Yazar "Erkal, Haldun S." seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Evaluation of protective effects of verapamil against lens epithelial tissue injury induced by irradiation in rats
    (Turkish Journal of Pharmaceutical Sciences, 2010) Batçıoğlu, Kadir; Erkal, Haldun S.; Serin, Meltem; Uyumlu, A. Burçin; Yücel, Neslihan; Yıldırım, Battal; Satılmış, Basri
    Öz: Bu çalsmada, ratlarda radyasyonla indüklenen lens epitel hücre hasarna karsi verapamilin olası koruyucu etkisini inceledik. Kırk adet dişi Wistar Albino türü rat dört guruba ayrıldı (n=10). Gurup 1’e 20 Gy dozda radyasyon ve 10 mg/kg verapamil uygulandı. Gurup 2’ye 20 Gy radyasyon uygulandı ve verapamil verilmedi. Gurup 3’e 10 mg/kg dozda verapamil verildi, yalancı radyasyon uygulandı. Gurup 4’e verapamil verilmedi ve yalancı radyasyon uygulandı. Tüm guruplarda lens dokular ç ikarldı ve malondialdehit (MDA) ölçümleri yapıldı. Ortalama MDA düzeyleri (nmol/mg prt); Gurup 1 için 5.59, Gurup 2 için 7.04, Gurup 3 için 3.95 ve Gurup 4 için 3.25 olarak belirlendi. Sonuç olarak, radyasyonla indüklenen lens epitel hücre hasarna karsi verapamili koruyucu bir ajan olarak önerebiliriz.
  • Küçük Resim Yok
    Öğe
    Histopathological Evaluation of the Effects of Melatonin as a Protectant Against Oropharyngeal Mucositis Induced by Radiation Therapy in a Pinealectomy Model in Rats
    (Akad Doktorlar Yayinevi, 2009) Ozturk, Aysen S.; Erkal, Haldun S.; Memis, Leyla; Oztanir, Namik; Ersoy, Eren; Aykol, Suekrue; Egehan, Ibrahim
    This study presents the histopathological evaluation of the effects of melatonin as a protectant against oropharyngeal mucositis induced by radiation therapy in a pinealectomy model in rats. Thirty-two Wistar rats were divided into four groups. The rats in Group 1 underwent pinealectomy, received melatonin and underwent radiation therapy. The rats in Group 2 underwent pinealectomy, received no melatonin and underwent radiation therapy. The rats in Group 3 underwent sham pinealectomy, received melatonin and underwent radiation therapy. The rats in Group 4 underwent sham pinealectomy, received no melatonin and underwent radiation therapy. The rats underwent euthanasia at six days following radiation therapy. The oropharyngeal tissues were dissected and histopathological evaluation was performed regarding the effects of melatonin as a protectant against oropharyngeal mucositis induced by radiation therapy. Mean item scores for vascular calibration were 2.3 points for Group 1, 2.3 points for Group 2, 1.8 points for Group 3 and 2.1 points for Group 4 (p= 0.44). Mean item scores for vascular permeability were 2.4 points for Group 1, 2.4 points for Group 2, 2.0 points for Group 3 and 2.1 points for Group 4 (p= 0.61). Mean item scores for leukocyte emigration were 2.0 points for Group 1, 2.0 points for Group 2, 1.3 points for Group 3 and 1.6 points for Group 4 (p= 0.02). Mean overall scores for oropharyngeal mucositis were 6.6 points for Group 1, 6.6 points for Group 2, 5.1 points for Group 3 and 5.8 points for Group 4 (p= 0.15). This study elicits the potential effects of melatonin as a protectant against oropharyngeal mucositis induced by radiation therapy.