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Öğe Association between latent toxoplasmosis and clinical course of schizophrenia-continuous course of the disease is characteristic for Toxoplasma gondii-infected patients(Czech Academy of Sciences, 2015) Çelik T.; Kartalci S.; Aytaş O.; Akarsu G.A.; Gözükara H.; Ünal S.The aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15× higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients. © Institute of Parasitology, Biology Centre CAS.Öğe The effect of the intercondylar notch width index on anterior cruciate ligament injuries: A study on groups with unilateral and bilateral ACL injury(ARSMB-KVBMG, 2015) Görmeli C.A.; Özdemir Z.; Kahraman A.S.; Yildirim O.; Görmeli G.; Öztürk B.Y.; Gözükara H.Background: To evaluate the relationship of the intercondylar notch width with unilateral and bilateral ACL injury by using MR images. Materials and Methods: The intercondylar notch width index was measured on the MR images of 18 patients with a bilateral ACL injury, 38 patients with a unilateral ACL injury and 53 healthy subjects with a normal ACL and the results of all groups were compared with each other. Results: The mean NWI values were 0,227 (± 0.008) in bilateral injured; 0,245 (± 0.009) in unilateral injured and 0,272 (± 0.01) in control groups and 0,251(± 0.01) in unaffected side of the unilateral group. There were statistically significant differences in intercondylar notch width index (NWI) values between all groups and there was a significant difference between the affected and the unaffected sides in group with unilateral ACL injury. A cutoff value of 0.25 for NWI gave an odds ratio of 26.5 for bilateral and 3.23 for unilateral ACL injuries. Conclusions: The finding that NWI is significantly narrowed in patients with bilateral and unilateral ACL tears compared with the healthy controls suggest a relationship between a narrow NWI and an increased risk of ACL injury. The patients with a narrow NWI should also be screened contralaterally for assessment of ACL injury risk on the other knee. So, specialized training programmes for the people with narrow NWI can be prepared for preventing ACL injuries. © 2015, Acta Orthopædica Belgica.Öğe Transtibial aperfix system in reconstruction of ACL injuries: Radiological and clinical two year follow-up results(SAGE Publications Ltd, 2014) Görmeli G.; Görmeli C.A.; Karakaplan M.; Korkmaz M.F.; Diliçıkık U.; Gözükara H.Objectives: The aim of this this study was to assess the clinical outcomes and fixation durability of the AperFix (Cayenne Madical, Scottsdale, Arizona) system and to determine the effect of patient’s age in arthroscopic reconstruction of the anterior cruciate ligament. Methods: Patients with symphtomatic anterior cruciat ligament rupture underwent arthroscopic reconstruction. Patients were evaluated in terms of range of motion values; Lysholm, Cincinati and Tegner activity scales; laxity testing and complications. Tunnel widening was assessed by AP and lateral radiographs. Early postoperative and last follow-up radiographs were compared. Results: Fifty-one patients were evaluated at a 29 months (range: 25-34 months) follow-up. Mean age at the surgery was 26.5 ± 7.2 years. Lysholm, Cincinati and Tegner activity scales were significantly higher from preop scores. (Lysholm scores: preop: 51.4 ± 17.2 postop: 88.6 ± 7.7 (p<0.001); Tegner activity scores: preop 3.3 ± 1.38 postop: 5,3 ± 1,6 (p<0,001); Cincinati scores: preop: 44.3±17 postop:81,3 ± 13.9 (p<0.001)). There was no significant difference for knee score, range of motion deficits and femoral tunnel enlargement of the patients with below and above 30 years. Conclusion: According to our results with <30 years and above >30 years patient comparison we think that patient’s age is less important than activity level for the surgical treatment decision. The AperFix system performed satisfactory clinical and radiological results with low complication rate. But long-term clinical and radiological results are needed to decide the ideal ACL reconcstruction method. © The Author(s) 2014.