Yazar "Erdogan, Mehmet Mustafa" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    Candidemia in adult intensive care units: Analysis of a 4 year process in a tertiary hospital in Turkey
    (2020) Erdogan, Esra; Erdogan, Mehmet Mustafa; Acun Delen, Leman
    Aim: Candidemia are one of the most important causes of mortality and morbidity in inpatients, and their importance is increasing with the increasing number of immunosuppressive patients and the widespread use of invasive procedures and broad spectrum antibiotics in recent years. In our study, we aimed to identify Candida species isolated from blood cultures and to determine the antifungal susceptibility rates of adult patients who were hospitalized in Malatya Education and Research Hospital Intensive Care Units between July 2015 and July 2019, and had Candida growth in at least one of their blood cultures.Materials and Methods: The blood cultures isolated from adult intensive care units patients and sent to the Microbiology Laboratory of our hospital over the four years, were examined retrospectively. Species distribution and antifungal susceptibility were determined using VITEK 2 Compact System (BioMerieux, France).Results: Of the 123 clinical samples, 59 (48%) were C. albicans, 21 (17.1%) were C. parapsilosis, 18 (14.6%) were C. tropicalis, 12 (9.8%) were C. glabrata, 5 (4.1%) were C. kefyr, 2 (1.6%) were C. krusei, 2 (1.6%) were C. lipoliytica, 2 (1.6%) were C. lusitaniae, 1 (0.8%) was C. dubliniensis and 1 (0.8%) was C. pelliculosa. 96.5% of C. glabrata strains were found to be susceptible to amphotericin-B, 93.1% to fluconazole, 98.3% to voriconazole, 93.5% to caspofungin, 91.4% to micafungin and 96.7% to flucytosine. 98.1% of nonalbicans Candida (NAC) strains were found to be susceptible to amphotericin-B, 74.6% to fluconazole, 90.7% to voriconazole, 78.4% to caspofungin, 80% to micafungin and 100% to flucytosine.Conclusion: The highest resistance to antifungals was found in C. glabrata and the highest susceptibility was observed in C. tropicalis. In order to develop effective and accurate infection control strategies and reduce mortality and morbidity, it is important to know the distribution and susceptibility of infectious agents, especially in critical patients in intensive care units.
  • Küçük Resim Yok
    Öğe
    Effect of Melatonin on Increasing the Effectiveness of Liver Preservation Solution
    (Aves, 2023) Erdogan, Mehmet Mustafa; Erdemli, Mehmet Erman; Ozhan, Onural; Erdemli, Zeynep; Bag, Harika Gozde Gozukara; Vardi, Nigar
    Background/Aims: Various tissue preservation solutions are used during the removal of the organ and during transplantation to protect the normal histological and biochemical characteristics of tissue while performing a successful liver transplant. In our study, it was aimed to investigate the effects of intraperitoneal melatonin administration on liver preservation damage before transplantation. Materials and Methods: In our study, the histological and biochemical characteristics of University of Wisconsin + melatonin group rats treated with melatonin 45 minutes before hepatectomy were compared between serum physiologic group and University of Wisconsin group. Results: When hematoxylin and eosin staining was evaluated in terms of hydropic degeneration, sinusoidal dilatation, and hepatocyte necrosis, there was no statistically significant difference. Caspase 3 immunohistochemical staining showed a significant increase in Caspase 3 immunoreactivity positivity at the 12th-hour University of Wisconsin group compared to University of Wisconsin + melatonin group. As a result of biochemical analysis, the malondialdehyde and total oxidant status levels in the University of Wisconsin + melatonin group decreased significantly compared to the University of Wisconsin group. When the reduced glutathione activity and total antioxidant capacity level were compared, a significant increase was observed in the University of Wisconsin + melatonin group compared to the University of Wisconsin group at the 12(th) hour. It was also found that aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels decreased significantly in the University of Wisconsin + melatonin 12(th)-hour group compared to the University of Wisconsin 12(th) hour and control group. Conclusion: When the findings were evaluated, intraperitoneal administration of melatonin, a cytoprotective antioxidant, was found to play an effective role in preserving immunohistochemical and biochemical properties of liver tissue integrity and hepatocytes in University of Wisconsin solution.
  • Küçük Resim Yok
    Öğe
    Hepatoprotective effects of N-acetylcysteine on liver injury by irisin upregulation and oxidative stress reduction in diabetic rats
    (Springeropen, 2023) Erdogan, Mehmet Mustafa; Erdogan, Mehmet Ali; Koc, Suleyman; Yalcin, Alper; Turk, Ahmet; Yetkin, Esra Akkus
    BackgroundThe current study aimed to investigate the oxidative stress in rat liver with diabetes mellitus (DM) as well as the protective effects of N-acetylcysteine (NAC) on irisin expression.MethodsTwenty-eight male Wistar rats were divided into four groups, 7 rats in each group, and 30-day regimens of experimental or control groups. NAC-treated group is as follows: 100 mg/kg once daily was administered intraperitoneally (i.p.). Diabetes-induced group is as follows: single-dose intraperitoneal injection of streptozotocin (STZ) (50 mg/kg) was used to induce DM in overnight fasting Wistar rats. By determining blood glucose concentration in STZ-induced rats 72 h after injection of STZ, DM was assessed. DM + NAC group is as follows: STZ-induced DM plus NAC is described previously. On the 30th day of the experiment, liver samples were collected after fasting and anesthesia. Biochemical analyses were performed to measure total antioxidant status (TAS), total oxidant status (TOS), and malondialdehyde (MDA) levels. Each liver sample was weighed and then prepared for histopathologic evaluation by light microscopy.ResultsThere was a statistically significant decrease in TAS levels and an increase in TOS and MDA levels in the DM group compared to the control group. In contrast, TOS and MDA levels were found significantly decreased, and TAS levels increased in the serum and liver tissues of the DM + NAC group compared to the DM group. Liver samples were also used for histopathological examination using hematoxylin-eosin and immunohistochemical staining. STZ-induced liver damage was detected as oxidative stress, increased irisin immunoreactivity, sinusoidal dilatation, and hepatocyte degeneration. In the DM + NAC group, it was observed that NAC significantly reduced the aforementioned histopathological changes due to STZ.ConclusionIn the early period of diabetes, due to the antioxidant properties of irisin related to the sudden response of liver tissue to oxidative stress, it is thought that the immunoreactivity in the tissue increases in the early period. As a result, NAC in diabetic rat liver tissue was found to suppress oxidative damage and irisin immunoreactivity.
  • Küçük Resim
    Öğe
    Seroprevalence of toxoplasmosis in women admitted to an education and research hospital in eastern anatolia after the syrian crisis
    (2020) Erdogan, Esra; Erdogan, Mehmet Mustafa; Altindag, Mehmet Murat
    Aim: Toxoplasmosis caused by Toxoplasma gondii, is a zoonotic disease which is generally asymptomatic. However, it causes serious symptoms in pregnant women and immunocompromised individuals. About one third of the people worldwide are seropositive. Due to the civil war in Syria, Turkey has been home to more than 4 million refugees. This unexpected increase in the Syrian population in particular increases the risk of infectious diseases. The aim of this study was to evaluate the prevalence of Toxoplasma gondii, antitoxoplasma IgG and IgM antibodies in local and Syrian women, who were admitted to Obstetrics and Gynecology Clinic of Malatya Education and Research Hospital, which is a tertiary care hospital in eastern part of Turkey, between January 2015 and July 2019.Material and Methods: The anti-toxoplasma IgG and anti-toxoplasma IgM antibody values of women who were admitted to our hospital and evaluated in terms of toxoplasma, determined by using “Chemiluminescence Immunoassay (CLIA)” method, were investigated retrospectively.Results: According to the results analyzed in a total of 11.025 women, including 743 Syrian refugees, the seropositivity of antitoxoplasma IgG and IgM were found to be 25.8% (2.819/10.932) and 1.6% (180/11.025), respectively. Among these patients, the seropositivity of anti-toxoplasma IgG was found to be 25.3% (190/750) and the seropositivity of anti-toxoplasma IgM was found to be 2.5% (20/797) in pregnant women. Anti toxoplasma IgG and IgM seropositivity were found to be 27.9% and 0.5%, respectively, in Syrian women. In Malatya, a city located in eastern Turkey, Toxoplasma gondii seropositivity was found to be common to the extent that it could not be neglected in both local women and Syrian refugees. No statistically significant difference could be found in Syrian female refugees living in Malatya in terms of carrying toxoplasma antibodies when compared with the local women. More than 70% of pregnant women were observed to be seronegative and they were at serious risk for toxoplasmosis. In particular, it was concluded that women at childbearing age, who constitute the risk group, should be made aware of the disease and serological tests should be performed routinely for toxoplasma.