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Öğe Association of fibrinogen and C-reactive protein with severity of preeclampsia(Elsevier Ireland Ltd, 2005) Üstün, Y; Engin-Üstün, Y; Kamaci, MObjective: The aim of this study was to determine the levels of plasma fibrinogen and C-reactive protein (CRP) in preeclampsia and their association with the severity of the disease. Study design: CRP and plasma levels of fibrinogen were investigated in 26 cases of normal pregnant women, 26 cases with mild preeclampsia and 26 cases with severe preeclampsia in the third trimester of pregnancy. Mean arterial pressure (MAP) was used as an indicator of the severity of the disease. Analysis of variance with the Kruskal-Wallis test was used when three groups were compared. For correlations, Spearman's rank correlation tests were used. A receiver operating characteristic curve was constructed to evaluate the sensitivity and specificity of CRP. Results: Plasma CRP and fibrinogen levels in mild and severe preeclampsia patients were markedly higher than that of normal third trimester pregnant women. There were significant correlations between MAP and CRP (r = 0.515, p = 0.0001) and MAP and fibrinogen parameters (r = 0.383, p = 6.005) in pregnancies complicated with preeclampsia. Conclusion: We found higher levels of fibrinogen and CRP and presence of good correlation between CRP and MAP in preeclampsia. (c) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Elevated nucleated red blood cell count(Sci Printers & Publ Inc, 2006) Üstün, Y; Engin-Üstün, Y; Kaya, E; Meydanli, MM; Kulak, NOBJECTIVE: To assess the prevalence and causes of elevated nucleated red blood cell (NRBC) count. STUDY DESIGN: We conducted a 1-year, population based surveillance study that included pregnant women and their infants from our medical center, which serves as a tertiary referral hospital. Outcome measures included NRBC count, gestational age, mode of delivery, birth weight, Apgar scores, cord blood gasses, rate of neonatal intensive care unit admission. Statistical analyses were performed with Mann-Whitney U-test, independent samples t test, chi(2) test, Fisher's exact test and Spearman's correlation test, as appropriate. RESULTS: NRBC count obtained from 423 women had a median of 4 (0-163). A cutoff point of 13.5 for predicting fetal acidosis had the highest combined sensitivity (77.8%) and specificity (84%). Three hundred forty-nine neonates had a NRBC count <= 13.5, whereas 73 had > 13.5. Logistic regression analysis revealed that preeclampsia (OR = 5.9, 95% CI = 2.8-12.3) remained the most prominent risk factor for elevated NRBC count. CONCLUSION: Elevated NRBC appears to be associated with preeclampsia.Öğe Maternal serum ceruloplasmin in preectampsia(Wiley, 2005) Engin-Üstün, Y; Üstün, Y; Kamaci, M; Sekeroglu, R[Abstract Not Available]
