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Öğe The effect of HA330 hemoperfusion adsorbent method on inflammatory markers and end-organ damage levels in sepsis: a retrospective single center study(Verduci Publisher, 2022) Erkurt, M. A.; Sarici, A.; Ozer, A. B.; Kuku, I; Bicim, S.; Aydogan, M. S.; Kose, A.OBJECTIVE: In this study, we aimed at evaluating the impact of HA330 hemoperfusion adsorbent application on inflammatory markers and end-organ damage markers in patients with sepsis/septic shock. PATIENTS AND METHODS: Patients who were diagnosed with sepsis/septic shock and treated with HA330 hemoperfusion adsorbent in addition to the standard treatment were included in this retrospective study conducted at Inonu University Turgut Ozal Medical Center between January 1, 2019 and January 1, 2021. RESULTS: A total of 150 patients were included in the study. The mean +/- SD age of the patients was 51.9 +/- 17.7 years. 102 patients (68%) were in septic shock. Mean +/- SD APACHE II scores were 15.3 +/- 4.8. The need for mechanical ventilation was noted in 64 patients (42.7%). WBC, neutrophil count, hemoglobin, platelet count, BUN, creatinine, AST, ALT, CRP and procalcitonin levels were measured before and after the procedure. Overall, 104 patients (69.3%) died median (min-max) 2.5 (1-114) days after the cytokine adsorption, while 46 patients (30.7%) recovered from sepsis and were discharged. The increase in BUN levels and decrease in platelet count after the procedure were statistically significant ( p= 0.001, 0.041, respectively) in the overall study population. The laboratory findings in 46 survivors indicated significantly decreased AST and ALT levels after cytokine adsorption compared to baseline pre-treatment levels. WBC, neutrophil count, CRP, procalcitonin, BUN and creatinine values were also decreased after cytokine adsorption in survivors, whereas the change was not statistically significant. There was also a non-significant tendency for an increase in platelet count and hemoglobin levels after cytokine adsorption compared to pre-treatment values in these patients. CONCLUSIONS: Although no effect of HA330 hemoperfusion application on inflammatory markers and end- organ damage markers was demonstrated in our study, we used the HA330 hemoperfusion adsorbent method as a last resort in terminal patients with a mortality rate of approximately 90% and for whom antibiotic treatment did not benefit. Therefore, multicenter, prospective studies are needed to clarify the effect of early HA330 hemoperfusion use in the treatment of sepsis.Öğe Mapping of Blood Coagulation via Image Processing Method(Ieee, 2015) Onar, B.; Bayindir, M. I.; Bilgili, H.; Erkurt, M. A.; Yakinci, C.; Yakinci, M. E.Biomedical applications based on image process algorithms are developed to aid doctors for diagnostic of some diseases. Several conventional tests are available about measuring blood coagulation such as PTZ, aPTZ, PTZ-INR. These tests are performed before every surgical operation even during some critical operations especially in cardiovascular and liver operations. Then, images are taken by a microscope connected to a computer in every 15 seconds, in such a way that 45 images are obtained till end of coagulation. These images are processed in an image processing algorithm in Matlab software. Hence, a graphical representation is produced for every subject. Results obtained from the proposed method prove that it can be a useful alternative to conventional methods.Öğe The outcome of eltrombopag therapy in immune thrombocytopenia: a multicenter study from Turkey(Wiley-Blackwell, 2016) Pamuk, G. E.; Maden, M.; Sari, H., I; Erkurt, M. A.; Keskinkilic, M.; Cagliyan, Akgun G.; Kaya, A. H.[Abstract Not Available]Öğe THE TROUBLE THAT HEMATOLOGISTS DEALING WITH: VARICELLA-ZOSTER AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION(Ferrata Storti Foundation, 2016) Ozkan, M. Comert; Ozen, I. Nizam; Dolasik, I.; Kaya, E.; Erkurt, M. A.; Kuku, I.[Abstract Not Available]
