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Öğe Is mean platelet volume a predictor of atherosclerosis in hemodialysis patients?(2017) Yayar, Özlem; Eser, Baris; Bicakci, Fahrettin; Ayli, Mehmet DenizAim: Cardiovascular (CV) mortality accounts for the 45% of all mortality in dialysis. Carotid intima-media thickness (CIMT) is a preclinical marker for CV disease. Activated platelets pose important part of the cellular component in the pathophysiology of atherothrombosis. Mean platelet volume (MPV) is a parameter that indicates the activation of platelets and assessed by studies in various patient groups in atherosclerosis. The aim of this study is to determine the relation of MPV with CIMT in haemodialysis (HD) patients without a history of atherosclerosis. Material and Methods: Eighty two HD patients and 20 healthy individuals were enrolled in this cross-sectional study. Ultrasonographical B-mode imaging of bilateral carotid arteries was performed with a high resolution real-time ultrasonography with 12MHz linearassay transducer (Mindray DC7). The value was expressed as an average of the maximal CIMT. MPV was measured by automated devices. Results: CIMT was found to be higher in study population when compared to control group. MPV was not different between groups (8.40±0.85 vs 8.4±0.81; P>0.05). In correlation analysis CIMT was found to be positively correlated with age(r=0.326; P=0.003), ALP(r=0.309; P=0.005) and MPV(r=0.26; p= 0,017). Patients were grouped according to median levels of MPV. The patients having higher MPV values were found to have higher PTH (533.9 ± 458.3 vs 845.8 ± 860.2; P<0, 05) and CIMT (0.8 ± 0.1 vs 0.9 ± 0.2; P<0. 05) values. Conclusions: MPV was found to be correlated with CIMT in HD patients. MPV can be used as a marker in HD patients for determining atherosclerosis.Öğe Relationship between peritoneal permeability with inflammation and subclinical atherosclerosis in peritoneal dialysis patients(2018) Yayar, Özlem; Eser, Baris; Bozkurt, AlperAim: High permeability in peritoneal dialysis (PD) is reported to be associated with increased mortality. Cardiovascular disease is the most important cause of morbidity and mortality in patients with end-stage renal disease. The inflammation is thought to take part in development of atherosclerosis. The aim of this study is to investigate the relation of peritoneal permeability type with carotid intima media thickness (CIMT) in PD patients. Material and Methods: Based on the standard peritoneal equilibration test, 56 PD patients (28 male) were divided in two transporter groups: low (low+low average) and high (high+high average) permeability. C-reactive protein (CRP) measured as a marker of inflammation and CIMT was evaluated by high-resolution B-mode ultrasonography. Results: Twenty one patients were low and 35 of them were high peritoneal transporters. Mean CRP level was significantly higher in the high permeability group (HPG) (1.62±1.7 vs 0.84±1 mg/dL; p=0.006). CIMT was higher in the HPG but this difference did not reach statistical significance (0.810±0.160 vs 0.740±0.160 mm; p=0.16). Conclusions: CRP, an indicator of inflammation, was found to be higher in the HPG. CIMT also was found to be higher in HPG although it was not statistically significant. One of the causes of increased mortality rate in this group of patients may be explained by inflammation and atherosclerosis.