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    Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior
    (Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Sevler; Emir, Burcu Sirlier; Kilicaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Sehlikoglu, Seyma; Atmaca, Murad
    The role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.
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    Inflammatory markers and delirium in the intensive care unit
    (Mre Press, 2025) Yildiz, Sevler; Uslu, Muhammed Fuad; Emir, Burcu Sirlier; Kurt, Osman
    Background: Delirium is an important complication in patients admitted to intensive care unit (ICU). However, delirium prediction in patients admitted to the ICU is difficult. Considering the role of neuroinflammation in delirium, peripheral blood-based biomarkers of inflammation pressure could predict delirium. The aim of study was to retrospectively analyze ratios of neutrophil/high density lipoprotein (HDL) (NHR), lymphocyte/HDL (LHR), platelet/HDL (PHR), monocyte/HDL (MHR), as well as systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) in ICU patients diagnosed with delirium. Methods: The study included a total of 2141 patients with or without delirium. The risk factors for delirium development and the predictive power of individual laboratory parameters were evaluated with the Pearson chi-square test, Mann-Whitney U test, Spearman correlation test, logistic regression, and receiver operating characteristic analyses. Results: Length of ICU stay (p < 0.001), NHR (p = 0.035), LHR (p < 0.001), PHR (p = 0.047), MHR (p < 0.001), SIRI (p < 0.001), and SII (p < 0.001) were significantly higher in patients who developed delirium compared to those who did not. A significant negative correlation was found between the duration of delirium and SII (r = -0.260; p = 0.004). Older age, a history of psychiatric treatment, prolonged hospitalization, and high LHR, SIRI, and SII values were determined as risk factors for delirium (p < 0.05 for all). Conclusions: Elevated LHR, SIRI, and SII levels before ICU admission are associated with an increased risk of hyperactive delirium. If confirmed by prospective evidence, readily available biomarkers for inflammation could be used to evaluate the hyperactive delirium risk in ICUs.
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    Investigation of social support perceptions and mental health of postpartum women following the February 6, 2023 Turkey earthquake: a comparative study
    (Springer, 2025) Sehlikoglu, Seyma; Bekircan, Esra; Cicek, Sevil; Kurt, Osman; Yildiz, Sevler; Simsek, Yavuz; Emir, Burcu Sirlier
    Natural disasters, such as earthquakes, have significant psychological consequences, particularly for vulnerable populations like postpartum women. This study aimed to determine the relationship between perceived social support and mental health among postpartum women who had experienced an earthquake. In this comparative cross-sectional study, the case group (n = 62) consisted of women who were in their third trimester at the time of the earthquake and gave birth after the disaster, while the control group (n = 62) comprised women who were also in their third trimester during the earthquake and had given birth but were not residing in the earthquake-affected region and had no prior experience of an earthquake. The study did not include individuals with intellectual disabilities, illiteracy. Data were collected using the Sociodemographic data form, the Edinburgh Postnatal Depression Scale, the Multidimensional Scale of Perceived Social Support (MSPSS), the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), and the Post-Traumatic Growth Inventory (PTGI). The incidence rates of Posttraumatic Stress Disorder (40.3%) and Edinburgh Postnatal Depression Scale (43.5%) in postpartum women who experienced the earthquake were significantly higher than those in women who did not (Posttraumatic stress disorder: 6.5%, Edinburgh Postnatal Depression Scale: 16.1%) (p <.001). The mean total MSPSS score of postpartum women who experienced the earthquake (61.7 +/- 16.9) was significantly higher than that of those who did not (51.9 +/- 13.2) (p <.001). The mean PTGI total score in postpartum women who experienced the earthquake (69.0 +/- 19.2) was significantly higher than in the control group (57.3 +/- 20.0) (p <.001). In postpartum women who experienced the earthquake, there was a significant positive correlation between PTGI and MSPSS scores, and between PCL-5 and Edinburgh Postnatal Depression Scale scores (p <.001). Pregnant women who experienced the earthquake had significantly higher posttraumatic stress disorder and postpartum depression scores compared to those who did not. It was concluded that perceived social support may promote posttraumatic growth in women who have experienced a postpartum earthquake.
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    Investigation of social support perceptions and mental health of postpartum women following the February 6, 2023 Turkey earthquake: a comparative study (Vol 44, pg 13887, 2025)
    (Springer, 2025) Sehlikoglu, Seyma; Bekircan, Esra; Cicek, Sevil; Kurt, Osman; Yildiz, Sevler; Simsek, Yavuz; Emir, Burcu Sirlier
    [No abstract available]
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    Markers of inflammation in patients with generalized anxiety disorder
    (Cukurova Univ, Fac Medicine, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Tabara, Muhammed Fatih; Kurt, Osman; Sehlikoglu, Seyma; Ugur, Kerim
    Purpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lymphocyte, and platelet counts; systemic inflammatory calculated. contributing to both diagnosis and management.
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    Serum HMGB1 and Beclin 1 Levels in Patients with a Diagnosis of Schizophrenia
    (Turkiye Sinir Ve Ruh Sagligi Dernegi, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Ugur, Kerim; Kilic, Faruk
    Objective: It is known that inflammation plays a role in the etiopathogenesis of schizophrenia. In this study, we examined high mobility group box 1 protein (HMGB1) and Beclin 1 levels and their relationship with clinical variables in patients with schizophrenia. Method: Forty-three patients with schizophrenia and 43 healthy controls were included in this study. The patients were administered sociodemographic data form, the Positive Negative Symptoms Assessment Scale (PANSS) and the Clinical Global Impressions (CGI) scale. After the scales were filled, venous blood samples were taken from both the patient and control groups to measure serum HMGB1 and Beclin 1 levels. Serum samples obtained at the end of centrifugation were measured by Enzyme -Linked ImmunoSorbent Assay (ELISA) method. Results: The mean serum HMGB1 levels were significantly increased and the mean serum Beclin 1 levels were significantly decreased in the schizophrenia group compared to the control group. In addition, a negative correlation was found between HMGB1 and Beclin 1 levels. Conclusion: In conclusion, current research shows that HMGB1 is increased and Beclin 1 is decreased in patients with schizophrenia, and these findings may contribute to the role of autophagy in the pathogenesis of schizophrenia.
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    Technology Addiction and Social Connectedness in Psychiatric Illness: A Multicenter Study
    (Korean Neuropsychiatric Assoc, 2024) Kurt, Osman; Tabara, Muhammed Fatih; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Oktay, Meltem; Cansel, Neslihan
    Objective: Technology addiction is an increasingly important public health problem all over the world that negatively affects people's mental and physical health. In this study, we examined technology addiction and social connectedness levels of psychiatric patients who admitted to clinics in different geographical regions of Turkey. Methods: A total of 642 people with a diagnosis of psychiatric illness who applied to psychiatry clinics in & Idot;stanbul, Elazig, Malatya, Yozgat, Ad & imath;yaman, and Bingol provinces were included. Sociodemographic data form, Technology Addiction Scale (TAS), and Social Connectedness Scale (SCS) were applied to all participants. Results: The total score of the TAS in patients diagnosed with anxiety disorder and somatoform disorder was significantly higher than the other patient groups (p<0.001). Patients diagnosed with anxiety disorder showed a significant difference from other patient groups in terms of SCS score (p<0.001). Anxiety disorder was found to be the highest in TAS total score and sub-dimensions and the lowest in SCS score, while major depressive disorder was found to be the lowest in TAS total score and sub-dimensions and the highest in SCS score. The multiple linear regression analysis showed that the total score of the TAS was predicted by the SCS score (beta=-1.857, p<0.001) and the SCS score was predicted by age (beta=0.046, p=0.049) and the total score of the TAS (beta=-0.316, p<0.001). Conclusion: As a result of this study, we can say that psychiatric patients have a moderate level of technology addiction, these people have high levels of social connectedness, and psychiatric patients with technology addiction have a high level of social belonging.