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  • Küçük Resim
    Öğe
    Correlation of central corneal thickness with central macular thickness in premature infants
    (2018) Dogan, Berna; Erol, Muhammet Kazim
    Aim: To evaluate the relationship between the central corneal thickness (CCT) and central macular thickness (CMT) in premature infants. Material and Methods: All infants with a birth weight of less than 2.500 g or with a gestation period of less than 36 weeks were included in the study. Data including birth week, birth weight, age, and body weight at the time of imaging, and weight gain were recorded. The central, superior, nasal, temporal, and inferior macular and corneal thicknesses were measured using the spectraldomain optical coherence tomography (SD-OCT). The correlation between macular and corneal thicknesses and multiple factors including birth week, birth weight, age, and body weight at the time of imaging, and weight gain were analyzed. Results: A total of 74 premature infants were included in the study. The mean birth week and birth weight were 30.5±2.8 weeks and 1520.3±495.3 g, respectively. There were significant positive correlations between the central macular thicknesses and the central (p=0.036, r=0.246), superior (p=0.019, r=0.273), nasal (p=0.035, r=0.248), and inferior (p=0.041, r=0.240) corneal thicknesses. There were significant negative correlations between the central (p=0.021, r=-0.378), superior (p=0.044, r=-0.334), nasal (p=0.002, r=- 0.491), inferior (p=0.001, r=-0.526), temporal (p=0.018, r=-0.387) corneal thicknesses and age at the time of imaging. Conclusion: Our study results suggest that there were significant and positive correlations of the central macular thicknesses with the central, superior, nasal and inferior corneal thicknesses. Corneal thickness was significantly negative correlated with age at the time of imaging.
  • Küçük Resim
    Öğe
    Spectral domain-optical coherence tomographic assessment of macular changes following anti-vascular endothelial growth factor therapy in patients with retinopathy of prematurity
    (2018) Toslak, Devrim; Erol, Muhammet Kazim
    Aim: The purpose of this study was to investigate the effect of intravitreal ranibizumab (IVR) injection for type 1 and aggressive posterior retinopathy of prematurity (ROP) and to detect probable alterations in central foveal thickness, to analyze macular structural changes and to observe regression of ROP following IVR therapy. Material and Methods: 40 eyes of 22 patients with type 1 or aggressive posterior ROP who received IVR injections and had macular spectral domain– optical coherence tomography (SD – OCT) images were included in the study. All eyes were scanned using a portable SD-OCT machine before treatment and 1st week, 1st month, 2nd month following IVR injection. All SD-OCT images were evaluated for central foveal thickness (CFT) and the development of cystoid macular edema (CME). Results: Recurrence of plus disease was observed in 10 eyes of six patients after IVR injection. Interval time from initial injection to recurrence was between 7 and 10 weeks. Alterations in CFT and macular structure were observed in short term period following IVR injection for type I and APROP. CME was observed in all patients but at various times in their follow-up periods. Conclusions: CME is a frequently seen finding in type I ROP and APROP. It might be a physiologic consequence of normal development of macula as well as part of pathologic process influenced by IVR injection. Even though recurrence rate of ranibizumab is higher than bevacizumab, we propose that ranibizumab may be a safer alternative agent than bevacizumab.