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Öğe Assessment of early decline in the percentage of ?-hCG values between days 0 and 4 after methotrexate therapy in ectopic pregnancy for the prediction of treatment success(Journal of the Turkish-German Gynecological Association, 2013) Çelik, Ebru; Türkçüoğlu, Ilgın; Karaer, Abdullah; Kırıcı, Pınar; Eraslan, SevilÖz: Amaç: Ektopik gebeliklerin tedavisinde methotraksat tedavisinin başarısını belirlemede beta-human koryonik gonadotropin (?-hCG) değerlerinin 0-1, 0-4 ve 0-7 günleri arasında yüzde değişimlerini değerlendirmek. Gereç ve Yöntemler: Ocak 2011 ile Agustos 2012 tarihleri arasında ektopik gebelik nedeniyle tanı alan ve tek doz metotreksat tedavisi alan 93 olgu çalışmaya dahil edildi. Elektronik ortamda kaydelilen hastaların dosyalarında bulunan tüm bilgiler incelendi. 0-1, 0-4 ve 0-7 günler arasındaki serum ?-hCG seviyelerindeki değişim yüzdeleri her olgu için hesaplandı. Bulgular: Metotreksat tedavisinin başarılı olan olguların %55.8 ve %89.6 da ortanca ?-hCG değerleri 0 ve 4. günler arasında azalmış olarak bulundu. Tedavi öncesindeki ortanca ?-hCG seviyesi tedavinin başarılı olduğu olgularda daha düşük saptanmasına rağmen iki grup arasında istatistiksel olarak bir fark saptanmadı (p=0.11). Sonuç: Serum ?-hCG değerlerindeki 0 ile 4. günler arasındaki düşme olması metoteksat tedavisinin başarısını tahmininde en iyi gösterge olarak ortaya çıkmaktadır, ve tek doz metotreksat ile tedavi edilen ekopik gebeliklerin nihai tedavinin başarısını belirlemek yararlı olacakır. (J Turkish-German Gynecol Assoc 2013; 14: 125-9)Öğe Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model(Bmc, 2018) Melekoglu, Rauf; Ciftci, Osman; Eraslan, Sevil; Cetin, Asli; Basak, NeseBackground: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model. Methods: POF in rats was induced by intraperitoneal injection of 200 mg/kg cyclophosphamide on day 1 and then 8 mg/kg/day for the following 14 days. After 14 days of cyclophosphamide administration, rats were randomly divided into three groups as follows (n = 10/group): POF, POF + CRC (100 mg/kg/day), and POF + CPS (0.5 mg/kg/day) to determine the effects of CRC and CPS on the cyclophosphamide-induced POF rat model. Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after the CRC and CPS treatments. Results: Malonaldehyde levels were significantly reduced, and glutathione levels and superoxide dismutase activity were significantly increased, in ovarian tissues in the POF + CRC and POF + CPS groups compared with the POF group. In the POF group, we observed hemorrhage and prominent mononuclear cell infiltration beneath the germinative epithelium, vascular congestion in ovarian stroma, hemorrhage around the corpus luteum, and atresia in ovarian follicles. This histopathological damage was significantly improved by treatment with CRC and CPS. There was a significant reduction in serum follicle-stimulating hormone and luteinizing hormone levels in rats treated with CRC and CPS compared with the POF group. Moreover, the levels of estradiol and anti-mullerian hormone in rats treated with CRC and CPS were significantly increased compared with the control group. Conclusions: In conclusion, CRC and CPS treatment of rats with cyclophosphamide-induced POF had a beneficial effect on reducing ovarian damage by improving tissue oxidative stress marker levels, ovarian reserve marker levels, and histopathological parameters. The significant improvements in ovarian tissue histopathological damage and hormonal levels detected in this study indicate that treatment with CRC or CPS might be a conservative treatment approach for cyclophosphamide-induced POF.Öğe The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model(Taylor & Francis Ltd, 2018) Melekoglu, Rauf; Ciftci, Osman; Eraslan, Sevil; Cetin, Asli; Basak, NeseThe objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation. Compared with the endometriosis control group, the average volume of the lesions was significantly lower in rats treated with hesperidin and nerolidol. Malondialdehyde levels were significantly reduced in the nerolidol-treated group, and glutathione levels and superoxide dismutase activity were significantly elevated in the endometriotic foci of both the hesperidin- and nerolidol-treated groups compared with the endometriosis group. Hesperidin and nerolidol treatment also improved histological parameters, such as hemorrhage, vascular congestion, necrosis, and inflammatory cell infiltration in the endometriotic foci. The results of this study demonstrated that treatment with the potent antioxidants nerolidol and hesperidin caused a significant regression of surgically induced endometriotic foci in rats.Öğe The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model(Gynecologıcal endocrınology, 2018) Melekoğlu, Rauf; Çiftlikci, Osman; Eraslan, Sevil; Çetin, Aslı; Basak, NeseThe objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation. Compared with the endometriosis control group, the average volume of the lesions was significantly lower in rats treated with hesperidin and nerolidol. Malondialdehyde levels were significantly reduced in the nerolidol-treated group, and glutathione levels and superoxide dismutase activity were significantly elevated in the endometriotic foci of both the hesperidin- and nerolidol-treated groups compared with the endometriosis group. Hesperidin and nerolidol treatment also improved histological parameters, such as hemorrhage, vascular congestion, necrosis, and inflammatory cell infiltration in the endometriotic foci. The results of this study demonstrated that treatment with the potent antioxidants nerolidol and hesperidin caused a significant regression of surgically induced endometriotic foci in rats.Öğe Çok düşük B-hCG düzeylerinde rüptüre tubal gebelik: olgu sunumu(2016) Duz, Senem Arda; Eraslan, Sevil; Coşkun, Ebru İnciÖz: Ektopik gebelik uterin kavitenin dışında oluşan gebeliktir. Sıklıkla tubada olmak üzere abdominal kavite, over ve servikste görülebilir. Ruptüre ektopik gebeliklere bağlı anne ölümleri günümüzde transvajinal sonografi ve serum ?-hCG (beta human koryonik gonadotropin) ölçümleri ile oldukça azalmıştır. Ancak ektopik gebeliğin kliniği ile ?hCGdüzeyi arasında bir korelasyon yoktur. Çok düşük ?-hCG düzeylerinde ektopik gebelik ruptürü gelişen bir olguyu sunmaktayız. Adet rötarı ile başvuran 29 yaşındaki nullipar hastanın serum ?-hCG düzeyi 1051 mIU/ml olup ultrasonografide tubal gebelik düşünülmüş, akut batın bulguları olmaması ve 3. gün serum ?-hCG düzeyi 727 mIU/ml olması üzerine haftalık takibe alınmıştır. Son vizitinden 2 gün sonra şiddetli alt karın ağrısı ile başvurdu. ?-hCG düzeyi 39.8 mIU/ml idi. Ultrasonografide abdomende yaygın mai izlendi, acil laparotomi, sağ salpenjektomi yapıldı. ?-hCG düzeyleri düşük ve azalmakta olsa bile rüptür ihtimali her zaman akılda tutulmalı ve hastalar da bu konuda bilgilendirilerek takip edilmelidir.Öğe Çok erken preterm prematür membran rüptüründe koryoamniyoniti öngörmede maternal delta nötrofil indeksinin yeri(Perinatoloji Dergisi, 2017) Melekoğlu, Rauf; Eraslan, Sevil; Çelik, Ebru; Gözde, Harika; Bağ, GözükaraÖz: Amaç: Bu çalışmada çok erken preterm prematür membran rüptürü ile komplike olan gebeliklerde koryoamniyoniti predikte etmede maternal delta nötrofil indeksinin kullanımını değerlendirmeyi ve bu indeksi diğer rutin enfeksiyon belirteçleriyle karşılaştırmayı amaçladık. Yöntem: ınönü Üniversitesi Tıp Fakültesi Hastanesi Kadın Hastalıkları ve Doğum Kliniği’ne 01.04.2014 – 01.01.2017 tarihleri arasında, gebeliğin 16–24. haftasında preterm prematür membran rüptürü nedeni ile başvuran ve bekleme yönetimi uygulanmış tüm hastaların dosyaları retrospektif olarak taranarak, çalışma kriterlerine uygun hastalar çalışmaya dahil edildi. Koryoamniyonitin olduğu serum lökosit, C reaktif protein (CRP), prokalsitonin ve delta nötrofil indeksi (DN‹) seviyelerinin cut-off değerlerini saptamak için receiver operating characteristic (ROC) e¤risi analizi kullanıldı ve sensitivite ve spesifite değerleri hesaplandı. Tüm analizlerde anlamlılık düzeyi 0.05 olarak kabul edildi. Bulgular: Çalışma kriterlerine uygun toplam 73 hasta saptandı. Bu hastalardan 43’ü (%58.9) izlem sırasında koryoamniyonit tanısı alırken, 30’unda (%41.1) koryoamniyonit saptanmadı. DNı için cut-off değeri %93.02 sensitivite, %93.33 spesifite ile 1.0 [area under receiver operating characteristic (AUROC) 0.943, %95 güven aralığı (CI) 0.863–0.984, p<0.0001], lökosit için cut-off değeri %51.16 sensitivite, %90 spesifite ile 13.9 (AUROC 0.650 %95 CI 0.529–0.758, p=0.0239), CRP için cut-off de¤eri %67.44 sensitivite, %76.67 spesifite ile 1.34 (AUROC 0.708, %95 CI 0.590– 0.808, p=0.0006) saptandı. Sonuç: Delta nötrofil indeksi çok erken preterm prematüre membran rüptürü gelişen hastalarda izlem sırasında koryoamniyonit prediksiyonunda kullanışlı olabilecek, tam kan sayımı ile birlikte bakılabilen, hızlı sonuç alınabilen, ek maliyet gerektirmeyen bir enfeksiyon belirteci olup testin diagnostik performans› CRP, prokalsitonin ve lökosite göre daha yüksek görünmektedir. Başlık (İngilizce): The use of maternal delta neutrophil index for the prediction of chorioamnionitis in very early preterm premature rupture of membranes Öz (İngilizce): Objective: In this study, we aimed to assess the use of maternal delta neutrophil index for the prediction of chorioamnionitis in pregnancies complicated with very early preterm premature rupture of membranes, and to compare this index with other routine infection markers. Methods: The files of all patients who admitted to the Obstetrics and Gynecology Clinic of Faculty of Medicine, ‹nönü University, due to preterm premature rupture of membranes between 16 and 24 weeks of gestation between April 1, 2014 and January 1, 2017 and applied expectant management were reviewed retrospectively, and the patients who were eligible for the inclusion criteria were included in the study. Receiver operating characteristic (ROC) curve analy is was used to determine cut-off values of serum leukocyte with chorioamnionitis, C-reactive protein (CRP), procalcitonin and delta neutrophil index (DNI) levels, and sensitivity and specificity values were calculated. In all analyses, 0.05 was considered as the significance level. Results: A total of 73 patients matching with inclusion criteria were identified. While 43 (58.9%) of these patients were diagnosed with chorioamnionitis, no chorioamnionitis was found in 30 (41.1%) patients. While the cut-off value for DNI was 1.0 [area under receiver operating characteristic (AUROC) 0.943, 95% confidence interval (CI) 0.863–0.984, p<0.0001] with 93.02% sensitivity and 93.33% specificity, it was 13.9 (AUROC 0.650 95% CI 0.529– 0.758, p=0.0239) for leukocyte with 51.16% sensitivity and 90% specificity, and 1.34 (AUROC 0.708, 95% CI 0.590–0.808, p= 0.0006) for CRP with 67.44% sensitivity and 76.67% specificity. Conclusion: Delta neutrophil index is an infection marker which may be useful for the prediction of chorioamnionitis during followup in patients who develop very early preterm premature rupture of membranes, can be checked by complete blood count, of which results can be obtained quickly and does not requires additional costs, and the diagnostic performance of the test seems higher than CRP, procalcitonin and leukocyteÖğe Early diagnosis of gestational diabetes mellitus during the first trimester of pregnancy based on the one step approach of the International Association of Diabetes and Pregnancy Study Groups(International Journal of Diabetes in Developing Countries, 2016) Melekoğlu, Rauf; Eraslan, Sevil; Çelik, Ebru; Çolak, CemilAbstract To examine the utility of the 75 g oral glucose tolerance test (OGTT), conducted according to the criteria of the International Association of Diabetes and Pregnancy Study Groups (IADPSG), for the early diagnosis of gestational diabetes mellitus (GDM) and to propose new cut-off values. A total of 350 prospectively enrolled patients were admitted to Inonu University School of Medicine Obstetrics and Gynecology Outpatient Clinic between April 2012 and January 2015 for first-trimester screening. Gestational diabetes mellitus (GDM) during the first trimester of pregnancy (11–13 weeks) was diagnosed using the 75-g OGTT. In patients who tested negative, the OGTT was repeated at 24– 28 weeks. GDM was diagnosed in 14.6% of the patients, of whom 80.3% were diagnosed during the first trimester. In these patients, there were no remarkable changes in fasting plasma glucose level when a fasting glucose cutoff of 92 mg/dl was used for the diagnosis of GDM. The sensitivity and specificity of the OGTT were 66.6% and 99.3%, respectively (area under the receiver operating characteristic curve [AUROC] 0.892, 95% CI 0.855–0.923, p < 0.001). The cutoff value for a positive 75-g OGTT result was reduced from 180 to 173 mg/dl for the 1-h post-glucose load (AUROC 0.908, 95% CI 0.873–0.936, p < 0.001) and from 153 to 129 mg/dl for the 2-h post-glucose load (AUROC 0.861, 95% CI 0.515– 0.775, p < 0.001). The 75-g OGTT based on IADPSG criteria can be used to detect 80% of GDM cases as early as the first trimester. A modification of current cutoff values would improve the sensitivity of the test but lower its specificity.Öğe The Effects of Body Mass Index on Second-Trimester Amniotic Fluid Cytokine and Matrix Metalloproteinase Levels(Karger, 2018) Melekoglu, Rauf; Ciftci, Osman; Eraslan, Sevil; Basak, Nese; Celik, EbruAim: The aim of this study was to determine the effects of obesity on amniotic fluid (AF) inflammatory markers in second-trimester AF, testing the hypothesis that there is a relationship between maternal body mass index (BMI) and fetal inflammatory exposure. Methods: AF was obtained from 84 singleton pregnant women undergoing elective amniocentesis for karyotype analysis at 16-24 weeks of gestation between April 2014 and May 2016. The cell-free AF was used to analyze interleukin (IL)-1 beta and IL-6, and matrix metalloproteinase (MMP)-1, MMP-6, and MMP-13. Results: IL-1 beta levels were significantly higher in class II-III obese patients than in class I obese, overweight, and normal weight patients (14.68 +/- 1.37 vs. 13.34 +/- 1.86 vs. 13.00 +/- 2.22 vs. 10.78 +/- 1.92, respectively; p < 0.05). IL-6 levels were lowest in the normal weight group and highest in class II-III obese patients. MMP-1, MMP-6, and MMP-13 levels were also significantly higher in class II-III obese patients than in the other groups. Conclusion: This study demonstrated that the fetuses of class II-III obese women are exposed in utero to higher cytokine and MMP levels than fetuses of lean women. Modification of current cutoff levels of intra-amniotic cytokines and MMPs according to the BMI could improve the accuracy of the prenatal diagnosis of intra-amniotic infection and inflammation. (C) 2017 S. Karger AG, BaselÖğe İdiyopatik trombositopenik purpuralı gebelerin maternal ve neonatal sonuçları(2017) Melekoğlu, Rauf; Eraslan, Sevil; Baştemur, Ayşe Gülçin; Çelik, Ebru; Gözükara Bağ, HarikaÖz: Amaç: Bu çalışmada kliniğimizde gebelik takibi ve doğumu gerçekleştirilen idiyopatik trombositopenik prupura (ITP) tanısı almış gebelerin maternal ve neonatal sonuçlarını ortaya koymayı amaçladık. Yöntem: Çalışmamızda inönü Üniversitesi Tıp Fakültesi Hastanesi Kadın Hastalıkları ve Doğum Kliniği’nde, 01.01.2010 – 01.01.2017 tarihleri arasında gebelik takibi ve doğumu gerçekleştirilen idiyopatik trombositopenik purpural› gebelerin ve yenidoğanların dosyalar› retrospektif olarak taranarak, çal›flma kriterlerine uygun hastalar çal›flmaya dahil edildi. Bulgular: Çalşma periyodu boyunca ITP tan›s› ile izlenen 68 hastadan 12’sinin (%17.6) gebelik s›ras›nda, 56’s›n›n (%82.4) ise gebelik öncesi ITP tan›s› ald›ğ› saptand›. Do¤um s›ras›nda trombosit say›s› 50×109 /l’nin alt›nda olan hastalarda steroid kullan›m›, trombosit say›s› 50×109/l’nin üstünde olan hastalara göre istatistiksel olarak anlaml› düzeyde yüksek bulundu (p=0.003). Trombosit say›s› >50×109 /l olan ITP’li gebe grubunda 13 (%29.5) hastada, trombosit say›s› <50×109 /l olan gebe grubunda ise 1 (%4.2) hastada gebelik öncesinde splenektomi operasyonu geçirme öyküsü izlendi (p=0.013). Doğum flekli sezaryen olan hasta grubu ile vajinal doğum olan hasta grubu aras›nda yenidoğan yoğun bak›m ihtiyac› ve yenidoğan tedavi gereksinimi aç›s›ndan anlamlı fark izlenmedi (s›ras›yla p=0.889 ve p=0.598). Doğum s›ras›nda 6 (%8.8) hastada postpartum kanama gözlenirken, 17 (%25) hastada trombosit aferez, 5 (%7.3) hastada intravenöz immunglobulin (IVIG), 8 (%13.2) hastada ise trombosit aferez ile birlikte IVIG tedavisi kullan›ld›. Doğumda maternal trombosit say›s› ile doğumda yenido¤an trombosit say›s› aras›nda anlaml› ilişki saptanmad› (p=0.625; r=0.06). Sonuç: ITP’li gebelerin maternal ve neonatal prognozu genellikle iyidir. Gebelik sırasında maternal trombosit sayısının <50×109 /l olması gebelik sırasında daha fazla medikal tedavi gereksinimi ve doğum sırasında daha fazla kan ürünü ihtiyac› ile ilişkili olup doğum fleklinin perinatal sonuçlar üzerine etkisi görünmemektedir.Öğe Ipsilateral clavicle and humerus diaphysis fractures in newborn after vaginal delivery; a very rare case report(Taylor & Francis Inc, 2022) Celik, Metin; Arikan, Emre; Eraslan, Sevil; Tastan, Songul Celik[Abstract Not Available]Öğe Metabolic and carbohydrate characteristics of different phenotypes of polycystic ovary syndrome(Aves, 2016) Celik, Ebru; Turkcuoglu, Ilgin; Ata, Baris; Karaer, Abdullah; Kirici, Pinar; Eraslan, Sevil; Taskapan, CagatayObjective: To compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism. Material and Methods: This is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated. Results: Women with PCOS diagnosed according to the AE Society had a significantly higher prevalence of metabolic syndrome compared with the normoandrogenemic PCOS phenotype: odds ratio (OR) 2.95 [95% confidence interval (CI) 1.21-7.21]. There was no significant difference in the prevalence glucose intolerance test between the groups [OR: 2.15, 95% CI 0.71-6.56]. The prevalence of low high density lipoprotein (HDL)-cholesterol in the group under the AE-PCOS Society criteria was higher than that of the normoandrogenemic PCOS group [OR: 2.82, 95% CI 1.29-3.36]. Conclusion: The risks of metabolic syndrome and cardiovascular disease may vary among the phenotypes of PCOS based on the Rotterdam criteria. This new data may be of reference in informing women with PCOS, although further prospective studies are needed to validate this proposition.Öğe Perinatal and Neonatal Outcomes of Patients Who Were Diagnosed with Neural Tube Defect in Midtrimester Fetal Ultrasound Scan and Refused Request for Termination of Pregnancy(Hindawi Ltd, 2016) Melekoglu, Rauf; Eraslan, Sevil; Celik, Ebru; Simsek, YavuzObjectives. In this study, we aimed to demonstrate the perinatal and neonatal outcomes of patients who were diagnosed with neural tube defect (NTD) in the midtrimester fetal ultrasound scan and refused the request for termination of pregnancy. Material and Methods. The records of 69 patients, for whom NTD was detected in the midtrimester fetal ultrasound scan and who preferred the continuation of the pregnancy after comprehensive counselling about the possible prognosis and treatment options during the period between January 2011 and February 2016, were reviewed retrospectively. Results. Of these patients, 66.7% were 25-35 years old; 95.7% were multiparous; and 1.4% had a history of a fetus having NTD in previous pregnancies. There were 7 (10.1%) neonatal deaths in these patients. Meningomyelocele closure procedure was the most performed surgery in the postnatal period (92%). Of these patients, 30.7% had paraplegia; 51.6% had neurogenic bladder; and 6.4% had infections due to surgery. Conclusion. The results of this study demonstrated perinatal and neonatal outcomes of fetuses with NTD who were not terminated by the preference of the family in midtrimester. The experience of our centre would be beneficial as a tool for nondirective counselling of these patients when considering the antenatal/postnatal care options and postnatal prognosis.Öğe Prematür ovaryan yetmezlik etyopatogenezinde plazma ağır metal (kadmiyum) düzeylerinin rolü(İnönü Üniversitesi, 2016) Eraslan, SevilAmaç: Prematür ovaryan yetmezlik tanısı alan hastalarda serum kadmiyum düzeyi saptanarak prematür ovaryan yetmezlik etyopatogenezinde ağır metal maruziyetinin etkisinin olup olmadığının ortaya konulması amaçlanmıştır. Gereç ve Yöntemler: 2014 ile 2015 yılları arasında İnönü Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı Üreme Endokrinolojisi ve İnfertilite Bilim Dalı polikliniklerine başvurmuş olan prematür ovaryan yetmezlik tanısı almış olan 35 hasta, 24-39 yaş arasında, düzenli adet gören 35 kontrol ve doğal menopoza girmiş olan 35 kontrol olmak üzere toplam 105 hasta çalışmaya dahil edildi. Hastaların yaş, vücut kitle indeksi, hormon profilleri, sosyoekonomik durumları ve serum kadmiyum düzeyleri karşılaştırıldı. Bulgular: Olguların gravida, parite, yaşayan çocuk oranları, emzirme süreleri, serum FSH, LH ve E2 düzeyleri açısından gruplar arasında istatistiksel olarak anlamlı fark bulunurken; yaş, abortus öyküsü, vücut kitle indeksi, medeni hali, menstrüasyon yaşı, öğrenim durumu, yerleşim yeri, sigara ve alkol kullanımı, gelir düzeyi, meslek, günlük sedanter geçirilen zaman ve fiziksel aktivite, oral kontraseptif kullanımı, kronik hastalık, cerrahi öyküsü, aile öyküsü ve kemoterapi/radyoterapi maruziyeti açısından gruplar arasında istatiksel olarak anlamlı fark yoktu. Kadmiyum düzeyleri prematür ovaryan yetmezliği olan grupta, kontrol gruplarına göre istatistiksel olarak anlamlı düzeyde düşük saptandı. Sonuç: Yapılan birçok çalışmada ağır metal maruziyetinin üreme sağlığı üzerine olumsuz etkileri gösterilmiş olmasına rağmen premetür ovaryan yetmezlik ile ilişkisi bulunamamıştır.Öğe The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries(Hindawi Ltd, 2018) Melekoglu, Rauf; Ciftci, Osman; Eraslan, Sevil; Alan, Saadet; Basak, NeseObjective. To evaluate the protective effects of glycyrrhetinic acid (GA) and chrysin (CH) on experimental ischemia-reperfusion (I/R) injury in rat ovaries using tissue oxidative stress marker levels, hormone levels, and histopathological scores. Methods. Sixty healthy rats were randomly divided into six equal groups: control, I/R, I/R + CH (50 mg/kg/day), I/R + GA (100 mg/kg/day), CH (50 mg/kg/day), and GA (100 mg/kg/day). Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after CH and GA treatment. Results. The antioxidant defense system parameters were significantly higher in the ovarian tissues of the I/R + CH and I/R + GA groups than in those of the I/R group. Serum follicle-stimulating hormone levels were significantly reduced, and serum anti-Mullerian hormone levels were significantly increased in rats treated with CH and GA compared with those in the I/R group. Additionally, the histopathological scores of the I/R + CH and I/R + GA groups were significantly improved compared with those of the I/R group. Conclusions. The significant improvements in tissue oxidative stress parameters, serum hormone levels, and histological scores observed in this study indicate that treatment with CH or GA may be a conservative approach to prevent I/R injury in adnexal torsion cases after the ovarian detorsion procedure.Öğe The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats(Acta Cirurgica Brasileira, 2018) Yilmaz, Ercan; Melekoglu, Rauf; Ciftci, Osman; Eraslan, Sevil; Cetin, Asli; Basak, NesePurpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (lOOmg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
