Yazar "Erdem, Fuat" seçeneğine göre listele

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  • Küçük Resim Yok
    Öğe
    Atipik klinik prezentasyonlu bir temporal arterit olgusu
    (2007) Kiki, İlhami; Gündoğdu, Mehmet; Erdem, Fuat; Sarı, Refik Ali
    Öz:Dev hücreli arterit olarak da bilinen temporal arterit, orta-büyük çaplı arterleri etkileyen enflamatuar bir hastalıktır. Her ne kadar birçok lokalizasyondaki arterleri etkileyebilen sistemik bir hastalık olsa da, karakteristik olarak başta temporal arter olmak üzere karotis arterinin bir veya daha fazla dalını tutar. Altmışbir yaşında erkek hasta kliniğimize baş ağrısı, şiddetli kulak çınlaması, halsizlik, terleme ve kilo kaybı şikayetleriyle başvurdu. Fizik muayenede bilateral submandibuler lenfadenopati ve hepatosplenomegali belirlendi. Temporal arter biyopsisinde “dev hücreli arterit (temporal arterit)” tanısı konuldu. Olgunun atipik prezentasyonu ve erken tanı ve tedavinin önemi nedeniyle sunmaya karar verdik.
  • Küçük Resim Yok
    Öğe
    Evaluation of Patients with PNH Treated By Eculizumab: Real World Data from Turkey
    (Amer Soc Hematology, 2019) Karadag, Fatma Keklik; Yenerel, Mustafa Nuri; Mehmet, Yilmaz; Teke, Hava Uskudar; Ozkocaman, Vildan; Tuglular, Tulin; Erdem, Fuat
    [Abstract Not Available]
  • Küçük Resim Yok
    Öğe
    Evolution of clinical characteristics of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab in turkey: a multicenter retrospective analysis
    (E-Century Publishing Corp, 2021) Karadag, Fatma Keklik; Yenerel, Mustafa Nuri; Yilmaz, Mehmet; Uskudar, Hava; Ozkocaman, Vildan; Tuglular, Tulin Firatli; Erdem, Fuat
    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare X-linked genetic disorder. On the contrary to its name, it is a multisystemic disease and various symptoms other than hemoglobinuria could be occurred. It could be life threatening especially because of thromboembolic events. In the last decade, a terminal complement inhibition with eculizumab approved with promising results for PNH patients. We conducted this study to evaluate the long term experience of eculizumab therapy from Turkey for the first time. Our cohort included 138 patients with PNH treated with eculizumab between January 2008 and December 2018 at 28 centers in Turkey. Laboratory and clinical findings at the time of diagnosis and after eculizumab therapy were recorded retrospectively. The median age was 39 (range 18-84) years and median granulocyte PNH clone size was 74% (range 3.06-99.84%) at the time of diagnosis. PNH with bone marrow failure syndrome was detected in 49 patients and the rest of 89 patients had classical PNH. Overall 45 patients (32.6%) had a history of any prior thrombotic event before eculizumab therapy and only 2 thrombotic events were reported during the study period. Most common symptoms are fatigue (75.3%), hemoglobinuria (18.1%), abdominal pain (15.2%) and dysphagia (7.9%). Although PNH is commonly related with coombs negativity, we detected coombs positivity in 2.17% of patients. Seven months after the therapy, increased hemoglobin level was seen and remarkably improvement of lactate dehydrogenase level during the treatment was occurred. In addition to previous studies, our real life data support that eculizumab is well tolerated with no serious adverse events and improves the PNH related findings.