Yazar "Ersoy, Alevtina" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Platelet Activity Increases in Patients with Diabetic Retinopathy
    (2022) Siranli, Gulsah; Mertoğlu, Cuma; Ersoy, Alevtina; Karakurt, Yücel; Ozcicek, Adalet; Çoban, Abdulkadir
    Objective: The role of new inflammatory markers such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, mean platelet volume, and platelet distribution width in diabetic microvascular complications was investigated. Methods: A total of 266 (172 female, 94 male) individuals were divided into 5 groups: group 1, who have diabetes without any complications for at least 10 years; group 2, only diabetic nephropathy; group 3, only diabetic neuropathy; group 4, only diabetic retinopathy; and group 5, control group. Results: Glucose and HbA1c were higher in retinopathy, neuropa thy, and nephropathy groups than in the control group (P < .001). Neutrophil-lymphocyte ratio in the neuropathy group was higher in the retinopathy and uncomplicated diabetic groups (mean ± SD; 2.4 ± 2.9, 1.6 ± 0.5, 1.5 ± 0.5, P = .018, P = .001, respectively), and platelet-lymphocyte ratio was higher only in the retinopa thy group (mean ± SD; 133.8 ± 59, 105.5 ± 34, P = .001). In the retinopathy group, mean platelet volume and platelet distribution width were higher than the control group and the uncomplicated diabetic group (mean platelet volume mean ± SD; 10.6 ± 1.0, 10.0 ± 0.6, 9.7 ± 1.9, P = .009, P = .003, platelet distribution width mean ± SD; 13.0 ± 2.3, 11.4 ± 1.2, 11.7 ± 1.6, P < .001, P = .003, respec tively). Conclusions: Patients with diabetic neuropathy have sub clinical inflammation, and patients with retinopathy have platelet activation. However, further studies are needed to investigate the mechanism of this increased inflammation and platelet reactivity in the development of these complications.
  • Küçük Resim Yok
    Öğe
    The role of protein oxidation in the development of diabetic microvascular complications
    (Kare Publ, 2021) Mertoglu, Cuma; Siranli, Gulsah; Coban, T. Abdulkadir; Karakurt, Yucel; Ersoy, Alevtina; Ozcicek, Adalet; Arslan, Yusuf
    OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.