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    Clinicopathological analysis of seven breast hamartomas and review of the literature
    (2020) Kucukkosmanoglu, Ilknur; Eren Karanis, Meryem Ilkay; Altunkeser, Aysegul; Koksal, Hande
    Aim: Breast hamartomas are uncommon benign lesions that constitute 4.8% of benign breast tumors; they consist of mammary ducts and lobules, fatty tissue, and fibrous tissue. The aim of this study was to determine the clinical and pathological characteristics of breast hamartomas diagnosed by surgical resection and to examine the accompanying lesions. Material and Methods: Patients who underwent breast surgery between January 2013 and January 2018 at Konya Education and Research Hospital and who were diagnosed as having breast hamartomas were reviewed retrospectively. Results: Seven breast hamartomas were identified. All of them were female. The mean age was 45 years. The mean tumor size was 3.9 cm. Most of the lesions were located in the right breast (57.1%). All the hamartomas appeared in the upper part of the breast. Five of the seven cases were admitted with a painless palpable mass in the breast (71.4%). Three of the seven cases were myoid hamartomas. The type of lesion most commonly associated with breast hamartomas is cyst formation. Pseudoangiomatous stromal hyperplasia, columnar cell hyperplasia, and ductal epithelial hyperplasia are also common. Ductal epithelial hyperplasia and columnar cell hyperplasia were observed in all the myoid hamartomas. Ductal carcinoma in situ was detected in one case; it was also a myoid hamartoma. Conclusions: Breast hamartomas are accompanied by many types of lesions such as fibrocystic changes, adenosis, ductal epithelial hyperplasia, and pseudoangiomatous stromal hyperplasia. In addition to these lesions, columnar cell hyperplasia was also identified. Malignancies are rarely detected in breast hamartomas; however, one case of ductal carcinoma in situ in a myoid hamartoma was detected.
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    The importance of SUVmax in predicting prognosis of invasive breast carcinoma-no special types
    (2021) Eren Karanis, Meryem Ilkay; Erol, Mustafa; Unlu, Yasar
    Aim: We aimed to investigate the relationship between FDG uptake and clinicopathological characteristics of invasive breast carcinoma-no special type in the present study.Materials and Methods: One hundred seventy invasive breast carcinoma-no special type cases who underwent PET-CT before surgery between 2011-2019 were included in the study. The clinicopathological features and SUVmax of the patients were compared.Results: We observed a strong relationship between the size, grade, pathological stage groups and SUVmax of the tumors and revealed that the SUVmax increased as the size, grade, and pathological stage groups of the tumors increased (p0.001). Carcinomas with high Ki67 proliferation index and ER and PR negative carcinomas exhibited higher SUVmax (p0.001). Triple negative and HER2-enriched molecular subtypes had distinctly higher SUVmax than Luminal A and Luminal B ones (p0.001). HER2-enriched tumors, the cases that were 40 years old and advanced stage designated higher SUVmax (p0.05). Conclusion: It is observed that invasive breast carcinoma-no special type with good prognostic factors have low SUVmax, while carcinomas with poor prognostic features have high SUVmax. It can be suggested that PET/CT can be use to predict the prognosis of invasive breast carcinoma-no special type.