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Öğe Body odor in dermatologic diagnosis(Excerpta Medica Inc, 1999) Senol, M; Fireman, PPatients with an unpleasant body odor often consult dermatologists. A dermatologist needs to become familiar with the occurrence and significance of medically related odors. Although body odor may be essentially physiological, and problems with body malodor are paid little attention, they can cause many personal troubles and may induce a variety of psychosocial disturbances. Body odor in general is an indicator of individual care and hygiene, or results from eating garlic, onion, spicy foods, curry, or drinking alcohol; however, in some instances it can be pathologic. It is a well-known clinical fact that many diseases (both of internal and cutaneous origin), several syndromes, and some intoxications cause characteristic, peculiar, and identifiable odors. Their identification can provide diagnostic clues, guide the laboratory evaluation, and help in the choice of immediate and appropriate therapy. Thus, olfactory evaluation can be an important part of clinical examination and olfactory diagnosis is still valid in recognizing certain diseases. This report reviews the physiological and pathologic body odors and the importance of olfactory diagnosis in dermatology.Öğe Human cutaneous mast cells: Current concepts(Mary Ann Liebert, Inc, 1997) Senol, M; Fireman, PSkin mast cells play an important role in cutaneous inflammation, especially immunoglobulin-E (IgE)-mediated early type, complement-mediated, and T cell-mediated delayed type hypersensitivity reactions. They can synthesize and release various preformed and newly formed mediators that are important in the pathobiology of certain diseases such as urticaria, mastocytosis, atopic dermatitis, contact dermatitis, bullous pemphigoid, scleroderma, psoriasis, and parasitic skin infections. They also have important functions in parasite infestations, angiogenesis, and tissue remodeling besides allergy and inflammation. Their origin, morphology, distribution, heterogeneity, function, activation, and mediators are included in the subject. Interactions of mast cells with their microenvironment and the other cells, and their role in some pathobiological situations are briefly outlined. This article will reinforce the reader's knowledge of the recent concepts on human cutaneous mast cells.