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    Proteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantation
    (Bentham Science Publ Ltd, 2019) Coskun, Abdurrahman; Baykal, Ahmet Tarik; Oztug, Merve; Kazan, Dilek; Kaya, Ekrem; Emiroglu, Remzi; Yilmaz, Sezai
    Objective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period. Material/Methods: Samples were collected from the pre-transplant preservation mediums of 23 liver donors. For all donors, the cases involved Donation after Brain Death (DBD). 2D-PAGE and LCMSMS methodologies were used to detect the proteins and peptides from the preservation mediums. Results: A total of 198 proteins originating from the liver were detected. Conclusion: The data provide valuable insights into biomarkers that may be used to evaluate organ injury, functional status, and suitability for transplantation. Additionally, the findings could be valuable for the development of new strategies for effective preservation of solid organs prior to transplantation.
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    A rising necessity: Liver retransplantation: A single center experience
    (2021) Aktas, Hikmet; Emiroglu, Remzi
    Aim: Compared to primary liver transplantation, poor outcomes still remain an issue for liver retransplantation. Materials and Methods: We used registry data from our liver transplantation unit to perform a retrospective cohort study on liver retransplantations performed between January 2012 and October 2019. We considered patients who underwent retransplantation at least one month after primary transplantation as the late group. Patients who had retransplantation within the first month after the first transplantation were considered the early group. We analyzed features of patients, indications, donor types, characteristics of operations, and outcomes. Results: Among 782 patients who underwent liver transplantation, 29 patients underwent retransplantation in our center. Of these 29 patients, 19 patients were in the early group, while 10 patients were in the late group. The 3-year patient survival rates were 47.3% and 80% for the early and late groups, respectively. The overall 1-year survival rate for all retransplanted patients was 58.6%. Conclusion: Despite better results reported for liver retransplantation, there are poor outcomes compared with primary transplantation, especially in the early group. However, the necessity of retransplantation increases every passing year in spite of a shortage of donors. Thus, the justification for liver retransplantation remains controversial.