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Öğe Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model(Univ Puerto Rico Medical Sciences Campus, 2024) Aydin, Muhammed Ali; Aydogdu, Nurettin; Tastekin, Ebru; Firat, Nihayet; Yavuz, Ozlem YalcinkayaObjective: Hypertension is one of the cardiovascular diseases that causes the most mortality, and 95% of the causes are unknown. The aim of the study was to examine the possible correlation of nesfatin-1 levels, adropin levels, claudin-2 immunoreactivity (claudin-2 expression in the renal proximal tubule), and renalase immunoreactivity (renalase expression in the renal proximal tubule) with arterial blood pressure, kidney function, and kidney damage. Methods: Adult male Sprague-Dawley rats were divided into control and hypertension groups (8 per group). Angiotensin II vehicle was given to the control group and angiotensin II (0.7 mg/kg/day) to the hypertension group, both via an osmotic mini pump for 7 days. The animals blood pressures were measured by tail cuff plethysmography on days 1, 3, 5, and 7. On day 7, 24-hour urine, blood, and tissues were collected from the rats. Results: In the hypertension group compared with the control group, there was an increase in systolic blood pressure levels after day 1. While claudin-2 immunoreactivity was reduced in the kidneys, renalase immunoreactivity was increased. There was a decrease in creatinine clearance and an increase in fractional potassium excretion (P < .05). Conclusion: Our results showed that claudin-2 and renalase are associated with renal glomerular and tubular dysfunction and may play discrete roles in the pathogenesis of hypertension. We believe that these potential roles warrant further investigation.Öğe The Role of Adropine and Irisin in an Experimental Hypertension Model(Karger, 2021) Firat, Nihayet; Aydin, Muhammed Ali; Tot, Nilay; Simsek, Sevval; Tastekin, Seyma; Aydogdu, Nurettin[Abstract Not Available]Öğe The Role of Hsp90-eNOS Activation and the Antioxidant Mechanism in the Effect of Agomelatine on Arterial Blood Pressure in an Experimental Hypertension Model(Wiley, 2023) Aydin, Muhammed Ali; Firat, Nihayet; Oner, Ozan; Aydogdu, Nurettin; Vardar, Selma Arzu[Abstract Not Available]Öğe Voluntary Physical Activity Increases AKT and supresess ERK Activation in the left Ventricle of Female Rats in the High Fructose Feeding-Induced Metabolic Syndrome(Wiley, 2023) Firat, Nihayet; Aydin, Muhammed Ali; Tastekin, Ebru; Aydogdu, Nurettin; Sut, Nejdet; Vardar, Selma Arzu[Abstract Not Available]
