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Öğe Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications(Eur J Radiol, 2004) Alkan, Alpay; Kutlu, Ramazan; Koçak, Gülendam; Sığırcı, Ahmet; Emul, Murat; Doğan, Selda; Aslan, Mehmet; Saraç, Kaya; Yakıncı, Mehmet CengizPurpose: To investigate whether there are metabolite changes in basal ganglia of children with complete healing of rheumatic fever (RF), history of Syndenham chorea (SC) and obsessive compulsive-tic disorder (OCTD) developed after RF when compared with healthy controls and each other. Material and methods: A total of 49 children with history of RF and 31 healthy controls were included into the study. All patients and control group underwent a detailed neuropsychiatric evaluation. Children with the history of RF were classified into three groups as; group 1: with history of RF without neuropsychiatric complications (NCRF), group 2: only with history of SC (HSC), group 3: with HSC and OCTD (OCTD). After MR imaging, single voxel MR spectroscopy was performed in all subjects. Voxels (15 × 15 × 15 mm) were placed in basal ganglia. N-acetyl aspartate (NAA)/creatin (Cr), and choline (Cho)/Cr ratios were calculated. Results: OCTD were detected in 13 children with HSC. NAA/Cr ratio was found to be decreased in these children when compared with NCRF (n:29), HSC without OCTD (n:7) and control groups (n:31). No significant difference was found in metabolite ratios of children with HSC without OCTD when compared with NCRF and control groups. There were no significant differences in Cho/Cr ratio between patient and control groups. Conclusion: Although MR imaging findings was normal, MR spectroscopy findings (decreased NAA/Cr ratio) in our study support the neuronal loss in basal ganglia of children with OCTD and could indicate the development of permanent damage.Öğe Occupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findings(Magnetic Resonance Imaging, 2004) Alkan, Alpay; Kutlu, Ramazan; Tarık, Hallaç; Sığırcı, Ahmet; Emul, Murat; Pala, Nilgün; Altınok, Tayfun; Aslan, Mehmet; Saraç, Kaya; Özcan, AbdulcemalOur purpose was to investigate, by magnetic resonance (MR) spectroscopy, the metabolite changes in the brains of subjects in the shoemaking industry who had been chronically exposed to organic solvents. A total of 49 male subjects and 30 age-matched healthy volunteers underwent detailed neurological and psychiatric examinations. All subjects had long-echo [repetition time (TR) 2000 ms, echo time (TE) 136 ms] single-voxel MR spectroscopy. Voxels (15 15 15 mm3 ) were placed in the parietal white matter, thalamus, and basal ganglia. N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between the study subjects and the control group in NAA/Cr ratios obtained from thalamus, basal ganglia, and parietal white matter. Cho/Cr ratios in thalamus, basal ganglia, and parietal white matter were found to be significantly increased compared to controls. There was a positive correlation between basal ganglia Cho/Cr ratio and duration of exposure (r 0.63). MR spectroscopy should be performed to reveal metabolite changes and determine the degree of brain involvement in solvent-related industry workers.Öğe Sleepwalking in Multiple Sclerosis: A Case Report(Amer Psychiatric Publishing, Inc, 2010) Yalvac, H. Dilek; Emul, Murat; Karlidag, Rifat; Ozcan, Cemal; Unal, Suheyla[Abstract Not Available]
