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    Comparison of major coronary risk factors in female and male patients with premature coronary artery disease
    (Taylor & Francis Ltd, 2008) Yasar, Ayse Saatci; Turhan, Hasan; Basar, Nurcan; Metin, Fatma; Erbay, Ali Riza; Ilkay, Erdogan; Sabah, Irfan
    Objective -The present study was designed to analyse and compare the major coronary risk factors of female and male patients with premature coronary artery disease (CAD) aged <= 45 years. Methods - We evaluated 4613 consecutive patients who underwent coronary angiography at our institution; 572 symptomatic patients (489 men and 83 women) diagnosed as having premature CAD (age <= 45 years) were included in our analysis. For each patient, the presence of major coronary risk factors such as family history of CAD, hypercholesterolaemia, diabetes mellitus, hypertension and cigarette smoking were recorded. Besides, clinical presentation and angiographic findings were also recorded. Results - The most common risk factor was cigarette smoking in young men (70.3%). However, the major coronary risk factor was hypercholesterolaemia in young women (67.5%).When we compared two groups with respect to major coronary risk factors, we found that the prevalence of diabetes mellitus and hypertension were significantly higher in young women than in young men (diabetes mellitus: 27.7% vs. 12.3%, respectively, P < 0.001, hypertension: 56.6% vs. 23.4%, respectively, P < 0.00 1). However, cigarette smoking was found to be significantly higher in men than in women (70.3% vs. 28.9% respectively, P < 0.00 1). Conclusion - We have shown for the first time the impact of gender on the coronary risk factor profile in young Turkish patients with premature CAD.These findings may be useful for gender-based management and risk factor modification of young patients with premature CAD.
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    Relationship of serum calprotectin, angiopoietin-1, and angiopoietin-2 levels with coronary collateral circulation in patients with stable coronary artery disease
    (Polskie Towarzystowo Kardiologiczne, 2019) Demir, Vahit; Ede, Huseyin; Ercan, Mujgan; Turan, Yasar; Hidayet, Siho; Inandiklioglu, Nihan; Erbay, Ali Riza
    BACKGROUND In patients with chronic stable coronary artery disease (CAD), well-developed coronary collateral circulation (CCC) is known to reduce long-term mortality. AIMS The objective of this study was to determine the relationship of serum calprotectin (S100A8 /S100A9), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) concentrations with CCC in patients with stable CAD. METHODS This prospective cross-sectional study included 147 patients with stable angina pectoris. The Cohen-Rentrop classification was used to assess CCC. Patients were divided into 2 groups: with poor CCC (Cohen-Rentrop score, 0-1; n = 79) and with good CCC (Cohen-Rentrop score, 2-3; n = 68). Serum calprotectin, Ang-1, and Ang-2 concentrations were compated between groups. RESULTS Compared with the group with good CCC, serum calprotectin and Ang-1 levels were higher (P <0.01 and P<0.001, respectively), while serum Ang-2 levels were lower (P<0.01) in the poor-CCC group. C-reactive protein levels showed a moderate positive correlation with calprotectin levels (r = 0.359; P <0.001). In a multivariate regression analysis, only calprotectin (P <0.05) and Ang-1 (P <0.05) were found to be independent predictors of good and poor CCC. CONCLUSIONS Our study showed that Ang-2 levels were lower, while serum calprotectin and Ang-1 levels were higher, in patients with stable CAD and poor CCC regardless of the complexity and severity of coronary arteriosclerosis. If these results are confirmed in future studies, calprotectin may be considered a useful biomarker for guiding anti-ischemic treatment.