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    Effects of CO2 insufflation on bacterial growth in rats with Escherichia coli-induced experimental peritonitis
    (Lippincott-Raven Publ, 1997) Sare, M; Yesilada, O; Gurel, M; Balkaya, M; Yologlu, S; Fiskin, K
    The effects of i.p. CO2 insufflation on bacterial proliferation in a setting of Escherichia coli-induced experimental peritonitis was studied in a rat model. Six male Wistar rats were given 0.25 ml of i.p. saline and formed the sham operation group. Twenty-four rats were divided into three groups, and all had i.p. E, coli injections. Microorganism counts were taken after 8 h in ail groups. Group I was used as the control group. Group 2 (laparoscopy) was insufflated with CO2, and group 3 (laparotomy) had a midline laparotomy. Microorganism counts were repeated 8 h after the procedures (16 h after i.p. E. coli inoculation). Postoperative microorganism counts were significantly higher in the CO2 insufflation group (p < 0.05) compared with the control and laparotomy groups and showed an increase, whereas they decreased in the other two groups.
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    Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage
    (Wiley, 2004) Ates, B; Yilmaz, I; Geckil, H; Iraz, M; Birincioglu, M; Fiskin, K
    Tissue injury resulting from ischemia-reperfusion is of fundamental importance. Experimental evidence suggests that the generation of reactive oxygen species is significantly responsible for this type of injury. In the present study, besides investigating the protective role of melatonin on tissue damage caused by intestinal ischemia-reperfusion, the protective activity of this compound was also analyzed in both pre- and post ischemia melatonin-treated rats. The activities of the main antioxidative enzymes, catalase, superoxide dismutase and glutathione peroxidase in the intestine showed significant (P < 0.05) increases in melatonin-treated animals that were subjected to ischemia/reperfusion compared with those subjected only to ischemia/reperfusion. Also, results clearly indicate that the level of malondialdeyhde, an index of lipid peroxidation, decreased significantly (P < 0.05) when rats subjected to intestinal/reperfusion were given melatonin either before ischemia or before reperfusion.