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    Analysis of prognostic factors in Grade 3 endometrioid type endometrial carcinoma
    (Wiley, 2022) Sahin, Eda Adeviye; Toprak, Serhat; Sayal, Hasan Berkan; Ekinci, Tekin; Yilmaz, Ercan; Bakay, Kadir; Melekoglu, Rauf
    Objective To investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC). Methods This four-center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathologic, and survival data were collected. Kaplan-Meier method was used for survival analysis. Predictors of outcome were analyzed using Cox proportional hazards models. Results Median age at the time of diagnosis was 63 (range 39-87) years and median follow up was 37 (range 6-126) months. For the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) were 54.3% and 63.6%, respectively. The 5-year DFS rates for lymphovascular space invasion (LVSI) -positive and -negative patients were 41.6% and 88.3%, respectively (P < 0.001). The 5-year OS rates for LVSI-positive and -negative patients were 54.7% and 88.3%, respectively (P = 0.001). Positive LVSI status was identified as the independent prognostic factor for decreased DFS and OS (hazard ratio [HR] 5.5, 95% confidence interval [CI] 1.65-18.86; P = 0.006 versus HR 4.4, 95% CI 1.33-14.58; P = 0.013, respectively). Conclusion LVSI seems to be an independent prognostic factor for decreased DFS and OS in G3EEC patients.
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    Histopathologic effects of obstetric gel on the vaginal tissue: in vaginal trauma formed rat model
    (Taylor & Francis Ltd, 2024) Kaplan, Selcuk; Turk, Bilge Aydin; Elibol, Ebru; Ozbey, Guerkan; Ekinci, Tekin
    The present study aimed to investigate the histopathological effects of obstetric gel (OG) on vaginal tissue. In this study, 21 female Wistar albino rats were divided into three groups, comprising seven animals in each group. The first group (group 1) was the control group, the second group (group 2) was the physiological saline (PS) group, and the third group (group 3) was the OG group. In group 1, dilatation was performed using Hegar dilators from Hegar 5 to Hegar 10 without any vaginal application. In group 2, the vagina was washed with a PS-filled applicator. In group 3, the vagina was washed with an OG-filled applicator and Hegar dilators were used to achieve vaginal dilatation. In the group of OG-applied rats, there was an increase in mast cell infiltration, tissue epithelial thickness, and fibrillin-1 levels of the mucosa in the vaginal tissue. The present study is the first to investigate the histopathological effects of OG used for vaginal tissue dilatation in rats. OGs have no early effectiveness in preventing the damage caused by compression of the vaginal wall; however, OGs may have a protective effect against pelvic floor pathologies.