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    Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?
    (2020) Erbay, Guven; Ozden, Cuneyt; Baykam, Mehmet Murat; Gokkaya, Cevdet Serkan; Tagci, Suleyman
    Aim: To evaluate the effect of coexistent extracapsular extension and seminal vesicle invasion on biochemical reccurence free survival rates in patients who had undergone open radical retropubic prostatectomy.Material and Methods: The data of 307 patients with clinically localized prostate cancer who had undergone radical retropubic prostatectomy between January 2000 and May 2019 were evaluated retrospectively. According to extension of tumor on surgical specimens, patients were classified into five groups as; organ-confined disease, extracapsular extension, isolated seminal vesicle invasion, extracapsular extension in addition to seminal vesicle invasion and lymph node involvement. Patient groups were analyzed categorically with regard to biochemical reccurence free survival rates by using Kaplan Meier analysis, log-rank and chi-square tests. The effect of pathological features of surgical specimens on biochemical reccurence was evaluated by using univariate and multivariate Cox regression analysis.Results: There were statistically significant differences on biochemical reccurence free survival rates among the five groups, and pathological stage and biochemical reccurence rates increased correspondingly. Multivariate Cox regression analysis showed that coexistent extracapsular extension and seminal vesicle invasion, and lymph node involvement are the two significant factors that negatively effect the biochemical reccurence free survival rate.Conclusion: Coexistence of extracapsular extension and seminal vesicle invasion is a worse prognostic factor compared to their isolated forms.
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    The relationship between ProNT BNP levels and erectile dysfunction in patients with chronic congestive heart failure
    (2021) Ceyhun, Gokhan; Erbay, Guven
    Aim: Dysfunction and impairment of many organs occur in chronic congestive heart failure due to ischemia and stasis. Chronic congestive heart failure is frequently accompanied by erectile dysfunction since the two conditions have many etiologic factors in common. Our aim in the study was to investigate the potential relationship between ProNT BNP levels, which show the severity of cardiac failure, and erectile dysfunction in patients with an ejection fraction of 30-40%. Materials and Methods: The study included 72 male patients followed-up for chronic congestive heart failure. for whom erectile dysfunction was investigated. International Erectile Function Index-5 (IIEF-5) questionnaire was questioned to the patients to evaluate erectile function.Results: The mean age, total testosterone and lipids (low and high-density lipoprotein cholesterol triglyceride) levels did not significantly differ between the groups (P > 0.05). The mean ProNT BNP levels belonging to all subgroups showed statistically significant differences and correlated with the severity of erectile dysfunction according to the Kruskal-Wallis test (p0.001).Conclusions: In patients with chronic congestive heart failure, ProNT BNP was higher, and the severity of erectile disfunction was similarly increased.