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Cerebral metastasis of mucoepidermoid carcinoma as the first clinical presentation: Detailed immunohistochemical evaluation
(2008) Haltaş H.; Bozda? Z.; Engjn Aydin N.; Mizrak B.
Mucoepidermoid carcinoma (MEC) is known as a lowgrade malignant tumor. Lymph node and distant metastases are only seen in the high grade variant of MEC. The patient, 52-year-old male, had progressive vision loss, urinary incontinence and weakness at the left side at first physical examination. Computed tomography scan demonstrated 4×3×4 cm mass at parafalcian region in the brain and an additional 2×2 cm mass at right lung field. The resected mass in the brain was 4.5 cm in diameter, solid, necrotic, pale gray tissue with irregular borders. Microscopically the tumor was composed of squamoid, intermediate and glandular cells. Mucicarmine, PAS-Alcian blue, carcinoembryonic antigen-monoclonal (CEA-M), cytokeratin 7 and 18 staining revealed glandular cells to whereas cytokeratin 8 was focally expressed in squamoid cells. Cytokeratin 20 and c-erb-B2 were negative in all of the tumor cells. This case is a low grade MEC metastasis which emphasizes the malignant potential of these tumors.