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    The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study
    (Int Scientific Information, Inc, 2019) Yilmaz, Ercan; Gurocak, Simay; Melekoglu, Rauf; Koleli, Isil; Faydali, Simge; Temelli, Oztun; Yar, Tuba
    Background: This retrospective clinical study aimed to investigate the effect of prognostic factors and adjuvant radiotherapy in patients with high-grade early-stage endometrial cancer on overall survival (OS) and disease-free survival (DES). Material/Methods: The medical records of patients diagnosed with high-grade, early stage (I or II) endometrial adenocarcinoma who had received adjuvant radiotherapy after surgery were reviewed. Results: Seventy-nine patients included 39 patients (49.4%) with stage II endometrial cancer, 25 patients (31.6%) with histologic grade 3 tumors, and 47 patients (59.5%) with endometrial cancer showing lymphovascular space invasion (LVSI). There were 45 patients (57.0%) who received external pelvic radiotherapy with an average dose of 46.0 Gy (range, 11.2-50.4 Gy), and 34 patients (43.0%) received vaginal brachytherapy (VBT) with an average dose of 21.5 Gy (range, 10-36 Gy). Multivariate analysis showed that tumor stage (HR, 4.066; 95% CI, 1.227-13.467; p=0.022) and histologic grade (HR, 16.652; 95% CI, 4.430-62.589; p<0.001) were independent predictors for OS. Increased serum CA-125 levels (HR, 1.136; 95% CI, 0.995-1.653; p=0.047) and histologic grade (HR, 3.236; 95% CI, 1.107-15.156; p=0.015) were independent predictors for DES. Adjuvant radiotherapy was not found to be significantly associated with improved OS (HR, 1.259; 95% CI, 0.518-3.058; p=0.612) or DES (HR, 1.056; 95% CI, 0.994-1.123; p=0.078). Conclusions: This retrospective study showed that in high-grade early-stage endometrial cancer treated with postoperative adjuvant radiotherapy, independent predictors for OS were tumor stage and grade. Adjuvant radiotherapy was not associated with improved OS or DES.
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    Primary endometrial and cervical squamous cell carcinoma in situ, a rare coexistence: case report and literature review
    (7847050 Canada Inc, 2019) Yilmaz, Ercan; Alan, Saadet; Faydali, Simge; Melekoglu, Rauf; Gokce, Hasan; Kural, Hasim
    Although the most common gynecologic tumor of the female genital system is endometrial adenocarcinoma, endometrial squamous cell carcinoma (ESCC) is rarely seen. The presence of ESCC is commonly known as a concomitant tumor secondary to cervical squamous cell carcinoma (SCC). However primary endometrial squamous cell carcinoma (PESCC) is a more rare tumor type. In situ carcinoma, defined as the inflammation of entire intraepithelial tissue with dysplastic cells without identifying any concomitant invasion or metastasis, is considered to be among the precancerous lesions of the female genital system. In situ squamous cell carcinoma cases, especially identified in the cervical region, can be rarely observed in the endometrial tissue. In this case report, the authors aimed to discuss a case of cervical and ESCC in situ which is reported for the first time in the literature.
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    RETROSPECTIVE ANALYSIS OF BORDERLINE OVARIAN TUMORS: OUTCOMES AT A SINGLE CENTER
    (Sestre Milosrdnice Univ Hospital, 2019) Yilmaz, Ercan; Sahin, Nurhan; Koleli, Isil; Melekoglu, Rauf; Tanrikut, Emrullah; Faydali, Simge; Karaer, Abdullah
    We wanted to discuss our experiences in the approach to borderline ovarian tumors, which constitute a group different from epithelial ovarian tumors with respect to their biological structure in line with retrospective information gathered from our cases. A total of 25 patients operated on for the indication of adnexal masses diagnosed as borderline ovarian tumors based on frozen section results were included in our study. Patient age, tumor diameter, tumor markers and surgeries performed were discussed in the light of the literature. Statistical analyses were performed using the SPSS software. The patient mean age was 43.84 +/- 11.34 years. The mass was localized in the right (n=13), left (n=11) or both (n=1) adnexal regions. The mean tumor diameter was 12.9 +/- 5.84 cm. Histopathologic examination established the diagnosis of serous borderline (n=14 patients) and mucinous borderline (n=11) ovarian tumors. Although the results of our study are consistent with current literature data, a greater number of current studies should be performed on borderline ovarian tumors, which are defined as a class of tumors different from epithelial ovarian tumors.