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    Is Conservative Surgical Treatment Sufficient to Treat Unicystic Mural Ameloblastoma in Infant?
    (Lippincott Williams & Wilkins, 2015) Acar, Ahmet Huseyin; Yolcu, Umit; Erdem, Necip Fazil; Asutay, Fatih
    Ameloblastoma, a benign neoplasm derived from odontogenic epithelium, is an aggressive and locally invasive tumor. It represents 11% of all odontogenic tumors and 1% of all oral odontogenic epithelial tumors. In this case report, a 20-month-old boy was referred to our clinic with complaint of collapse in his symphysis region of the mandible. Radiographic examination revealed unilocular radiolucency in this region. The lesion was enucleated with 1 tooth germ under general anesthesia and diagnosed as mural unicystic ameloblastoma by histopathologic examination. After the surgery, complete healing was obtained clinically and radiographically. No sign of recurrence has been seen during the follow-up period of 4.5 years. To our knowledge, this was the second youngest case of ameloblastoma in the English literature. However, it is the youngest case of ameloblastoma that occurred in an infant boy.
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    Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium
    (Pergamon-Elsevier Science Ltd, 2015) Acar, Ahmet Huseyin; Yolcu, Umit; Gul, Mehmet; Keles, Ali; Erdem, Necip Fazil; Kahraman, Sevil Altundag
    Objective: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (beta TCP). Design: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PEP, Straumann (R) Bone Ceramic (SBC), or PEP + SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4(T-1) and 10 at week 8 (T-2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. Results: Histomorphometric and micro-CT analysis showed that both PEP and SBC significantly increased bone regeneration at T-1 and T-2 (P < 0.01). When PEP was used in combination with HA/beta TCP, a further significant increase in new bone formation was observed at T-1 and T-2 compared with that when PRF or SBC was used alone (P < 0.01). Conclusions: PRF has a positive effect on bone formation when used alone and in combination with HA/beta TCP. (C) 2014 Elsevier Ltd. All rights reserved.