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    Association Between Helicobacter pylori and Pharyngolaryngeal Carcinomas: Role in Development and Prognostic Significance
    (Galenos Yayincilik, 2019) Bayindir, Tuba; Bayindir, Yasar; Firat Koca, Cigdem; Demir, Ismail; Otlu, Baris
    Helicobacter pylori is a worldwide common bacteria that infects humans. This Gram-negative microorganism is microaerophilic, spiral or curved shaped, and urease, catalase and oxidase-positive. It has the ability to live in the acidic environment of the gastric mucosa. It has been shown that H. pylori plays a role in the development of gastric ulcers and malignant lesions. Furthermore, it was reported that H. pylori may be a cause of several systemic illnesses such as cardiovascular, dermatologic, immunologic, neurologic, hematologic, ophthalmologic, gynecologic, endocrine, and hepatobiliary diseases. In addition, positive or negative correlations between H. pylori infection and rhinitis, sinusitis, adenoiditis or adenoid hyperplasia, otitis media, tonsillitis, or tonsil hypertrophy have been demonstrated in various studies in the literature. However, H. pylori's role in the pathogenesis or association with these diseases remains controversial. Some studies reported that systemic immune and inflammatory responses against H. pylori might cause some systemic diseases as well as different types of malignancies. Although there are studies about the role of H. pylori in benign and malignant diseases of the upper and lower respiratory tract, further studies are needed to reveal the pathophysiological relationship between H. pylori infection and respiratory diseases. The aim of this review was to summarize the studies that reported either a positive or negative relationship between H. pylori and benign and malignant diseases of the respiratory tract.
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    Comparison of endoscopic and microscopic methods in stapedotomy: a retrospective analysis
    (Springer, 2023) Celik, Turgut; Erdur, Omer; Gul, Osman; Firat Koca, Cigdem; Colpan, Bahar
    Purpose The goal of the present study was to compare the audiologic results, complications, and advantages/disadvantages of endoscopic and microscopic stapedotomy. Methods Patients who experienced stapedotomy surgery in the Ear Nose Throat Clinic (ENT) of XXXX University Faculty of Medicine between September 2011 and January 2018 were included in the study. The data of all patients were analyzed and divided into two groups. Those who underwent endoscopic stapedotomy were included in group I, and patients who underwent microscopic stapedotomy formed group II. Surgical findings, complications, and operation times were compared for the two groups. Air and bone conduction thresholds were evaluated at the frequencies of 500, 1000, 2000, and 4000 Hz pre- and postoperatively at 1, 3, and 6 months, and the mean (+/- SD) air-bone gap value was recorded. Results While the mean pre- and postoperative air-bone gaps were 34.38 +/- 7.47 dB (23-53 dB) and 9.69 +/- 4.43 dB (0-19 dB), respectively, in group I, 34.32 +/- 7.57 dB (23-6 dB) and 9.62 +/- 4.25 dB (2-23 dB) were the respective means calculated in group II (p < 0.05). When the mean postoperative air-bone gap was compared, there was no statistically significant difference between the two groups (p = 0.774). The mean operative times for groups I and II were 57.22 +/- 4.37 min and 63.70 +/- 7.34 min, respectively (p < 0.001). The requirement for chorda tympani nerve manipulation and scutum curettage was significantly less in group I compared to group II (p = 0.003). Postoperative dysgeusia and postoperative pain were found to be higher in group II than group I, but they were not statistically significant (p > 0.05). Conclusion Endoscopic stapedotomy displayed similar audiological results, shorter operation times, and similar complication rates, as well as being a less invasive surgery, compared to the microscopic approach.
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    Review of pathophysiology, epidemiology, diagnosis and treatment methods in motion sickness; A special issue
    (2017) Firat Koca, Cigdem; Bayindir, Tuba
    Motion sickness (MS) is a syndrome characterized with nausea and vomiting, pallor, cold sweating, headache, dizziness, increased salivation, apathy, hyperventilation, and stomach awareness. Nausea is one of the most prominent symptoms of MS and very little known about the neural substrate of this sensation. There is no abrupt accepted explanation about why people get motion sickness. It has long been suspected that genetic and /or evoluntary factors govern motion sickness susceptibility. The prevalence is higher among the female gender. The main causes in adulthood are still unknown, but it has been suggested that this condition can be related to the hormonal cycle. Patients with migraine and Meniere’s disease are prone to experience MS especially in female patients. MS is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Questionnaires, hearth rate variability and electrogastrogram are useful for diagnosis and evaluating MS. Habitual training and drugs are the treatment modalities. The drugs can be divided into the categories: antimuscarinics, H1 antihistamines, and sempathomimetics. The aim of this review is to remind the current knowledge about pathogenesis, epidemiology, diagnosis and treatment methods of the special issue: motion sickness.