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  • Küçük Resim
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    The association of urotensin II with arterial stiffness and atherosclerosis in patients with autosomal dominant polycystic kidney disease
    (2019) Dolu, Suleyman; Coban, Melahat; Kilar Sozer, Yildiz; Erol, Bekir; Asilturk, Emre; Ellidag, Hamit Yasar
    Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Urotensin II (UT II) is the most potent vasoconstrictor peptide. The aim of the study was to investigate the relationship between UT II and arterial stiffness (AS) and atherosclerosis in ADPKD patients.Material and Methods: This cross-sectional study was conducted on 55 ADPKD patients with a mean age of 50 ± 14.4years. The presence of AS was determined with brachial-ankle pulse wave velocity (baPWV) and the presence of atherosclerosis was determined with carotid artery intima-media thickness (CA-IMT). Plasma UT II levels were determined by enzyme-linked immunosorbent assay.Results: Mean log10 UT II was 0.92±0.16 ng/mL. Mean baPWV and CA-IMT were 7.65±1.5 m/sec and 0.63±0.13 mm, respectively. Log10 UT II (p=0.009), baPWV (p 0.001) and CA-IMT (p=0.001) were high in patients compared to healthy individuals. There was an independent relationship between log10 UT II and creatinine (p=0.044) and spot urine protein-creatinine ratio (UPCR) (p=0.026) in multiple regression analysis. There was no relationship between log10 UT II and baPWV and CA-IMT.Conclusion: High plasma UT II levels were observed in ADPKD patients compared to healthy individuals. There was a relationship between UT II and kidney dysfunction and proteinuria. There was no relationship between UT II and AS and atherosclerosis.Keywords: Autosomal dominant polycystic kidney disease; arterial stiffness; atherosclerosis; urotensin ΙΙ.
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    Oxidant and antioxidant levels in patients diagnosed with acute coronary syndrome at the emergency department
    (2021) Tekkanat, Selma; Kozaci, Nalan; Avci, Mustafa; Selvi, Fatih; Yilmaz, Yavuz; Ellidag, Hamit Yasar
    Aim: The aim of this study is to compare high sensitive Troponin T (hs-TnT), total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), ischemia-modified albumin (IMA) levels and IMA/albumin ratios (IMAR) with the results of coronary angiography (CAG) in patients diagnosed with ACS at the emergency department. Materials and Methods: Over a period of nine months, patients that were diagnosed with ACS at the emergency department, admitted to the cardiac intensive care unit, subjected to percutaneous CAG and over the age of 18 were included in the study. Results: One hundred twenty five patients with suspected ACS and 52 healthy volunteers were included in the study. When the patients were evaluated with regards to the length of time between symptoms and arrival, TAC levels were found to decrease especially after the 6 th hour. There was no significant difference between TOC, OSI, IMA and IMAR values in this regard. Conclusion: In early-phase ACS, levels of TOC, OSI, IMA and IMAR rise from the 0th hour onwards. TAC levels gradually decrease after the early phase of ischemia. Therefore, oxidants and antioxidants can be used for early diagnosis of ischemia in ACS, as well as for estimating time of ischemia onset.