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    Chemical Composition of the Essential Oil from Cupressus sempervirens L. horizontalis Resin in Conjunction with its Biological Assessment
    (Taylor & Francis Ltd, 2014) Ulukanli, Z. p; Karaborklu, S.; Ates, B.; Erdogan, S.; Cenet, M.; Karaaslan, M. G.
    Essential oil from the crude oleoresin of C. sempervirens L. was hydro-distillated and analysed by GC and GC-MS. The significant fraction of the essential oil constituted both monoterpene hydrocarbons (46.03 %) and oxygenated monoterpenes (17.27 %). The major components were mainly alpha-pinene (35.60 %), followed by trans-pinocarveol (5.22 %), alpha-phellandrene-8-ol (4.56 %), beta-pinene (3.06 %), D-limonene (2.83 %), borneol (2.34 %) and camphene (2.15 %). Antibacterial assays indicated the moderate level effectiveness on all tested gram positive and negative bacteria. The most sensitive bacteria were Staphylococcus aureus (ATCC 29213) and Staphylococcus aureus (ATCC 95923) followed by Micrococcus luteus (NRLL B-4375). Insecticidal activity of the essential oil exposure (48 h) on Ephestia kuehniella eggs showed 20.83 % mortality at 100 mu L L-1 air concentration. In the antioxidant assays, essential oil revealed a moderate level of the radical scavenging effect against DPPH and total phenolic content. Reducing power of the essential oil appeared to higher when compared to DPPH scavenging activity. Total phenolic content of the essential oil seemed to be well correlated with the assays of the DPPH and reducing power.
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    Effects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids: a peroxisomal perspective
    (Wiley, 2021) Otlu, H. G.; Ugur, Y.; Yildiz, A.; Erdogan, S.; Yologlu, S.; Vardi, N.; Guldur, T.
    [Abstract Not Available]
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    Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat
    (Springer London Ltd, 2013) Tasdemir, C.; Tasdemir, S.; Vardi, N.; Ates, B.; Onal, Y.; Erdogan, S.; Yucel, A.
    The aim of the study was to investigate the effect of ozone on oxidative/nitrosative stress and bladder injury caused by Escherichia coli in rat bladder. Twenty-one Wistar-Albino-type female rats included in the study were divided into three groups of equal number: (1) sham operation (control), (2) E. coli-only (EC), (3) EC + ozone. After ozone therapy for 3 days, urine and tissue samples were obtained for biochemical, microbiological, and histopathological analysis. Tissue malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) level were increased, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was decreased in the EC group. MDA, MPO, and NO levels were decreased, whereas SOD, GPx activity was increased in the ozone-treated group. Also, there was no bacterial translocation in this group. The results of the present study suggest that ozone may be used as an agent to protect the bladder from oxidative/nitrosative stress occurring in cystitis.
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    How safe is the use of herbal weight-loss products sold over the Internet?
    (Sage Publications Ltd, 2013) Ozdemir, B.; Sahin, I.; Kapucu, H.; Celbis, O.; Karakoc, Y.; Erdogan, S.; Onal, Y.
    Background: In recent years, the use of herbal weight-loss products sold over the Internet has rapidly increased; however, the safety of these products has not been well documented yet. More importantly, the declared ingredients in these products could be different than the marketed contents. Methods: Nine different herbal weight-loss products sold over the Internet were obtained. The ingredients of each product were analyzed in the Laboratory of Forensic Medicine and the Scientific and Technological Research Laboratory of Inonu University. Results: Although all studied weight-loss products were presented as pure herbal, three of them contain sibutramine, three contain caffeine, and three contain caffeine + temazepam. The amount of sibutramine in each capsule was found to be over 10 mg. We analyzed toxic and trace element levels of nine herbal products and found that these herbal products, even in low amounts, contain Pb, Al, Ni, and Ba. Conclusions: Our results indicate that herbal weight-loss products available without prescription and claimed to be purely herbal may contain pharmaceutical substances like sibutramine or temazepam in high doses. Moreover, they also may become contaminated with toxic metals. Since people commonly use these products unaware of its real constituents and without the suggestion or control of a physician, they might cause various health problems some of which might be harmful. Strict legal rules and control mechanisms must be established to minimize their possible harmful effects.