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    EFFECT OF SUBACROMIAL HYALURONIC ACID INJECTION ON THE NORMAL ROTATOR CUFF TENDON: AN EXPERIMENTAL STUDY IN RAT
    (2022) Duman, İbrahim Gökhan; Dogramacı, Yunus; Gökce, Hasan; Bayraktar, Hamdullah Suphi
    ntroduction: Clinically hyaluronic acid injection has been used in treating shoulder pain and was found to be effective for patients with rotator cuff tears. The aim of the present experimental study was to evaluate cellular changes in the rotattor cuff after hyaluronic acid injection into subacromial area, compared to subacromial injections with normal saline. Material and Method: Ten male Wistar rats were used in the study. Both the right (study n=10) and left (control n =10) shoulders were used for subacromial injection in each rat. The hyaluronic acid doses were given 0.1ml of hyaluronic acid (HYALGAN®*) were injected subacromially into the right shoulder (s tudy group) and 0.1ml of saline solution were given into the subacromial space of the left shoulder (control group) once weekly for consecutive 3 weeks. One week after the last injection, the rats were sacrificed with a lethal dose of Xylazine HCl and Ketamine HCl. Next, the right and left shoulder joints including the supraspinatus and infraspinatus tendons were carefully dissected and slices were subjected to routine hematoxylin and eosin (H&E) staining procedure, and then were examined under a light microscope. Differences between groups, regarding animals’ weight, were evaluated using Student’s t-test for independent variables. The level of statistical significance was set at p<0.05. Results: Macroscopically: norma l tendon structures were observed in both groups. Microscopically: no statistically significant pathologic changes including necrosis, inflammation and giant cell infiltration were observed on microscopic examination of both the control and study shoulders (p= .5921). Conclusion: Hyaluronic acid injection into the subacromial area has no adverse histopathologic effects on the healthy rottator cuff.