Yazar "Erdogan M.A." seçeneğine göre listele

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    Conduta anestésica em criança com osteogênese imperfeita e hemorragia epidural
    (Elsevier Editora Ltda, 2013) Erdogan M.A.; Sanli M.; Ersoy M.O.
    [No abstract available]
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    Efeitos antimicrobianos de cetamina em combinação com propofol: Um estudo in vitro
    (Elsevier Editora Ltda, 2013) Begec Z.; Yucel A.; Yakupogullari Y.; Erdogan M.A.; Duman Y.; Durmus M.; Ersoy M.O.
    [No abstract available]
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    of benign and malignant causes in patients undergoing endoscopic retrograde cholangiopancreatography for extrahepatic cholestasis
    (Verduci Editore s.r.l, 2023) Yildirim O.; Erdogan M.A.
    OBJECTIVE: Diagnosing benign vs. malignant extrahepatic cholestasis is challenging despite the currently available advanced imaging and endoscopic techniques. This study aims to determine the predictive accuracy of initial biochemical data and bile duct dilatation findings in transabdominal ultrasound (US) to differentiate between benign and malignant disease in patients with extrahepatic cholestasis. PATIENTS AND METHODS: We reviewed the case records of 814 patients who had undergone endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (in cases of unsuccessful ERCP) for extrahepatic cholestasis. The etiology of biliary obstruction was determined based on ERCP, endoscopic ultrasonography, radiology, cytology, biopsy, and/or clinical follow-up at one year. The patients were divided into benign and malignant groups according to the underlying etiology of biliary obstruction. A complete biochemical profile, transabdominal ultrasonography at presentation, and other demographic data were recorded. RESULTS: Alkaline phosphatase (p = 0.002), aspartate aminotransferase (p = 0.038), and bilirubin levels were significantly higher in malignant patients. The mean age of patients with malignancy was 69.5 years, vs. 60.6 years in benign patients (p < 0.001). The likelihood of malignancy increased with the increased bilirubin levels (> 200 µmol/l: 30.0% sensitivity, 97.6% specificity). The total bilirubin level predicting malignancy as the best cut-off value was 111 mmol/L with optimum sensitivity and specificity (61.8% and 83.8%, respectively) and area under the curve = 0.756, (p < 0.001). Intrahepatic bile duct (IHBD) dilatation was significantly higher in malignant patients (p < 0.001). CONCLUSIONS: A serum bilirubin level of 111 µmol/L or higher and the detection of IHBD dilatation on abdominal ultrasonography are important predictors in the differential diagnosis of benign and malignant causes of extrahepatic cholestasis. © 2023 Verduci Editore s.r.l. All rights reserved.
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    Protective effects of melatonin and ?-D-Glucan against liver injury in rats - A comparative study
    (Wroclaw University of Medicine, 2013) Aydogan M.S.; Erdogan M.A.; Polat A.; Yücel A.; Ozgül U.; Parlakpinar H.; Duran Z.R.
    Objectives. The aim of this study was to investigate the possible protective effects of melatonin and ?-D-glucan against ischemia-reperfusion (IR) injury in rats. Materials and Methods. Forty rats were randomly divided into 5 groups, each consisting of 8 animals, as follows. Sham group [S], IR group [C], IR + ?-Glucan group [?], IR + melatonin group [MLT], IR + melatonin + ?-Glucan group [MLT + ?]. The rats in the C, ?, MLT and MLT + ? groups were subjected to IR for 60 min each. Melatonin (10 mg·kg-1) was intraperitoneally injected for a single dose 30 min before IR. ?-Glucan (50 mg·kg-1·day -1) was orally administered for 10 days to rats. All of the rats were killed on day 11, and histological changes in the liver and tissue levels of oxidants and antioxidants were evaluated. Results. Malondialdehyde [MDA] level were significantly higher in the C group compared to the S group (p = 0.007). MDA level were significantly higher in the ? group compared to the MLT and MLT + ? groups (p =0.007). Tissue antioxidant markers (superoxide dismut ase [SOD], glutathione-peroxidase [GPx], and catalase [CAT]) were significantly lower in the C group than the S group (p < 0.05). SOD levels were simply not significant in the < group compared to the MLT and MLT + < groups. CAT and GPx activities were significantly higher in the ? group compared to the MLT and MLT + ? groups (p = 0.004).The histological damage ameliorated in ?, MLT and MLT + ? groups compared to C group. Conclusion. Our results suggest that melatonin and P-glucan combination pretreatment suppressed oxidative stress and increased antioxidant levels in an experimental rat model of liver IR injury. © Copyright by Wroclaw Medical University.