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    Comparison of prosthetic materials used for abdominal wall defects or hernias (an experimental study).
    (1995) Sahin M.; Hasanoglu A.; Erbilen M.; Orakçi V.; Bülbüloglu E.; Ertaş E.
    The prosthetic materials polypropylene and polytetrafluoroethylene were comparatively studied for postinterventional infection, development of adhesions, and recurrence of hernias and tissue reactions in rats in which abdominal defects 1 by 2 cm in size had been repaired with one of these materials. As regards infection and hernias there was no significant difference vs. a control group of rats. There was no collagen deposition in polytetrafluoroethylene, and the mononuclear inflammatory cell reaction and fibroblastic activity outside the graft layer were steadily less intense with polytetrafluoroethylene than with polypropylene. Adhesions were significantly (p < 0.05) more marked with polypropylene.
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    Effect of nitric oxide on bacterial translocation in experimental intestinal obstruction
    (Turkish Surgical Society, 2001) Hasano?lu A.; Karadaş K.; Türköz Y.; Özerol I.H.; Tekereko?lu M.S.; Aydin N.E.; Ertaş E.
    Bacterial translocation is defined as the passage of endogenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs that suggested to be the cause of sepsis in patient with multiple organ failure. The aim of this study was to investigate the antibacterial effect of nitric oxide by using nitric oxide synthetase enzyme inhibitors such as L-NAME and aminoguanidin in the obstructive intestinal rat model. Fourty rats were divided into four groups. The first one was control group and had only laparatomy. Intestinal obstruction was performed to second group, intestinal obstruction + L-NAME (L-NG-nitro-L-arginine methyl ester) were applied to third group. Fourth group had intestinal obstruction and aminoguanidin was injected to them. According to the histopathological study of the intestine, group III demonstrated less ulceration than groups II and IV (p<0.05). Mucosal damage and bacterial translocation showed no correlation according to the results. The incidence of bacterial translocation was 46.6% in group II, 73.3% in group III and 90% in group IV. Eighty two percent of isolated bacteria was typical enteric Gram negative organisms. Bacterial translocation was not observed in control group. Plasma nitric oxide levels of groups were 14.0±3.3, 31.2±7.6, 12.2±2.5, and 10.5±1.8 ?mol/L, respectively. As a conclusion; nitric oxide can damage mucosal integrity that may increase bacterial translocation but the antibacterial effect of nitric oxide may be more effective and nitric oxide can decrease the translocation of bacteria from gut.