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Öğe Analysis of changes in brain morphological structure of taekwondo athletes by diffusion tensor imaging(Elsevier, 2023) Kurtoglu, Erdal; Payas, Ahmet; Duz, Serkan; Arik, Mustafa; Ucar, Ilyas; Tokmak, Turgut Tursem; Erbay, Mehmet FatihObjective: Taekwondo, which is the most preferred sport among the martial arts, is known to improve individuals physically, spiritually and mentally. The aim of this study is to reveal the effect of teakwondo sport on the brain and brain structures.Design;: 30 taekwondo athletes and 15 control groups were included in this study. Diffusion tensor MR images of each participant were taken. The information was obtained by the self-declaration of the athletes, whether they were sports years, amateur or elite.Method: Total brain volume and volumes of white matter, gray matter, frontal lobe, precentral gyrus, cortico-spinal tract, basal nuclei, postcentral gyrus, hippocampus and amigdala and the ratio of these volumes to total brain volume were evaluated statistically between the groups using MriCloud software and ROIEditor program.Results: An increase in total brain volume, gray matter, frontal lobe and precentral gyrus volume in athletes was associated with taekwondo training. When the ratio of brain parts to total brain volume was examined, it was determined that there was a difference in the ratio of gray matter, white matter volumes in amateur athletes, right frontal lobe, left corticospinal tract, right postcentral gyrus volumes in elite athletes, and left postcentral gyrus volumes of both athletes compared to sedentary individuals.Conclusions: The increase in the volume of gray matter, frontal lobe, postcentral gyrus and corticospinal tract together with the brain volume shows that taekwondo exercise contributes to physical, spiritual and mental development.Öğe Bakır Metabolizması Bozuklukları(2023) Erbay, Mehmet Fatih; Karatoprak, Nur BetülBakır, tüm canlılarda oksidatif metabolizma için hayati öneme sahip, beynin normal gelişimi ve fonksi- yonel devamlılığı için gerekli bir elementtir. Vücuttaki homeostazisi hassas olarak korunur. Bu dengenin bozulması nörodejeneratif hastalıklara zemin hazırlamaktadır. Bu hastalıklar için en tipik iki örnek Menkes (MH) ve Wilson hastalıklarıdır (WH). Başka nörodejeneratif hastalıklar da bozulmuş bakır homeostazisi ile ilişkilendirilmekte ancak bu hastalıkların gelişimde bakırın rolü MH ve WH’nin aksine henüz tam olarak anlaşılabilmiş değildir.Öğe Bilirubin Ensefalopati(2023) Erbay, Mehmet Fatih; Şahin, TunaBilirubin, heme yıkımının metabolik son ürünüdür. Fizyolojik serum seviyelerinde antioksidan etkiye sahip olabilen bilirubin, aşırı arttığında toksik etkiler göstermeye başlar. Özellikle serumda 20 g/dL’nin üzerine çıktığında beyinde belli yerlerde birikerek akut dönemde ölümcül, ilerleyen dönemlerde ise bir çok nöro- lojik bozukluk ile karakterize kernikterus diye bilinen bilirubin ensefalopati tablosunu ortaya çıkartır. Akut dönemde en sık manyetik rezonans görüntüleme bulgusu globus pallidusda T1 hiperintensitedir. İlerleyen dönemde bu görünüm T2 hiperintensiteye evrilir.Öğe Brain metabolite rates in amygdala and hippocampus in vaginismus patients(2020) Erbay, Mehmet Fatih; Porgalı Zayman, EsraAbstract: Vaginismus has complex etiology. Regarding its clinical manifestation, it is a condition associated with anxiety and fear. The fact that hippocampus and amygdala are critical regions for the modulation of anxiety suggests that they might be playing a role in the neurobiology of vaginismus. In the present study, therefore, we aimed to investigate the concentrations of cerebral metabolites in both the amygdala and hippocampus in vaginismus patients and healthy controls via magnetic resonance spectroscopy method. A total of 39 vaginismus patients and 26 sexually active healthy controls were enrolled into the study. All the patients and healthy controls underwent magnetic resonance spectroscopy procedure. Comparison of the groups revealed no difference in terms of concentrations of cerebral metabolites in the amygdala, whereas median Cholin (Cho) concentration in the hippocampus was significantly higher in the patient vs. the control group. High concentration of Cho in the hippocampus of vaginismus patients might be indicating the changes in myelination or signal transduction in the relevant region. Considering the role of the hippocampus in fear con-ditioning and fear memory, such changes in the patients are considered as the neurobiological reflections of fear conditioning. Repeated and further studies will further contribute to the clarification of this subject.Öğe Brain Tumors and Atypical Psychiatric Symptoms: Two Case Presentations(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2018) Akan, Mustafa; Erbay, Lale Gonenir; Erbay, Mehmet Fatih; Unal, Suheyla[Abstract Not Available]Öğe Brain tumors and atypical psychiatric symptoms: two case presentations(Yerkure tanıtım & yayıncılık hızmetlerı a s, cumhuryet cad 48-3b, harbıye, ıstanb, 34367, turkey, 2018) Akan, Mustafa; Erbay, Lale Goneni; Erbay, Mehmet Fatih; Unal, SuheylaÖğe Can T2 blackout effect be a marker of iron accumulation in brains of multiple sclerosis patients?(British Inst Radiology, 2020) Erbay, Mehmet Fatih; Kamisli, Ozden; Karatoprak, Nur BetulObjective : T2 blackout (TBO) effect, which is a common finding in the brains of multiple sclerosis (MS) patients and older population that are imaged for other reasons on diffusion weighted imagings (DWI) and apparent diffusion coefficient (ADC) map show the existence of paramagnetic materials in the tissue. Because iron is known to accumulate in especially deep gray matter (DGM) structures in MS brains, we aimed to investigate the relationship between TBO and clinico-radiological parameters that may be iron-related in MS. Methods: We retrospectively reviewed the latest MR images of MS patients on 3 Tesla MR scanner between 2018 and 2019. TBO existence and severity on DWI-ADC was assessed by two radiologists and its correlation with several outcomes of MS was investigated. Results: No significant relationship was found between TBO and gender, subtype of MS whereas TBO was positively correlated with parameters such as black-hole lesions, cortical atrophy, duration of disease, age and extended disability status scale (EDSS) score. Conclusions: TBO shows correlation with the conditions which were revealed to be associated with iron accumulation in the brain of MS patients in the literature. Therefore, we concluded that TBO and its severity in DGM may represent iron accumulation in MS brains. Advances in knowledge: TBO effect as a frequent imaging finding in daily practice may be used as predictor of the disease course of MS due to possible effects of iron accumulation in brain and thereby may be useful in modifying treatment strategies.Öğe A case of gliosarcoma in a child with neurofibromatosis type 1(2020) Dogan, Gulec Mert; Sigirci, Ahmet; Cengiz, Aslinur; Erbay, Mehmet Fatih; Gokce, HasanGliosarcoma (GS) is a rarely seen form of glioblastoma. These tumors are mostly seen in males older than 60 years of age. It is extremely rare in pediatric central nervous system (CNS) tumors. In this case report, we present a 3-year-old boy with a giant gliosarcoma. Magnetic resonance (MR) imaging and histopathologic findings are discussed. A 3 year-old boy with a clinically diagnosed NF-1 was admitted to the emergency department with a complaint of intractable vomiting. Magnetic resonance imaging (MRI) of the brain was suggestive of a large lobulated mass lesion in the left parietal lobe extending to the vertex and slightly compressing the left lateral ventricle. The final histopathologic diagnosis of the tumor was considered as gliosarcoma. To our knowledge, this case constitutes the first youngest case with neurofibromatosis type 1 reported in the literature in all pediatric cases of GS.Öğe A case of gliosarcoma in a child with neurofibromatosis type 1(2020) Doğan, Güleç Mert; Sığırcı, Ahmet; Cengiz , Aslınur; Erbay, Mehmet Fatih; Gökçe, HasanAbstract: Gliosarcoma (GS) is a rarely seen form of glioblastoma. These tumors are mostly seen in males older than 60 years of age. It is extremely rare in pediatric central nervous system (CNS) tumors. In this case report, we present a 3-year-old boy with a giant gliosarcoma. Magnetic resonance (MR) imaging and histopathologic findings are discussed. A 3 year-old boy with a clinically diagnosed NF-1 was admitted to the emergency department with a complaint of intractable vomiting. Magnetic resonance imaging (MRI) of the brain was suggestive of a large lobulated mass lesion in the left parietal lobe extending to the vertex and slightly compressing the left lateral ventricle. The final histopathologic diagnosis of the tumor was considered as gliosarcoma. To our knowledge, this case constitutes the first youngest case with neurofibromatosis type 1 reported in the literature in all pediatric cases of GS.Öğe A Case of High Grade Glioma following Treatment of Relapsing-remitting Multiple Sclerosis with Fingolimod(Wolters Kluwer Medknow Publications, 2020) Erbay, Mehmet Fatih; Kamisli, OzdenMultiple sclerosis is a major cause of neurological disability, especially in young adults. There have been several case reports of an increased risk of cancer after long-term treatment for multiple sclerosis. Fingolimod is an immunomodulating agent used in the treatment of relapsing -remitting multiple sclerosis. The side effects commonly associated with tingolimod are cardiac side effects, macular edema, and elevated liver enzyme levels. Increased risks of infection and cancer have also been reported. High grade glioma is an aggressive primary brain tumor. There has been one case report of high grade glioma during fingolimod treatment. Here, we report the case of a 58-year-old woman diagnosed with glioblastoma multiforme after one year of tingolimod treatment for multiple sclerosis.Öğe A Comparison of Dual-Energy CT with MRI in the Detection of Traumatic Bone Marrow Edema in Distal Extremity Bones(Erciyes Univ Sch Medicine, 2023) Kaya, Ahmet Turan; Ozdemir, Zeynep Maras; Erbay, Mehmet Fatih; Kahraman, Aysgul Sagir; Karaca, Leyla; Karakaplan, Mustafa; Gurbuz, SukruObjective: Our objective was to evaluate the performance of dual-energy computed tomography (DECT) in detecting post-traumatic bone marrow edema (BME) in distal extremities.Materials and Methods: We prospectively studied 31 consecutive patients (25 males) who presented within the first four weeks following distal extremity traumas (wrist, n=19; ankle, n=14) (protocol number: 2017/74). All patients underwent DECT and magnetic resonance imaging (MRI) within three days of presentation. Two independent radiologists analyzed DECT images for fractures and BME qualitatively. Computed tomography (CT) numbers on Virtual non-calcium (VNCa) images were obtained in both edematous and non-edematous areas for quantitative consensus assessment. We used MRI as a reference standard. Results: MRI identified BME in 56/71 bones (78.9%). The rates of BME detection on CT compared to MRI at the patient level were found to be statistically significantly lower, ex-cept for individuals over 40 years of age, women, those with 7-30 days between trauma and admission, and those with CT-detected fractures (p<0.05). The rates of BME detection on CT at the bone level, compared to MRI, were found to be statistically significantly lower (p<0.01), except for women and those with fractures detected on CT. The interobserver agreement for the qualitative analysis of BME was fair (kappa=0.407 and p<0.001). DECT's diagnostic accuracy rates in predicting BME were significantly higher in patients with fractures (p=0.028). CT numbers in edematous areas were significantly higher than in non-edematous areas (p<0.001).Conclusion: DECT may serve as an alternative for detecting post-traumatic BME in distal extremity bones. However, in our heterogeneous bone sample group, it exhibited low sensitivity and a low negative predictive value.Öğe Concordance of diffusion tensor imaging alterations with EEG lateralization in MR negative refractory temporal lobe epilepsy(2020) Erbay, Mehmet Fatih; Kamışlı, ÖzdenAbstract: Aim: In this study, we aimed to investigate the occult microstructural changes in both temporal lobes and their localization concordance with electroencephalogram (EEG) lateralization side in MR negative refractory temporal lobe epilepsies using diffusion tensor imaging (DTI). Material and Methods: Clinical files of 200 adult patients diagnosed with temporal lobe epilepsy and followed by neurology department were reviewed. A total of 32 patients who had uncontrolled seizures despite antiepileptic medication and had normal MR findings were included in the study. Using DTI data, symmetric region of interests (ROIs) were replaced on each temporal white matter to calculate parameters including fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD). Mean values of each of these parameters were compared between the epileptogenic lateralization side on (EEG) and opposite temporal lobe. Results: FA and RD values were significantly different on lateralization side compared to normal side, whereas AD value showed no significant difference between two sides. Conclusion: The subtle microstructural abnormalities which cannot be discerned on routine conventional MRI practice in brains of refractory TLE patients can be revealed by DTI. The localization of these DTI abnormalities mostly shows concordance with the lateralization side on EEG. Awareness of the existence and degree of these alterations may be useful in determining medical treatment strategies or may be a guide in planning blind antiepileptic surgery.Öğe Concordance of diffusion tensor imaging alterations with EEG lateralization in MR negative refractory temporal lobe epilepsy(2020) Erbay, Mehmet Fatih; Caliskan Kamisli, OzdenAim: In this study, we aimed to investigate the occult microstructural changes in both temporal lobes and their localization concordance with electroencephalogram (EEG) lateralization side in MR negative refractory temporal lobe epilepsies using diffusion tensor imaging (DTI).Material and Methods: Clinical files of 200 adult patients diagnosed with temporal lobe epilepsy and followed by neurology department were reviewed. A total of 32 patients who had uncontrolled seizures despite antiepileptic medication and had normal MR findings were included in the study. Using DTI data, symmetric region of interests (ROIs) were replaced on each temporal white matter to calculate parameters including fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD). Mean values of each of these parameters were compared between the epileptogenic lateralization side on (EEG) and opposite temporal lobe.Results: FA and RD values were significantly different on lateralization side compared to normal side, whereas AD value showed no significant difference between two sides.Conclusion: The subtle microstructural abnormalities which cannot be discerned on routine conventional MRI practice in brains of refractory TLE patients can be revealed by DTI. The localization of these DTI abnormalities mostly shows concordance with the lateralization side on EEG. Awareness of the existence and degree of these alterations may be useful in determining medical treatment strategies or may be a guide in planning blind antiepileptic surgery.Öğe Effects of contrast material on the metabolite ratios in single-voxel MR Spectroscopy of intraaxial brain tumors(Churchill Livingstone, 2012) Alkan, Alpay; Burulday, Veysel; Oztanir, Namik; Dogan, Metin; Erbay, Mehmet Fatih; Kocak, Ayhan; Aralasmak, AyseAim: The purpose of our study was to determine whether the administration of contrast material affects the results of MR Spectroscopy (MRS) in different intraaxial brain tumors. Materials and methods: Thirty-three patients (median range 46.72 +/- 2.95, range 9-77) with intraaxial brain tumors underwent MRS before and 5 min after intravenous administration of gadolinium based contrast material at the standard dose of 0.1 mmol/kg (Gadodiamide or Gd-DOTA). Metabolite ratios (N-acetyl aspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr. and NAA/Cho) were calculated. Results: There was no significant difference between the pre and postcontrast MRS spectra as regards to NAA/Cr (p:0.4), Cho/Cr (p:0.2), and NAA/Cho (p:0.2) ratios obtained from the intraaxial brain tumors. Conclusion: Contrast material administration did not change the metabolite ratios of MRS. Contrast administration would be useful in guiding voxel localization in MRS evaluation of intraaxial brain tumors. (C) 2012 Elsevier Ltd. All rights reserved.Öğe The effects of residual parotid volume on symptom-specific quality of life and complications in patients undergoing parotid surgery(Springer, 2021) Aydin, Sukru; Erbay, Mehmet Fatih; Kizilay, AhmetPurpose To measure postoperative residual parotid volumes in parotidectomy patients and to measure the effect of residual parotid volumes on the symptom-specific quality of life (SSQOL) and complications. Methods Between January 2010 and December 2016, 148 parotid gland surgeries were performed, and 74 patients were included in the study. Bilateral parotid gland volumes were measured by Magnetic Resonance Imaging (MRI). Parotidectomy Outcome Inventory-8 and aesthetic scale questionnaire were applied to the patients. The volumetric averages obtained were compared with the questions in the SSQOL scale, the aesthetic scale data, and complications. Results In the volumetric examination performed with MRI, the mean residual volumes of the operated parotid glands were 9.5 cm(3), while the non-operated side was 28.8 cm(3). The width of the surgery and the residual parotid tissue volume was inversely correlated. There was a statistically significant difference between the residual parotid gland volume and the pain related to the surgical area, depression in the surgical site, Frey's syndrome, incision scar, and numbness. As the residual parotid gland volumes decreased, the patients' cosmetic problems related to the surgical field increased significantly, and their SSQOL decreased. Conclusion Postoperative residual parotid tissue volume could be an objective parameter to measure patients' SSQOL and complications. After parotidectomy, the maximum amount of disease-free tissue of the parotid gland should be left in place to increase patients' quality of life and minimize complications.Öğe Evaluation of CSF flow dynamics in patients with schizophrenia using phase-contrast cine MRI(Elsevier Ireland Ltd, 2021) Kartalci, Sukru; Erbay, Mehmet Fatih; Kahraman, Aysegul; candir, Fatih; Erbay, Lale GonenirPatients with schizophrenia show progressive clinical deterioration. Brain abnormalities have been suggested in these patients, including enlargement of the lateral ventricles, increased cerebrospinal fluid (CSF) volume and reductions in the frontal and temporal lobes. CSF flow pathology is a central factor in the development of many neurological disorders, but much less is known about the role of CSF flow dynamics in schizophrenia. In this study, parameters of CSF flow dynamics at the aqueduct level of 50 schizophrenic patients were compared to those of 50 controls using phase-contrast cine magnetic resonance imaging. Patients had lower peak velocity, lower net forward volume, and lower average flow over the range studied than controls. The average velocity was significantly lower in patients exhibiting violent behavior compared to non-violent patients. The aqueduct tendedto be larger in schizophrenic patients with earlier age of onset of the disorder. Furthermore, as the number of hospitalizations increased, the average velocity and flow over the range studied decreased commensurately. This study demonstrated that CSF flow dynamics are altered in patients with schizophrenia. The results indicated that additional studies of CSF flow dynamics in schizophrenia are needed, along with volumetric examinations of the brain, to elucidate the pathophysiology of the disease.Öğe Evaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Study(Korean Neuropsychiatric Assoc, 2019) Erbay, Mehmet Fatih; Zayman, Esra Porgali; Erbay, Lale Gonenir; Unal, SuheylaObjective Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study evaluated the antidepressant effect of rTMS and examined how it affected N-asetyl aspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), inyoinositol (mins), glutamate (Glu), glutathione (GSH), and glutamine (Gln) metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) of MDD patients who were not receiving antidepressant medication. Methods In total, 18 patients (10 female, 8 male) were evaluated. Each patient underwent H magnetic resonance spectroscopy (H-MRS) before and within 3 days of completion of TMS therapy. All patients completed 20 sessions of rTMS directed at the left DLPFC over a 2-week period. The Hamilton Depression Scale (HAMD) scores of patients were calculated, and their responses to treatment were assessed within 1-3 days of completion of TMS. Results We found statistically significant differences in HAMD scores before and after rTMS. Moreover, the peak metabolite ratios of NAA/Cr, GSH/Cr, and Gln/Cr were significantly higher after rTMS compared to those before rTMS. Conclusion Increased understanding of the mechanism of action of TMS will improve its application and may stimulate development of new generation therapeutic agents.Öğe Hepatik Ensefalopati(2023) Erbay, Mehmet FatihHepatik ensefalopati (HE) akut-kronik karaciğer yetmezliği ve/veya portosistemik şant nedenli ortaya çıka- bilen potansiyel olarak geri dönüşlü nörolojik disfonksiyon şeklinde tanımlanabilir. Tekrarlayan HE atakları kötü prognoz göstergesi olduğundan erken tanı ve hızlı tedavisi hayati önem taşır. En sık manyetik rezo- nans görüntüleme bulguları arasında simetrik globus pallidus ve substansia nigra T1 hiperintensitesi, akut dönemde perirolandik ve oksipital kortekslerin korunduğu yaygın kortikal şişme difüzyon kısıtlılığı ve aynı yerlerde FLAIR hiperintensite ile sulkal silinme sayılabilir.Öğe Insular volume reduction in young male schizophrenia patients(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2020) Erbay, Mehmet Fatih; Kartalci, SukruObjective: Recent developments in neuroimaging have advanced the understanding of biological mechanisms underlying schizophrenia. Structural and functional abnormalities of the insular cortex have been reported in schizophrenia patients. Many studies have demonstrated that insula volume is lower in schizophrenia patients than healthy individuals. The present study aimed to compare insula volumes of young male schizophrenia patients with that of age-matched young healthy male subjects to eliminate age and gender bias. Methods: Twenty-three male schizophrenia patients meeting DSM-5 diagnostic criteria, who were at the age of 18-40 years, and age-matched 25 healthy male subjects were included into the study. All patients magnetic resonance imaging (MRI) procedure was completed. Insula volume of schizophrenia patients and healthy male volunteers was calculated using MRICloud method. Disease severity was assessed using Positive and Negative Symptom Scale (PANSS). Results: Volumes of both the left and the right insula were significantly lower in the patient group vs. the control group. Moreover, a positive correlation was determined between the right insula volume and the scores of positive symptom severity scale. Conclusion: Decreased insular volume is not a specific marker, but it may be a general marker regarding psychopathology. However, investigating whether the diagnostic specificity of insular cortex abnormalities in psychopathologies will be the focus of future studies.Öğe İNTERNAL KAROTİS ARTER DİSEKSİYONU GELİŞEN BİR OLGUDA FİBROMUSKÜLER DİSPLAZİ: BİR OLGU SUNUMU(Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 2016) Erbay, Mehmet Fatih; Kamışlı, SuatÖz: Fibromusküler displazi, genellikle orta yaşlı kadınlarda prevalansı yüksek olan, idiopatik, noninflamatuar, nonaterosklerotik bir anjiopatidir. Hastalık, segmenter tutulum göstermekte olup, küçük ve orta çaplı arterlerin tüm tabakalarını etkileyebilir. Teorik olarak herhangi bir arteri tutabilmekle birlikte, en sık renal, karotid ve vertebral arterlerde görülür. Fibromusküler displazi, renal arter tutulumunda arteriyel hipertansiyon ile karotid ya da vertebral arterleri tuttuğunda ise iskemik inme veya geçici iskemik atak ile prezente olabilir. Vakaların çoğu asemptomatik olup tesadüfen tanı alırlar. Kesin tanısı klinik olarak ve dijital substraksiyon anjiografide "İpe dizilmiş tespih tanesi" görünümü ile konur. Bu tipik görünümün dışında daha az sıklıktaki görüntüleme bulguları arasında vasküler halkalar, fuziform vasküler ektazi, diseksiyon, anevrizma ve subaraknoid hemoraji yer alır. Özellikle genç hastalarda, daha az sıklıktaki bu radyolojik bulguların bilinmesi. fibromusküler displazi tanısında yardımcı olacaktır. Gençlerde fibromusküler displazi yüzünden internal karotid arterin diseksiyonu nadir bir geçici iskemik atak nedenidir. Bu olgu sunumunda, akut gelişen iskemik inme belirtileri nedeni ile değerlendirilirken, fibromusküler displazi saptanan genç bir bayan hasta üzerinden fibromusküler displaziye bağlı iskemik belirtiler ve antikoagülan tedaviye bakış tartışılacaktır.
