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    The effect of the use of herbal supply on daily life activities containing OTC (chondroitin sulfate
    (Bayrakol Medical Publisher, 2020) Sevimli, Resit; Guler, Ahmet; Canakci, Mehmet; Emeli, Adem; Turkmen, Ersen
    Aim: In this study, we aimed to compare pain, functional capacity, and quality of life of patients with knee osteoarthritis (OA), determine the factors affecting them, and investigate the effect of over-the-counter (OTC)-containing herbal supplementation on daily living activities in patients with knee OA. Materials and Methods: The study included 102 patients with the diagnosis of knee OA according to the American College of Rheumatology (ACR) criteria who were admitted to our orthopedics and traumatology outpatient clinic between March 2019 and September 2019. Demographic data were recorded. The visual analog scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), medical outcomes study short-form health survey (SF-36) were used. The Kellgren-Lawrence scale was used for radiological evaluation. Information about the patients was determined by the questionnaire method and the patients were evaluated according to recruitment/exclusion criteria. In the study group, 102 patients with knee OA were included. On the other hand, 100 patients received a placebo as a control group. After three months of OTC supplementation, daily life activities and functional tests were performed and data were collected. Both subjective and objective data were calculated, compared, and analyzed. Results: It was observed that more than 80% of the patients with OA included in the study relieved pain with our food supplement components. There was an improvment in functional abilities of the patients with chronic OA as compared to standard medical treatment, and the pain level decreased significantly with test scores and scales after supplementary foods. The secondary endpoint was also noticed. We noticed that our subjects actually lost an average of 1.5 kg over the course of the study. Discussion: OA is the most common form of arthritis and the leading cause of disability among middle-aged and elderly people. We can develop theoretical strategies for primary prevention of joint damage through the reduction of obesity and joint trauma in particular. Effective chondroprotective therapies will be most useful when applied to high-risk individuals before the emergence of symptomatic OA. Conclusion: We concluded that food supplementation that was used in our study seemed to be beneficial in patients with knee ailments such as OA. It was equally interesting to observe that the majority of patients lost weight while taking these supplements. Although the study was underpowered, it shed light on supplements containing glucosamine. We believe that further larger series studies in the near future can help us to obtain more objective findings.
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    Mid-term outcome of wide resection in musculoskeletal fibrosarcoma patients
    (2020) Sevimli, Resit; Emeli, Adem; Eriten, Semih
    The aim in this study, musculoskeletal system fibrosarcomas which are rare malignant soft tissue tumors that originate from fibroblasts, was to evaluate the mid-term outcome of patients that were diagnosed, treated and followed-up at our clinics. Included in the study were 12 patients treated for fibrosaecoma at our clinics between 2014 and 2017. The patients were evaluated in terms of age, location of tumor and time of resection, and were followed-up for mid-term recurrence. A wide resection was performed on all patients. No recurrence was found in all but one patient during follow-up. Musculoskeletal system fibrosarcomas are rare but represent high mortality and morbidity risks since the diagnosis is commonly delayed. The most frequently seen symptom is a painless mass reaching large dimensions. Early diagnosis plays a major role in prognosis, as is the case with other malignant tumors. In conclusion, we suggest that malignancy should be considered in the presence of giant, fixed and painful tumors, and a wide resection should be applied.
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    Our clinical results in the management of proximal humeral fractures
    (2020) Key, Sefa; Demir, Sukru; Emeli, Adem; Gurger, Murat; Sevimli, Reşit; Once, Gokhan
    Aim: The aim of this study was to evaluate the clinical, radiological and functional results of patients treated with different methods in our clinic for proximal humerus fracture. Material and Methods: A total of 106 patients with a diagnosis of proximal humerus fracture, who were scheduled for treatment, received management and followed up periodically after discharge were included. Patient files, X-RAY radiographs in the PACS system, surgical notes and outpatient epicrisis were used. Functional results were evaluated according to Constant shoulder score at the last visit.Results: The mean age of the patients was 53.6 years (17-94). The mean follow-up period was 11.3 months (6-40 months). 55 (51.9%) had Type II, 35 (33%) had Type III and 16 (15.1%) had Type IV proximal end humeral fractures. As a result of the evaluation performed at the last follow-up of the patients, Constant-Murley’s total score was 64.50 out of 100 (31-88). Score distribution according to Neer classification of patients; A Constant-Murley score median with a Neer Type II fracture was 74.00 (36-88), a Constant-Murley Score median with a Neer Type III fracture was 61.00 (31-78), and a Constant-Murley score median with a Neer Type IV fracture was 44.50 (33-70). Conclusion: When the fracture type and functional outcome of the patients were compared, functional outcome decreased as the fracture type increased. Young patients had better functional results than older patients.
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    Our clinical results in the management of proximal humeral fractures
    (2020) Key, Sefa; Demir, Şükrü; Emeli, Adem; Gürger, Murat; Sevimli, Reşit; Önce, Gökhan
    Abstract: Aim: The aim of this study was to evaluate the clinical, radiological and functional results of patients treated with different methods in our clinic for proximal humerus fracture. Material and Methods: A total of 106 patients with a diagnosis of proximal humerus fracture, who were scheduled for treatment, received management and followed up periodically after discharge were included. Patient files, X-RAY radiographs in the PACS system, surgical notes and outpatient epicrisis were used. Functional results were evaluated according to Constant shoulder score at the last visit. Results: The mean age of the patients was 53.6 years (17-94). The mean follow-up period was 11.3 months (6-40 months). 55 (51.9%) had Type II, 35 (33%) had Type III and 16 (15.1%) had Type IV proximal end humeral fractures. As a result of the evaluation performed at the last follow-up of the patients, Constant-Murley’s total score was 64.50 out of 100 (31-88). Score distribution according to Neer classification of patients; A Constant-Murley score median with a Neer Type II fracture was 74.00 (36-88), a Constant-Murley Score median with a Neer Type III fracture was 61.00 (31-78), and a Constant-Murley score median with a Neer Type IV fracture was 44.50 (33-70). Conclusion: When the fracture type and functional outcome of the patients were compared, functional outcome decreased as the fracture type increased. Young patients had better functional results than older patients.
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    Results of total hip artroplasty in our clinic
    (2019) Altunkilic, Tarik; Emeli, Adem; Sevimli, Reşit; Yilmaz, Erhan
    Aim: Patients undergone total hip replacement, performed in our clinic were retrospectively reviewed and discussed in the light of the available literature. The aim of this study was to determine our clinical results.Materials and Methods: The records of patients with total hip arthroplasty performed in our clinic between 2002 and 2008 were evaluated retrospectively. Laboratory values, Harris hip score and complications of these patients were examined.Results: The mean preoperative VAS of the 72 patients with a mean follow-up of 28.9 months was 81.6 preoperatively and the mean VAS was 35.7 in the last control. Harris hip score was 36.7 before the operation and 70.3 in the last control. According to Harris hip score of the patients in the preoperative period, 30 patients were evaluated as moderate and 42 patients as poor. In the postoperative period, 10 patients (13.8%) were excellent, 19 (26.3%) were very good, 30 (41.6%) were good, 6 (8.3%) were moderate, 7 (10%) were poorly rated according to Harris hip score. Biochemical laboratory values measured from venous blood taken at the time of arrival of patients, mean HsCRP 11.67±15.4 mg / l, insulin 14.87±29.53 IU / ml, glucose level 139.11±74.3 mg / dl, CK 426 9±12x8.9 mg / dl and CK-MB were determined as 41.1±46.8 mg / dl.Conclusion: As a result, we think that total hip arthroplasty is still an effective method in advanced hip arthrosis.Keywords: Arthroplasty; hip pain; loosening; complication.
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    SERUM GHRELIN LEVELS DURING FRACTURE HEALING AND IMMUNOHISTOCHEMICAL INVESTIGATION OF GHRELIN IN BONE TISSUE
    (Carbone Editore, 2014) Emeli, Adem; Inanmaz, Mustafa Erkan; Isik, Cengiz; Bentli, Recep; Karakurt, Locman; Belhan, Oktay
    Background: Ghrelin is a hormone with efficacy on increasing osteoblastic cell proliferation, differentiation, growth hormone release, and preventing apoptosis. The present study aimed to investigate whether ghrelin has a role in bone fracture healing process and presence in the bone tissue. Patients and methods: Blood samples of 10 patients, who underwent surgery for fracture repair, were obtained for 4 times in the manner that; before fracture stabilization (preoperative) and on the postoperative lst, 10th, and 60th days. Additionally, blood samples were obtained from 10 healthy subjects (control group). Ghrelin levels in serum samples were measured by enzyme-linked immunosorbent assay method and presence of ghrelin was imnzunohistochemically investigated in bone tissue samples. Results: Although no difference was found between the groups in terms of blood levels of ghrelin, it was observed that acylated ghrelin level was increased beginning from the postoperative 1st day as compared to the control group. Des-acylated ghrelin levels were also increased as compared to the controls, except for the postoperative 10th day. Ghrelin was not detected in bone tissues. Osseous union was observed in all patients of the fracture group. Conclusions: we thought that increased acylated and des-acylated ghrelin levels were contributed to fracture healing process by means of enhancing cell proliferation, preventing apoptosis, presenting anti-inflammatory and antimicrobial effect and increasing growth hormone release.