuç: Metotreksat’ın neden olduğu deneysel böbrek hasarında, montelukast’ın bu hasarı azalttığı ortaya kondu.Öğe The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development(Medicine Science | International Medical Journal, 2016) Çuğlan, Songül; Ekinci, Nihat; Yıldız, Azibe; Doğan, Zümrüt; Sapmaz, Hilal Irmak; Vardı, Nigar; Özyalın, Fatma; Bakırcı, Sinan; Çay, Mahmut; Köse, Evren; Türköz, Yusuf; Özbağ, DavutThis study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically.Öğe The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development(2017) Cuglan, Songul; Ekinci, Nihat; Yıldız, Azibe; Doğan, Zümrüt; Sapmaz, Hilal Irmak; Vardı, Nigar; Özyalın, FatmaThis study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically
