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  • Küçük Resim
    Öğe
    Clinical characteristics and treatments outcomes in elderly patients with multiple myeloma: A multicenter retrospective study
    (2017) Terzi, Hatice; Korkmaz, Serdal; Berber, İlhami; Keklik, Muzaffer; Doğu, Mehmet Hilmi; Şencan, Mehmet; Kaya, Emin; Eser, Bülent; Sarı, İsmail; İlhan, Osman
    Abstract: Amaç: Mutipl Myeloma, tüm kanser tiplerinin %1' ini, hematolojik malignitelerin ise %10' unu oluşturan tamamen kürün sağlanamadığı fatal bir hastalıktır. Genellikle yaşlı populasyonda izlenir. Bu çalışmanın amacı, son 5 yılda farklı rejimlerle tedavi edilen 65 yaş ve üzerindeki 105 Mutipl Myeloma' lı hastadaki klinik deneyimimizi sunmaktır. Yöntem: 65 yaş üzerindeki Mutipl Myeloma'lı hastaların klinik karakterleri ve terapötik sonuçlarını analize etmek için, Türkiye'deki 5 farklı merkezden retrospektif olarak veriler toplandı.Bulgular: 51 erkek ve 54 kadından oluşan toplam 105 yaşlı Multipl Myeloma hastası (65 yaş ve üzeri) retrospektif olarak değerlendirildi. Hastalara ilk basamak olarak, VAD( vinkrsitin, adriamisin, deksametazon), VCD ( Bortezomib, siklofosfamid, deksametazon), MP( melphalan, prednizolon), MPT (Melphalan, prednizolon, thalidomid) rejimleri verildi. 29 hastada tam yanıt elde edildi ve bu hastaların 18 'ine otolog kök hücre nakli yapıldı. Tam yanıt elde edilemeyen 46 hastaya, ikinci basamak tedavi olarak bortezomib, lenalidomid ve talidomid bazlı rejimler verildi. İkinci basamak tedavi ile tedavi edilenlerin 29'unda tam yanıt elde edildi ve bu hastalardan 20'sine otolog kök hücre nakli yapıldı. 16 hastaya ise birinci ve ikinci basamak rejimlere yanıt vermediğinden lenalidomid bazlı rejimler (n: 10), talidomid bazlı rejimler (n: 6) verildi. Bu tedavilerle remisyona giren 5 hastaya Otolog kök hücre nakli yapıldı. Sonuç: Optimal tedavi yaklaşımı, verimli, güvenli, kaliteli yaşam sağlamalı ve amaç tam yanıtın yanı sıra hastalıksız sağ kalımı ve genel sağ kalımı uzatmak olmalıdır
  • Küçük Resim
    Öğe
    Phenotype frequencies of blood group systems and alloantibodies to red blood cells in blood transfusion recipients in Kayseri (Turkey)
    (2017) Altuner Torun, Yasemin; Kaynar, Leylagül; Karakukcu, Cigdem; Yay, Mehmet; Ergul, Ayse Betul; Turanoglu, Cem; Cetin, Mustafa; Eser, Bülent
    Aim: In this study, we aimed to asses the antigen and phenotype frequencies of various blood groups among recipients of erythrocyte suspensions in Kayseri. Material and Methods: The study was conducted as retrospective, cross sectional and multicenter study. In all, 48750 blood recipients old typed in terms of the ABO, Rh, MNS, Duffy, Lewis, P, Kell, Lutheran, and Kidd systems were subjected to erythrocyte phenotyping using a gel centrifugation method within the age group of 18-60 years. Results: Of the ABO blood group, A was most frequent (44%) followed by O, B, and AB (30.3%, 16.2%, and 6.5%, respectively). The frequencies of Rh antigens were 88% D-positive and 12% D-negative. Alloantibodies were detected by screening in 196 (0.4%) of 48,750 patients, and decreased in the order anti-E (62%), -C (43%), -D (42%), -C (11%), -c (11%), -e (8%), -M (7%), -Fy a (5%), -Jk a (5%), -Kp a (4%), -Le a (3%), -Jk b (2%) ,-S (2%), -Le b (1%), and -P (1%). The most frequently detected alloantibodies were anti-E (31.6%) and -K (21.9%). Conclusion: Knowledge of the phenotypic frequencies of red blood cell antigens allows the creation of banks of appropriate antigennegative blood, thus preventing transfusion reactions in patients requiring multiple transfusions or who express alloantibodies.
  • Küçük Resim
    Öğe
    Phenotype frequencies of blood group systems and alloantibodies to red blood cells in blood transfusion recipients in Kayseri (Turkey)
    (2017) Torun Altuner, Yasemin; Kaynar, Leylagül; Karakükcü, Çiğdem; Yay, Mehmet; Ergül, Ayşe Betül; Turanoğlu, Cem; Çetin, Mustafa; Eser, Bülent
    Abstract:Aim: In this study, we aimed to asses the antigen and phenotype frequencies of various blood groups among recipients of erythrocyte suspensions in Kayseri. Material and Methods: The study was conducted as retrospective, cross sectional and multicenter study. In all, 48750 blood recipients old typed in terms of the ABO, Rh, MNS, Duffy, Lewis, P, Kell, Lutheran, and Kidd systems were subjected to erythrocyte phenotyping using a gel centrifugation method within the age group of 18-60 years. Results: Of the ABO blood group, A was most frequent (44%) followed by O, B, and AB (30.3%, 16.2%, and 6.5%, respectively). The frequencies of Rh antigens were 88% D-positive and 12% D-negative. Alloantibodies were detected by screening in 196 (0.4%) of 48,750 patients, and decreased in the order anti-E (62%), -C (43%), -D (42%), -C (11%), -c (11%), -e (8%), -M (7%), -Fy a (5%), -Jk a (5%), -Kp a (4%), -Le a (3%), -Jk b (2%) ,-S (2%), -Le b (1%), and -P (1%). The most frequently detected alloantibodies were anti-E (31.6%) and -K (21.9%). Conclusion: Knowledge of the phenotypic frequencies of red blood cell antigens allows the creation of banks of appropriate antigen- negative blood, thus preventing transfusion reactions in patients requiring multiple transfusions or who express alloantibodies.
  • Küçük Resim
    Öğe
    Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study
    (2020) Okay, Müfide; Aslan, Tuncay; Özdemir, Evren; Üner, Ayşegül; Ayhan, Arzu; Güngör, Elif Sena; Uysal, Ayşe; Alayvaz, Nevin; Yıldızhan, Esra; Ağıt, Abdullah; Dal, Mehmet Sinan; Korkmaz, Serdal; Namdaroğlu, Sinem; Sivgin, Serdar; Akgün Çağlıyan, Gülsüm; Demircioğlu, Sinan; Barışta, İbrahim; Özhamam, Esra; Vural, Filiz; Eser, Bülent; Özet, Gülsüm; Yıldırım, Rahşan; Doğu, Mehmet; Berber, İlhami; Erkurt, Mehmet Ali; Malkan, Ümi?T Yavuz; Altuntaş, Fevzi; Büyükaşık, Yahya
    Abstract: Objective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from North America and Europe, and data from other countries are insufficient. In this multicenter study we aimed to identify the clinical characteristics of SMZL patients in Turkey, including viral hepatitis status and treatment details. Materials and Methods: Data were gathered from participating centers from different regions of Turkey using IBM SPSS Statistics 23 for Windows. Hepatitis B virus surface antigen (HBsAg), anti-HBs antibody, anti-HB core antigen antibody (anti-HBcAg), HB viral load, anti-hepatitis C virus (HCV) antibody, HCV viral load results were analyzed. Results: One hundred and four patients were reported. Hepatitis C virus positivity was observed in only one patient. However, hepatitis B virus surface antigen (HBsAg) positivity was observed in 11.2% and HBsAg and/or anti-HB core antigen antibody (anti-HBcAg) positivities were seen in 34.2% of the patients. The median age was 60 years (range=35-87). Median follow-up duration was 21.2 months (range=00.2-212; 23.2 months for surviving patients). Median overall survival was not reached. Estimated 3-year and 10-year survival rates were 84.8% and 68.9%, respectively. Older age, no splenectomy during follow-up, platelet count of <90x103/µL, lower albumin, higher lactate dehydrogenase, higher ?2-microglobulin, and HBsAg positivity were associated with increased risk of death. Only albumin remained significant in multivariable analysis. Conclusion: These results indicate that hepatitis B virus may be a possible risk factor for SMZL in our population. It may also be an indirect prognostic factor.