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    Öğe
    Clinical trial to evaluate the outcome of canal wall up and canal wall down tympanomastoidectomy
    (2020) Cakmak Karaer, Isil; Ensari, Nuray
    Aim: The aim of this study was to evaluate the hearing outcomes of chronic suppurative otitis media surgery. Chronic suppurative otitis media (CSOM) surgery composed of two procedure; canal wall up mastoidectomy (CWU) and canal wall down mastoidectomy (CWD). Material and Methods:The study included 29 patients with CSOM diagnosis and patients a mean age of 37.02 ± 2.4 years (y). The demographic features (age, gender), clinical features and intraoperative findings of the patients were recorded. Patients’ hearing was evaluated with pure tone audiometry (PTA) at 0.5, 1, 2, 4 and 8 kHz and pre-postoperative air bone gap (ABG) difference. Pre- and post-operative air-bone gap (ABG) at 12 months after ossiculoplasty. There were 8 patients who underwent CWD and 21 patients who underwent CWU. Results: TWhen preoperative and postoperative ABG for the patients are compared, there were statistically significant differences identified at 0.5, 1, 2 and 8 kHz. However, there was no statistically significant difference identified at 4 kHz. Conclusion: Regardless to the surgical technique, statistically significant levels of hearing gain were provided at 0.5, 1, 2 and 8 kHz; however, there was no hearing gain at 4 kHz after the surgical procedure.
  • Küçük Resim Yok
    Öğe
    Oxidative stress in otosclerosis
    (Taylor & Francis Ltd, 2017) Baysal, Elif; Gulsen, Secaattin; Aytac, Ismail; Celenk, Fatih; Ensari, Nuray; Taysi, Seyithan; Binici, Habib
    Objectives: Otosclerosis is a disease involving abnormal bone turnover in the human otic capsule that results in hearing loss. Several hypotheses have been suggested for the etiopathogenesis of otosclerosis; however, its etiology remains unclear. Methods: This study evaluated the correlation between otosclerosis and levels of paraoxonase-1 (PON1), arylesterase, total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), total sulfhydryl (-SH) groups, lipid hydroperoxide, and ceruloplasmin in the serum of otosclerosis patients and healthy subjects with respect to oxidative stress. Results: In our study, TOS and OSI levels were higher in the otosclerosis patients than in the controls. The PON1 levels showed that oxidative stress was severe, and as a result, antioxidants were consumed and depleted. Discussion: When an imbalance between oxygen free radical production and antioxidative defense mechanisms occurs, reactive oxygen species levels may increase, which in turn may damage cells and tissues through the peroxidation of phospholipid membrane structures. The body initially responds with increased antioxidant production, but if the oxidative stress is severe, decreased antioxidant levels may result. This study reports expression levels of oxidative stress species in otosclerosis patients.